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Meperfluthrin and propoxur compound effervescent tablets, and preparation method and application thereof

A technology of chlorofluthrin and effervescent tablet is applied in the field of compound insecticidal compositions, which can solve the problems of non-compliance with production, transportation, storage process, inability to achieve accurate quantification, non-compliance with environmental protection policies, etc. Good lethal effect, accurate dose, and the effect of enhancing the killing control ability of individual soldiers

Inactive Publication Date: 2018-05-22
JIANGSU YANGNONG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned dosage forms do not meet the requirements of production, transportation, and storage processes. In addition, it is difficult to measure when used for preparation and dilution, and cannot achieve accurate quantification. It does not comply with a series of relevant national environmental protection policies.

Method used

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  • Meperfluthrin and propoxur compound effervescent tablets, and preparation method and application thereof
  • Meperfluthrin and propoxur compound effervescent tablets, and preparation method and application thereof
  • Meperfluthrin and propoxur compound effervescent tablets, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the effervescent tablet containing nano clathrate carrier

[0036] The compounding ratio of component A dichlorothrin and component B propoxur is listed as 1:5, and the actual feeding materials are 1g of bifluethrin, 5g of propoxur, 6g of naphthalenesulfonic acid formaldehyde condensate, 4g of dodecyl Sodium sulfate, 15g sodium bicarbonate, 5g ammonium sulfate, 5g soluble starch, 1g talc, 12g citric acid, 25g β-cyclodextrin, 21g corn starch.

[0037] The preparation steps are as follows:

[0038] (1) First, component A and component B are solidified with nano-inclusion carrier. The specific steps are: add 25g of β-cyclodextrin to 75g of water, then heat to make a saturated aqueous solution, and slowly add 10g of β-cyclodextrin under magnetic stirring conditions. Dissolve 1g of component A and 5g of component B in water and ethanol, continue to stir for 1-5h, refrigerate to precipitate white precipitate, filter, and blow dry at 50°C to 80°C to obtain nano ...

Embodiment 2-7

[0043] Embodiment 2-7: Effervescent tablet containing nano clathrate carrier

[0044] According to the compounding ratio of component A and component B in Table 1, the auxiliary components are: 6g naphthalenesulfonic acid formaldehyde condensate, 4g sodium lauryl sulfate, 12g citric acid, 15g sodium bicarbonate, 1g talcum powder, 25g beta - Cyclodextrin, 5g ammonium sulfate, 5g soluble starch, and corn starch make up 100%. The specific preparation steps are the same as in Example 1, and finally Preparation Examples 2-7 are prepared.

[0045] Table 1: The compounding proportion of embodiment 2-6 component A and component B

[0046]

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Abstract

The invention discloses meperfluthrin and propoxur compound effervescent tablets, and a preparation method and an application thereof. The effervescent tablets are prepared by compounding a raw medicine component and an auxiliary component, wherein the raw medicine component accounts for 10%-22% of the total weight of the effervescent tablets, and the auxiliary component accounts for 78%-90% of the total weight of the effervescent tablets; the raw medicine component is prepared by compounding a component A and a component B according to the weight ratio of 1:(5-50), wherein the component A isa pyrethroid compound represented by the formula A, and the component B is propoxur represented by the formula B; the auxiliary component includes a nano inclusion complex carrier, an acid source, a carbon dioxide source, a binder, a wetting dispersant, a disintegration agent, a lubricant and the like. The insecticidal effervescent tablet has the advantages of insecticidal spectrum expansion, efficiency increasing, easy storage and use and the like.

Description

technical field [0001] The invention relates to a compound insecticide composition, which contains biflufenethrin and propoxur, and is prepared as an insecticide in the form of an effervescent tablet. Background technique [0002] Meperfluthrin, the English name (Meperfluthrin), is a new pyrethroid compound with independent intellectual property rights developed by Jiangsu Yangnong Chemical Co., Ltd. This compound is currently mainly used in household hygiene preparations. Prozacarb is recommended by WHO as a hygienic drug for the prevention and control of important vector organisms. At present, the commonly used public health insecticide formulations for commercial residual spraying include emulsifiable concentrates, suspension concentrates, wettable powders, etc. The above-mentioned dosage forms do not meet the requirements of production, transportation, and storage processes. In addition, it is difficult to measure when used for preparation and dilution, and accurate qua...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/10A01N25/34A01N53/06A01N47/22A01P7/04
CPCA01N25/10A01N25/34A01N47/22A01N53/00A01N2300/00
Inventor 周其奎秦冬冬刘卫荣张瑜蓉潘学峰苏恩鹏
Owner JIANGSU YANGNONG CHEM
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