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Application of rhizoma chuanxiong total alkaloid to preparation of medicine for treating headache

A technology of total alkaloids and Ligusticum chuanxiong, which is applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., to achieve good clinical application prospects, cure headaches, and reduce CGRP levels

Inactive Publication Date: 2018-05-15
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no literature report that Chuanxiong alkaloids have the effect of preventing and treating headache

Method used

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  • Application of rhizoma chuanxiong total alkaloid to preparation of medicine for treating headache
  • Application of rhizoma chuanxiong total alkaloid to preparation of medicine for treating headache
  • Application of rhizoma chuanxiong total alkaloid to preparation of medicine for treating headache

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Embodiment 1

[0041] Embodiment 1 The preparation method of Ligusticum chuanxiong total alkaloids of the present invention

[0042] (1) Take the coarse powder of Ligusticum chuanxiong, use 80% ethanol 15 times the weight of Ligusticum chuanxiong, extract twice at 100°C under reflux for 2.5 hours each time, and concentrate the extract to obtain ethanol extract.

[0043] (2) Dissolve the ethanol extract with 1mol / L hydrochloric acid, filter, adjust the pH of the filtrate to 9-10 with concentrated ammonia water, extract with chloroform until colorless, combine the chloroform extracts, concentrate and evaporate to dryness to obtain the total Crude alkaloid A.

[0044] (3) The crude product A is enriched and purified by AB-8 macroporous adsorption resin. The purification process is that the pH of the sample solution is 8.0, the mass concentration of the sample is 4.4799mg / mL, and the sample volume is 8BV. After removing impurities with 13BV deionized water , and then eluted with 14BV of ethanol...

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Abstract

The invention provides application of rhizoma chuanxiong total alkaloid to preparation of a medicine for treating headache. According to the application provided by the invention, the rhizoma chuanxiong total alkaloid can be used for improving the content of 5-HT (5-hydroxytryptamine), 5-HIAA (5-Hydroxyindole Acetic Acid), ET (Endothelin), NA (Neuramidinase) and DA (Dopamine) in blood plasma and brain tissues of patients with the headache and reducing a CGRP (Calcitonin Gene-Related Peptide) level in the blood plasma and the brain tissues; the rhizoma chuanxiong total alkaloid can be used foreffectively treating the headache and has a good clinical application prospect.

Description

technical field [0001] The invention relates to a new application of the total alkaloids of Rhizoma Chuanxiong, in particular, an application in preparing a medicine for treating headache. Background technique [0002] Migraine is the most common primary headache in clinical practice. The main clinical manifestation is paroxysmal moderate to severe, throbbing headache. The headache is mostly hemilateral and usually lasts for 4-72 hours. It may be accompanied by nausea, vomiting, light and sound stimulation. Or daily activities all can increase the weight of headache, quiet environment, rest can alleviate headache. Migraine is a common chronic neurovascular disease. It usually occurs in children and adolescence, and reaches its peak in young and middle-aged adults. It is more common in women, and the ratio of male to female patients is about 1:2-3. The prevalence rate in the population is 5 %-10%, often with a genetic background. [0003] At present, the pathogenesis of mig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61P25/06A61K125/00
CPCA61K36/236A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 熊亮彭成蒲忠慧谢晓芳
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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