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Application of combined marker in preparation of pancreatic cancer prognosis kit as well as determining system and method of combined marker

A pancreatic cancer, marker technology, applied in the field of combined markers

Active Publication Date: 2018-06-01
KANTE SHENZHEN BIOTECHNOLOGIES INC
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Problems solved by technology

At present, although some common clinicopathological indexes, such as lymph node metastasis, neural invasion, TNM staging, and CA19-9, are considered to have certain prognostic value[1], there is still an urgent need to discover more effective prognostic indicators to guide the diagnosis of pancreatic cancer. Clinical diagnosis and treatment

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  • Application of combined marker in preparation of pancreatic cancer prognosis kit as well as determining system and method of combined marker
  • Application of combined marker in preparation of pancreatic cancer prognosis kit as well as determining system and method of combined marker
  • Application of combined marker in preparation of pancreatic cancer prognosis kit as well as determining system and method of combined marker

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Embodiment

[0098] In order to verify the value of the present invention in predicting the survival of pancreatic cancer patients, the inventors independently analyzed 120 cases of pancreatic cancer patients. Patients ranged in age from 40 to 89 years (median age, 66 years). Follow-up began the day after surgery and ranged from 2 months to 96 months, with a median follow-up period of 11 months.

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Abstract

Pancreatic cancer is tumor with very poor prognosis and recognition of effective prognosis markers of the pancreatic cancer has great significance. The invention provides a method for assessing the prognosis risk of pancreatic cancer patients on the basis of a combined marker and a determining system of the method. The prognosis risk index is quantitatively calculated according to the expression condition of the combined marker in case samples, and layering of high and low risks of cases is performed. The invention relates to the combined marker consists of five proteins (the prognosis significance of CAPN2, DVL1 and FLNA among CAPN2, DVL1, FLNA, SHH and GLI1 for the pancreatic cancer is established for the first time), an immunohistochemical kit for detecting expression of the marker, a prognosis risk assessment and layering determining system and the like. Case implementation results in 280 and 120 cases of pancreatic cancer patients indicate that the combined marker can effectivelypredict prognosis risk of pancreatic cancer patients and has significant prediction effects on pancreatic cancer subgroup patients with high prognosis risk.

Description

technical field [0001] The invention relates to a combined marker, its application in preparing a composition for judging the prognosis of patients with pancreatic cancer, and its measurement system and method. Background technique [0002] Pancreatic cancer is a tumor with a very poor prognosis, and its mortality rate is basically equal to the incidence rate. Identifying factors with prognostic value has important clinical implications. At present, although some common clinicopathological indexes, such as lymph node metastasis, neural invasion, TNM staging, and CA19-9, are considered to have certain prognostic value[1], there is still an urgent need to discover more effective prognostic indicators to guide the diagnosis of pancreatic cancer. clinical diagnosis and treatment. [0003] As a complex disease, pancreatic cancer is not determined by a single gene or its product, but the systemic response of multiple pathological processes in the development of tumors, so the re...

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Application Information

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IPC IPC(8): G01N33/68G01N33/574
CPCG01N33/57438G01N33/57484G01N33/6893G01N2800/52
Inventor 赵玉沛李梢郭俊超张鹏周立
Owner KANTE SHENZHEN BIOTECHNOLOGIES INC
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