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Preparation method and application of skin regeneration aerogel type dressing

A skin repair and aerogel technology, applied in medical science, bandages, etc., can solve the problems of repeated spraying/smearing, unstable effect, cumbersome operation, etc., to help the wound mature, optimize appearance and function, improve The effect of repairing the mass

Active Publication Date: 2018-05-08
湖北皮可力医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current methods of applying fibroblast growth factor are mostly sprays or ointments, which have disadvantages such as easy loss, repeated spraying / smearing, cumbersome operation, and unstable effect.

Method used

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  • Preparation method and application of skin regeneration aerogel type dressing
  • Preparation method and application of skin regeneration aerogel type dressing
  • Preparation method and application of skin regeneration aerogel type dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The preparation method of a 2cm*2cm*2mm "sandwich type" collagen-graphene oxide loaded bFGF multilayer structure airgel dressing comprises the following steps:

[0045] (1) Take 20mg of type I collagen, add it to 1ml of 0.05M acetic acid solution, and ultrasonicate for 30min in a water bath at 35°C until the solution becomes a 2% w / v solution, which is recorded as solution A;

[0046] (2) Take 4 mg of graphene oxide and add it to 0.5 ml of deionized water to obtain a graphene oxide suspension. Place the graphene oxide suspension in an ultrasonic pulverizer and place it in an ice-water bath to vibrate for 1 hour until the graphite oxide is Alkene becomes microparticle sol B;

[0047] (3) Mix liquid A and liquid B at a ratio of 2:1 by volume, and ultrasonicate for 30 minutes in an ice-water bath to obtain a homogeneous colloidal solution of 1% w / v of collagen and 0.2% w / v of graphene oxide. Vacuumize and degas the colloidal solution, and cool it in a refrigerator at 4°C ...

Embodiment 2

[0054] A kind of diameter is 8mm, and the preparation method of the collagen-graphene oxide skin repairing aerogel that height is 2mm comprises the following steps:

[0055] (1) Take 20mg of type VI collagen, add it to 1ml of 0.05M acetic acid solution, and sonicate for 20min in a water bath at 35°C until the solution becomes a 2% w / v solution, which is recorded as solution A;

[0056] (2) Take 16 mg of graphene oxide and add it to 0.5 ml of deionized water to obtain a graphene oxide suspension. Place the graphene oxide suspension in an ultrasonic pulverizer and place it in an ice-water bath to vibrate for 30 minutes until the graphite oxide Alkene becomes microparticle sol B;

[0057] (3) Mix liquids A and B at a volume ratio of 5:1, ultrasonically degas the homogeneous colloidal solution for 30 minutes in an ice-water bath, and place it in a refrigerator at 4°C for 12 hours until it becomes a colloidal mixture C ;

[0058] (4) Pour the colloidal mixture C into a cylindrica...

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Abstract

The invention provides a preparation method and the application of a skin regeneration aerogel type dressing. Based on collagen and oxidized graphene, in virtue of a preparation technology of aerogel,a relatively compact collagen film on the surface of collagen-oxidized graphene aerogel is used, fibroblast growth factors are slowly released through physical encapsulation and an assembling mannerof a sandwich multilayered structure, and the aerogel dressing which is capable of slowly releasing fibroblast growth factors, promoting climbing and adhesion of fibroblast and promoting wound healing, and is uniform in pore distribution, light in texture and high in moisture absorption, moisture preservation, water absorption, gas permeability and porosity is prepared by adopting a freeze dryingmethod.

Description

technical field [0001] The invention provides a medical dressing, specifically a preparation method and application of an airgel dressing for skin repair. Background technique [0002] Skin defects caused by large-scale deep burns and trauma are common and frequently-occurring diseases in clinical practice. At present, the conventional clinical treatment methods are autologous medium-thickness skin, full-thickness skin transplantation, allogeneic acellular dermal matrix combined with autologous epidermal sheet transplantation, and xenogeneic acellular dermal matrix combined with autologous epidermal sheet transplantation. Autologous skin grafting can reconstruct the skin structure of the defect site and restore its appearance and function, but this method lacks sufficient skin sources and increases pain for patients. The method of allogeneic acellular dermal matrix combined with autologous skin transplantation also has the disadvantage of limited source of allogeneic skin d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0033A61L26/0066A61L26/008A61L26/0085A61L2300/414
Inventor 李嘉伦汪振星孙家明钟爱梅曾宇阳刘绍恺侯金飞周楚超方慧敏周牧冉牟珊罗超黎媛陈雳风张馨月
Owner 湖北皮可力医疗科技有限公司
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