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Industrial production method of lactulose

A production method, lactulose technology, applied in the field of preparation of functional sugar alcohols, can solve the problems of low yield and purity of lactulose, complex post-treatment process, long preparation process, etc., achieve process optimization, broad industrial application prospects, save The effect of process and time

Pending Publication Date: 2018-05-18
山东绿健生物技术有限公司
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0003] The lactose isomerization method is currently the main method for preparing lactulose, which mainly relies on 1) strong alkaline reagents such as NaOH, KOH, Mg(OH) 2 or organic base triethylamine; or 2) weakly basic reagents such as basic magnesium salts, phosphates or sulfites of alkaline or alkaline earth metals; or 3) adding borate or aluminate as a catalyst under alkaline conditions , isomerize lactulose into lactulose in a high-temperature environment, but the above-mentioned methods generally have disadvantages such as low yield and purity of lactulose, complex post-treatment process, long preparation process, and high energy consumption, which have become restrictions on the expansion of the lactulose industry. bottleneck problem

Method used

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  • Industrial production method of lactulose
  • Industrial production method of lactulose

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Lactose sugar 15 cubic meters, refraction 67%, pH 6, temperature 48°C, flow rate 5.5 cubic meters / hour, feed conductivity 1895 μs / cm, light transmission 38.5%, feed lactose content 99.5%, lactulose 0.

[0052] Yin bed (D301) discharge, refraction 66.1%, flow rate 5.5 m3 / hour, discharge conductance 187μs / cm, discharge light transmission 97.2%, discharge content: lactulose 12.35%, galactose 1.34%, lactose content 85.6% ,

[0053] Yang bed (D001) output, refraction 65.3%, flow rate 5.5 m3 / hour, output conductance 8.4μs / cm, output light transmission 98.9%, output content: lactulose 12.38%, galactose 1.33%, lactose content 85.55 %.

[0054] The refraction of the evaporation output is 75.6%, the temperature is 80°C,

[0055] Cooling crystallization rate: 1°C / hour, centrifugation temperature 40°C;

[0056] Centrifugal speed: 500-1000 r / min, mother liquor refraction 40-55% after centrifugation, content: lactulose: 71.5%, galactose 8.96%, lactose 13.77%;

[0057] Decolorizat...

Embodiment 2

[0062] 20 cubic meters of lactose, refraction 68%, temperature 45°C, pH 5.5, flow rate 5.5 cubic meters / hour, feed conductivity 1898μs / cm, light transmission 38.1%, feed lactose content 99.6%, lactulose 0.

[0063] Yin bed (D301) output, refraction 65.4%, flow rate 5.7 m3 / hour, output conductance 168μs / cm, output light transmission 97.3%, output content: lactulose 12.49%, galactose 1.39%, lactose content 85.31% ,

[0064] Yang bed (D001) output, refraction 65.3%, flow rate 5.7 m3 / hour, output conductance 7.6μs / cm, output light transmission 98.8%, output content: lactulose 12.45%, galactose 1.31%, lactose content 85.62 %.

[0065] The refraction of the evaporation output is 75.9%, and the temperature is 80°C;

[0066] Cooling crystallization rate: 1°C / hour, centrifugation temperature 40°C;

[0067] Centrifugal speed: 500-1000 r / min, mother liquor refraction 40-55% after centrifugation, content: lactulose: 71.7%, galactose 8.81%, lactose 13.33%;

[0068] Decolorization proce...

Embodiment 3

[0074] Lactosylated sugar 15 m³, refraction 68.2%, temperature 47.6°C, pH 6.5, flow rate 5.5 m³ / hour, feed conductivity 1735 μs / cm, light transmission 38.9%, feed lactose content 99.47%, lactulose 0.

[0075] Yin bed (D301) output, refraction 65.89%, flow rate 5.5 m3 / hour, output conductance 168μs / cm, output light transmission 97.45%, output content: lactulose 12.49%, galactose 1.41%, lactose content 85.44% ,

[0076] Yang bed (D001) output, refraction 65.34%, flow rate 5.5 m3 / hour, output conductance 7.6μs / cm, output light transmission 98.88%, output content: lactulose 12.48%, galactose 1.3%, lactose content 85.59 %.

[0077] The refraction of the evaporation output is 75.8%, the temperature is 80°C,

[0078] Cooling crystallization rate: 1°C / hour, centrifuge temperature 41°C

[0079] Centrifugal speed: 500-1000 rev / min, mother liquor refraction 40-55% after centrifugation, content: lactulose: 71.82%, galactose 8.76%, lactose 13.27%

[0080] Decolorization process: the am...

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Abstract

The invention provides an industrial production method of lactulose. The method includes the step of making a lactulose solution sequentially pass through anion-exchange columns and cation exchange columns at first. The method breaks a traditional thinking pattern, in the first step of obtaining lactulose by means of lactulose isomerism, an alkaline function of weak-base anion-exchange resin is utilized to perform isomerism on lactulose, and meanwhile, a purification function of the resin is also utilized to make the color of a prepared lactulose solution turn light yellow from dark yellow, wherein the conductivity is decreased from 2,000 microseconds / cm to 100-200 microseconds / cm, and the light transmission rate is increased from 35-40% to 97%. Therefore, isomerism and decoloring purification are conducted at the same time, the work processes and time are effectively saved, and the production cost is reduced. The method has a wide industrial application prospect.

Description

technical field [0001] The invention belongs to the technical field of preparation of functional sugar alcohols, and in particular relates to an industrial production method of lactulose. Background technique [0002] Lactulose (also known as isomerized lactose, lactulose) is a stereoisomerized lactose, a disaccharide in which galactose and fructose are combined by β-1,4 glycosidic bonds. In 1957, the Austrian scholar Petuely found that by adding lactulose, the intestinal flora of artificially fed infants could be similar to that of breastfed infants, and it was confirmed for the first time that lactulose is a bifidobacteria proliferation factor. In Japan, lactulose is recognized as a "food for specific health use" additive and is widely used. At present, lactulose is widely used in medicine, health care, food additives and animal feed industries all over the world. In the clinical pharmaceutical industry, lactulose is mainly used to treat hepatic encephalopathy, constipat...

Claims

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Application Information

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IPC IPC(8): C07H3/04C07H1/00C07H1/06
CPCC07H3/04C07H1/00C07H1/06
Inventor 信成夫于丽景文利刘峰刘圣宽于艳丽
Owner 山东绿健生物技术有限公司
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