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T-shaped trachea cannula with antibacterial and anti-hyperblastosis functions

A technology of endotracheal intubation and function, which is applied in the direction of endotracheal intubation, catheters, and medical equipment to achieve the effects of improving scar hyperplasia, prolonging the antibacterial effect, and improving the symptoms of scar hyperplasia

Inactive Publication Date: 2018-07-10
SHANGHAI CHANGHAI HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been practiced to improve the bacterial infection and tissue hyperplasia at the interface between the trachea and the intubation

Method used

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  • T-shaped trachea cannula with antibacterial and anti-hyperblastosis functions
  • T-shaped trachea cannula with antibacterial and anti-hyperblastosis functions
  • T-shaped trachea cannula with antibacterial and anti-hyperblastosis functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: 10 g of water-soluble carboxymethyl chitosan (molecular weight 45 KD, carboxyl substitution degree 80%) was dissolved in 50 ml of distilled water until clear. Then 50 μg of N,N-dicyclohexylcarbodiimide was added, and after standing at room temperature for 30 min, 5 ml of hydrazine monohydrate was added and magnetically stirred for 4 hours. The reaction solution was dialyzed overnight through a dialysis bag with a molecular weight of 3000, and freeze-dried to obtain hydrazated carboxymethyl chitosan with a yield of 40-55%.

Embodiment 2

[0032] Example 2: Under nitrogen atmosphere, 1 g of dexamethasone, 4 g of succinic anhydride and a small amount of dimethylaminopyridine were dissolved in 100 ml of acetone, and stirred overnight at room temperature. The solvent was evaporated to obtain white crystals, which were then dissolved in 20 ml of 25 ethanol solution, recrystallized at 4°C, and the product dexamethasone-succinic acid was collected by filtration.

Embodiment 3

[0033] Embodiment three: the hydrazated carboxymethyl chitosan that 1g embodiment one obtains is dissolved in the NaHCO of 50ml in the solution, under room temperature condition, the dexamethasone-succinic acid that 50mg embodiment two obtains is fully dissolved in 20ml two Methyl formamide, and the solution was slowly added dropwise to the above-mentioned hydrazated carboxymethyl chitosan solution, and reacted in the dark for 72 hours. After the reaction was completed, 100ml of tetrahydrofuran was added, and after the precipitate was precipitated, it was collected by filtration, dissolved in deionized water, and after repeated treatment, the product was vacuum-dried for 48 hours to obtain dexamethasone-grafted carboxymethyl chitosan, and the NMR detection substitution yield was 50%.

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Abstract

The invention discloses a T-shaped trachea cannula with antibacterial and anti-hyperblastosis functions. The surface of the T-shaped trachea cannula is covalently coupled with dexamethasone grafted carboxymethyl chitosan and further crosslinked with a hydrophilic coating, wherein the hydrophilic coat can reduce the friction damage of the T-shaped cannula to the laryngeal airway; chitosan plays anantibacterial and healing promoting role; dexamethasone can be slowly released into the airway along with degradation of a joining hydrazone bond, and scar hyperplasia is improved. The T-shaped trachea cannula with the antibacterial and anti-hyperblastosis functions is suitable for being indwelled and used in the body of a patient for a short or long period of time.

Description

technical field [0001] The invention relates to a tracheal T-shaped intubation tube with antibacterial and anti-tissue proliferation functions, in particular to a T-shaped tracheal intubation tube containing dexamethasone and with antibacterial and anti-tissue proliferation functions and a preparation method thereof. Background technique [0002] At present, most of the laryngeal tracheotomy tubes are made of hydrophobic medical materials, which have a large friction force on the tissues when they intervene in the human body, and can easily damage the epithelial tissues such as the laryngeal airway and blood vessel walls, often causing bacterial infection and scar hyperplasia Symptoms can have a significant impact on the treatment and recovery of patients. Using optical or radiation cross-linking agents to modify the surface of the cannula with hydrophilic polymers such as PVA, PVA, and cellulose is an effective solution to reduce airway damage, but bioincompatible toxic sub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M16/04A61L29/16A61L29/08
CPCA61L29/085A61L29/16A61L2300/232A61L2300/404A61L2300/41A61L2300/412A61L2300/43A61L2300/606A61L2420/06A61L2420/08A61M16/0402A61M2205/0205A61M2205/0238A61M2207/00C08L1/284C08L5/08
Inventor 郑宏良陈怀文董银梅陈东辉陈世彩杨冬梅高颖娜朱敏辉贺智明李孟王凤英
Owner SHANGHAI CHANGHAI HOSPITAL
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