Antibacterial nanofiber membrane and preparation method thereof

A nanofiber membrane and fiber membrane technology, applied in fiber treatment, biochemical fiber treatment, textiles and papermaking, etc., can solve the problems of unfavorable production and promotion, difficult cost control, high price, etc., to improve antibacterial effectiveness and broad spectrum , low price, good antibacterial effect

Inactive Publication Date: 2018-07-06
JIAXING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Yet inventor finds, these patents all are nano-silver loaded on the chitosan nano-fiber film, thereby improve the antibacterial property of chitosan nano-fiber film, although the anti-bacterial property of nano-silver has good effect, the price is high, the cost is difficult Controlled, and easy to change color, not conducive to production and promotion

Method used

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  • Antibacterial nanofiber membrane and preparation method thereof
  • Antibacterial nanofiber membrane and preparation method thereof
  • Antibacterial nanofiber membrane and preparation method thereof

Examples

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preparation example Construction

[0022] figure 1 It is a method flowchart of a method for preparing an antibacterial nanofiber membrane shown according to an exemplary embodiment, and the method includes:

[0023] Step 101, dissolving the purified chitosan in a mixed solvent of 3% acetic acid and dimethyl sulfoxide, and dissolving it with a magnetic stirrer at a temperature of 30° C. for 12 hours to obtain a spinning solution with a concentration of 3.0%. , then carry out electrospinning process to described spinning solution, obtain the chitosan nanofiber membrane that average fiber diameter is 188 ± 62nm, the process parameter of described electrospinning process comprises: spinning voltage is 16kV, and receiving distance is 150mm, the spinning rate is 0.6mL / h.

[0024] Step 102, after crosslinking the chitosan nanofiber membrane with glutaraldehyde vapor for 12 hours, put it into a drying room for vacuum drying, and then put it into a petri dish.

[0025] The chitosan nanofiber membrane after crosslinkin...

Embodiment 1

[0039] (1) Dissolve the purified chitosan in a mixed solvent of 3% acetic acid and dimethyl sulfoxide, and dissolve it with a magnetic stirrer at a temperature of 30°C for 12 hours to obtain a spinning solution with a concentration of 3.0%. , then carry out electrospinning process to described spinning solution, obtain the chitosan nanofiber membrane that average fiber diameter is 188 ± 62nm, the process parameter of described electrospinning process comprises: spinning voltage is 16kV, and receiving distance is 150mm, the spinning rate is 0.6mL / h.

[0040] (2) After cross-linking the chitosan nanofiber membrane with glutaraldehyde vapor for 12 hours, put it into a drying room for vacuum drying, and then put it into a petri dish.

[0041](3) The copper sulfate solution of 5mL0.02mol / L, the sodium hydroxide solution of 2.5mL0.2mol / L, the vitamin C solution of 5mL0.04mol / L are sequentially added to the place where the chitosan nanofiber membrane is placed. In the above petri di...

Embodiment 2

[0044] (1) Dissolve the purified chitosan in a mixed solvent of 3% acetic acid and dimethyl sulfoxide, and dissolve it with a magnetic stirrer at a temperature of 30°C for 12 hours to obtain a spinning solution with a concentration of 3.0%. , then carry out electrospinning process to described spinning solution, obtain the chitosan nanofiber membrane that average fiber diameter is 188 ± 62nm, the process parameter of described electrospinning process comprises: spinning voltage is 16kV, and receiving distance is 150mm, the spinning rate is 0.6mL / h.

[0045] (2) After cross-linking the chitosan nanofiber membrane with glutaraldehyde vapor for 12 hours, put it into a drying room for vacuum drying, and then put it into a petri dish.

[0046] (3) The copper sulfate solution of 5mL0.02mol / L, the sodium hydroxide solution of 2.5mL0.2mol / L, the vitamin C solution of 5mL0.04mol / L are sequentially added to the place where the chitosan nanofiber membrane is placed. In the petri dish, a...

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Abstract

The invention discloses an antibacterial nanofiber membrane and a preparation method thereof and belongs to the technical field of nano materials. According to the antibacterial nanofiber membrane andthe preparation method thereof, a chitosan nanofiber membrane is prepared through electrostatic spinning, and with vitamin C which is beneficial to human body as reducing agent, nano cuprous oxide antibacterial agent is prepared through in-situ synthesis on the chitosan nanofiber membrane so that the chitosan nanofiber membrane can contain nano cuprous oxide to improve antibacterial effectivenessand broad spectrum properties; applied chitosan is rich in resource, copper sulfate, sodium hydroxide and vitamin C are all commonly used materials and accordingly are low in price, and preparation processes are free from high-temperature treatment, simple and convenient and achieves the technical effects of low cost, high efficiency, no pollution and low energy consumption; the obtained antibacterial nanofiber membrane has a bionic natural extracellular matrix structure, and the nano cuprous oxide can be uniformly dispersed in the chitosan nanofiber membrane to achieve high antibacterial performance.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to an antibacterial nanofiber membrane and a preparation method thereof. Background technique [0002] Chitosan is the second largest polysaccharide after cellulose on the earth, and it is also the only basic amino acid polysaccharide found in nature. Chitosan has good biocompatibility, biodegradability, and antibacterial properties, so it is Widely used in biomedical fields such as medical dressings, hemostatic supplies, anti-adhesion films, and tissue engineering scaffold materials. [0003] When chitosan is used in medical dressings, the prepared chitosan nanofibers have a large specific surface area and high porosity, so they have good oxygen and gas permeability, which is beneficial to wound tissue cell respiration, epithelial tissue growth and regeneration, can significantly speed up wound healing. Although chitosan has certain antibacterial properties and only has a h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/42D04H1/728D06M11/13D06M11/57D06M13/00D06M16/00
CPCD04H1/42D04H1/728D06M11/42D06M13/123D06M16/00
Inventor 张葵花颜志勇
Owner JIAXING UNIV
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