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Marker for determining diabetic nephropathy

A diabetic nephropathy and biomarker technology, applied in biological testing, disease diagnosis, biomaterial analysis, etc., can solve the problems of inability to determine the risk of diabetic nephropathy, unclear practical application, insufficient differentiation, etc., to prevent kidney disease. Effects of functional insufficiency, reduced medical expenses, and improved quality of life

Active Publication Date: 2018-07-17
TOHOKU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these diagnoses are considered to be problematic in that they are insufficient to differentiate from renal diseases other than diabetic nephropathy
However, although the concentrations of the identified biomarkers (compounds) show statistically significant differences between different disease stages, the differences are small, and it is not clear whether they can be put to practical use
In addition, the above biomarkers cannot determine the risk of diabetic nephropathy

Method used

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  • Marker for determining diabetic nephropathy
  • Marker for determining diabetic nephropathy
  • Marker for determining diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Plasma samples and urine samples were collected from 316 subjects (143 males and 173 females), and gender, 11 items (phenylsulfate [PS] concentration, heart rate, plasma glucose concentration, hemoglobin A1c [HbA1c] value) , urine pH value, estimated glomerular filtration rate [eGFR], urinary albumin / creatinine ratio [ACR], triglyceride [TG] value, uric acid [UA] value, blood urea nitrogen [BUN] value, Pulse wave velocity [PWV] value) to check. Multivariate regression analysis was performed with PS concentration as the membership function, and the inspection values ​​of the above 10 items except PS concentration plus 12 values ​​of age and sex as independent variables. As a result, PS concentration was compared with plasma glucose concentration (p=0.343) and HbA1c value (p=0.351) as indicators of diabetes, eGFR (p=0.512) and BUN value (p=0.046) as indicators of renal function, as The TG value (p=0.368) of the liver function index, the UA value (p=0.524) as the gout ind...

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Abstract

The present invention addresses the problem of providing a biomarker that enables determination of the risk of developing diabetic nephropathy (in particular, diabetic nephropathy in the early stages)or the stage of the disease. Phenylsulfuric acid or a salt thereof (phenylsulfuric acids) are detected through measurement or quantification of the concentration of the phenylsulfuric acids in a biological sample, preferably blood plasma or urine, collected from a subject, and diabetic nephropathy is determined therefrom. The present invention exhibits a particularly superior effect in the determination of the first stage (incipient nephropathy) to the third stage (overt nephropathy) of the disease and in the determination of the risk of developing diabetic nephropathy (early diabetic nephropathy).

Description

technical field [0001] The present invention relates to a method for determining diabetic nephropathy, and a biomarker for determining diabetic nephropathy used in the method for determining diabetic nephropathy. Background technique [0002] Diabetes is known to induce various chronic vascular complications, and its prognosis is influenced by its comorbidities. Among them, diabetic nephropathy is important for the prognosis of life, so it is hoped that its onset and risk of onset can be diagnosed at an early stage so as to prevent the progression of the disease. [0003] Conventionally, the stage diagnosis of diabetic nephropathy was based on changes in urine observation results (detection of proteinuria and microalbuminuria), estimated glomerular filtration rate (eGFR) in addition to the past history of diabetes. Diagnosis is based on the reduction of blood pressure and fundus examination results (observation of fundus vascular lesions). However, these diagnoses are cons...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/49G01N27/62G01N33/53
CPCG01N33/53G01N33/5308G01N33/6893G01N33/84G01N2800/347G01N2800/56G01N33/49G01N33/6851G01N2333/435
Inventor 阿部高明小川晋富冈佳久
Owner TOHOKU UNIV
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