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Potassium aspartate compound electrolyte injection and preparation method thereof

A technology of potassium aspartate and compound electrolyte, which is applied in the field of potassium aspartate compound electrolyte injection and preparation thereof

Inactive Publication Date: 2018-07-13
LIAONING YAOLIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problems described above

Method used

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  • Potassium aspartate compound electrolyte injection and preparation method thereof
  • Potassium aspartate compound electrolyte injection and preparation method thereof
  • Potassium aspartate compound electrolyte injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Composition of prescription:

[0047]

[0048] Preparation:

[0049] (1) Concentration: Place sodium chloride, potassium aspartate, magnesium chloride, sodium acetate, calcium gluconate, sodium citrate and xylitol in a concentration tank according to a predetermined ratio, and add according to the total amount of water for injection 60% water for injection, adjust pH to 7.2, circulate for 20 minutes;

[0050] (2) Pyrogen removal: add activated carbon for injection at 0.5% g / ml, circulate for 20 minutes, filter with 0.45um pore size filter to remove carbon;

[0051] (3) Dilute preparation: pump the concentrated solution into the solution tank, add water for injection to full volume, circulate for 40 minutes, filter with 0.22um pore size filter membrane to obtain filtrate;

[0052] (4) Filling: Filling into a multi-layer co-extrusion infusion bag, each bag is 500ml or 250ml;

[0053] (5) Sterilization: After filling, sterilize at 115°C for 30 minutes to obtain the product.

Embodiment 2

[0055] Composition of prescription:

[0056]

[0057] Preparation:

[0058] (1) Concentration: Place sodium chloride, potassium aspartate, magnesium chloride, sodium acetate, calcium gluconate, sodium citrate and xylitol in a concentration tank according to a predetermined ratio, and add according to the total amount of water for injection 80% water for injection, adjust the pH to 6.7, and circulate for 30 minutes;

[0059] (2) Pyrogen removal: add activated carbon for injection at 0.2% g / ml, circulate for 25 minutes, filter with 0.45um pore size filter to remove carbon;

[0060] (3) Dilute preparation: pump the concentrated solution into the solution tank, add water for injection to full volume, circulate for 30 minutes, filter with 0.22um pore size filter membrane to obtain the filtrate;

[0061] (4) Filling: Filling into a multi-layer co-extrusion infusion bag, each bag is 500ml or 250ml;

[0062] (5) Sterilization: After filling, sterilize at 121°C for 30 minutes to obtain the produ...

Embodiment 3

[0064] Composition of prescription:

[0065]

[0066]

[0067] Preparation:

[0068] (1) Concentration: Place sodium chloride, potassium aspartate, magnesium chloride, sodium acetate, calcium gluconate, sodium citrate and xylitol in a concentration tank according to a predetermined ratio, and add according to the total amount of water for injection 40% water for injection, adjust the pH to 4.3, and circulate for 40 minutes;

[0069] (2) Pyrogen removal: add activated carbon for injection at 0.1% g / ml, circulate for 30 min, filter with 0.45um pore size filter to remove carbon;

[0070] (3) Dilute preparation: pump the concentrated solution into the solution tank, add water for injection to full volume, circulate for 30 minutes, filter with 0.22um pore size filter membrane to obtain the filtrate;

[0071] (4) Filling: Filling into a multi-layer co-extrusion infusion bag, each bag is 500ml or 250ml;

[0072] (5) Sterilization: After filling, sterilize at 121°C for 15 minutes to obtain the ...

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Abstract

The invention provides potassium aspartate compound electrolyte injection and a preparation method thereof. 1000 mL of injection comprises the following components in parts by weight: 3 to 15 g of sodium chloride, 0.1 to 0.2 g of potassium aspartate, 0.05 to 1.0 g of magnesium chloride, 0.2 to 5.0 g of sodium acetate, 0.2 to 3.0 g of calcium gluconate, 0.2 to 3.0 g of sodium citrate, 10 to 200 g of xylitol and the balance of water. The product is total intravenous nutritional injection, can provide various kinds of electrolyte and sugar for an organism simultaneously, and can fulfill the aimsof supplementing body fluid for the organism, maintaining water and electrolyte balance and providing energy. Furthermore, the potassium aspartate compound electrolyte injection does not depend on insulin metabolization, is very suitable for diabetics and hepatopath to use, is stable in metabolization, is particularly suitable for trauma and operation patients to use, promotes wound healing of theoperation and trauma patients and improves the immunologic function.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical preparations, and specifically relates to a potassium aspartate compound electrolyte injection and a preparation method thereof. Background technique [0002] Disorders of water and electrolyte metabolism are very common clinically. Many organ system diseases, some systemic pathological processes, such as liver cirrhosis, diabetes, pulmonary heart disease, burns and scalds, and after surgery, can cause or be accompanied by water and electrolyte metabolism disorders; certain changes in the external environment, certain Iatrogenic factors such as improper use of drugs often lead to disorders of water and electrolyte metabolism. If not corrected in time, the disorder of water and electrolyte metabolism itself will lead to corresponding obstacles in the physiological functions of the body's various organ systems, especially the cardiovascular system and nervous system, and the body's material metabolism, whi...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61P3/12A61P3/02A61K31/198A61K33/06A61K31/19A61K31/191A61K31/194A61K31/047
CPCA61K9/0019A61K9/08A61K31/047A61K31/19A61K31/191A61K31/194A61K31/198A61K33/06A61K33/14A61K2300/00
Inventor 于航陶闰红毕洪书
Owner LIAONING YAOLIAN PHARMA
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