Processing method of polygene combined excrement DNA (deoxyribonucleic acid) methylation detection data

Abstract

The invention provides a processing method of polygene combined excrement DNA (deoxyribonucleic acid) methylation detection data. The method comprises the following steps of obtaining gene data to bedetected; obtaining gene sample data to be detected from the gene data to be detected; performing various kinds of three gene combined detection on the gene sample data to be detected; respectively obtaining the positive detection rate of each combined detection; inspecting the positive detection rate x2 of each combined detection to obtain a value P, wherein if the value P is greater than the setP value proportion, the current three gene combined detection is the optimum three gene combined detection mode; finally, detecting the gene data to be detected through the optimum three gene combined detection mode so as to obtain the current detection data. The detection result of the combined detection mode is more precise; the positive rate and the specificity are high; the cost is low; the method can be used for screening early-stage CRC (colorectal cancer) clinic sensitivity and specificity.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for processing data of feces DNA methylation combined with multiple genes. Background technique [0002] Colorectal cancer (CRC) is the most common malignant tumor of the digestive tract. In recent years, with the continuous improvement of living standards, the incidence of CRC has been increasing year by year, but most cases are diagnosed in the middle and late stages, and the prognosis is poor. Good, high mortality rate. Its early symptoms are not typical, and early detection can significantly improve the prognosis, increase the survival time of patients, and reduce the mortality rate. At present, the commonly used clinical screening methods for colorectal cancer mainly include electronic colonoscopy detection and fecal occult blood test (FOBT). Wide application in CRC screening. [0003] In recent years, DNA methylation has been recognized as an important factor i...

AI Technical Summary

Problems solved by technology

However, the detection rate and specificity of single-gene fecal DNA methylation detection in diagnosing CRC are low. Although multi-gene methylation detection can improve the detection rate, with the increase in the number of genes for joint detection, the cost will also increase. High-cost detection methods are obviously not suitable for large-scale early screening of CRC. Therefore, looking for an optimal gene combination that has a high positive detection rate and specificity and can reduce detection costs is essential for CRC screening. Significant

Images