Identification method and system for anoxia-reoxygenation injury of myocardial cells

Abstract

The invention belongs to the technical field of medicines and pharmacology and discloses an identification method and system for anoxia-reoxygenation injury of myocardial cells. Telomerase mitochondrion transposition is regulated and controlled, mitochondria damage can be alleviated, and myocardial energy supply can be improved, so that a myocardial cell protective effect is achieved. The identification method and system which are disclosed by the invention have the advantages that activity and distribution of telomerases are regulated through overexpression of Shp-2ShRNA interference plasmidsand mitochondrion-targeted hTERT at a primary culture neonatal rat myocardial cell level, and the mitochondria damage is analyzed and is also alleviated; and relation between the telomerase mitochondrion transposition and mitochondrial functions is clear, a possible mechanism of the telomerase mitochondrion transposition for alleviating the anoxia-reoxygenation injury of the myocardial cells is analyzed, and a basis is provided for a myocardial protection treatment strategy taking telomerase as a target.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method and system for identifying cardiomyocyte hypoxia-reoxygenation injury. Background technique [0002] Cardiovascular disease (CVD) is the primary cause of global health threats, and myocardial ischemia / reperfusion injury (MI / RI) is considered to be one of the main risk factors for CVD patients. The outcomes were all manifested as inflammatory response and cardiomyocyte apoptosis, thereby affecting myocardial function. At present, the number of people who die from acute myocardial infarction and its complications every year in my country has exceeded 1 million, and the incidence rate has been showing an obvious upward trend. Xinjiang is an area inhabited by many ethnic groups, and Uyghurs and Kazakhs account for more than 50% of Xinjiang's total population. Xinjiang is an area with a high incidence of coronary heart disease in my country. The prevalence of c...

AI Technical Summary

Problems solved by technology

[0009] It affects the energy supply of cardiomyocytes, which is also one of the causes of major perioperative complications in patients with cardiovascular disease (CVD), but there is still a lack of effective intervention methods

[0010] And the p

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