Modular biological analysis system based on droplet array chip, and application of modular biological analysis system

Abstract

The invention discloses a modular biological analysis system based on a droplet array chip, and application of the modular biological analysis system. The system comprises at least one functional module, one or more batteries, and an electronic circuit module, wherein each functional module comprises an optical detection module, a chip motion control module, a magnetic field control module and a temperature control module; the optical detection module, the chip motion control module, the magnetic field control module and the temperature control module are separately connected with the batteries and the electronic circuit module; the optical detection module is connected with the chip motion control module; the magnetic field control module and the temperature control module are positionedunder the chip motion control module. The modular biological analysis system based on the droplet array chip is applied to biological detection. The system has the advantages of being convenient to operate, flexible in application, high in information flux and degree of automation, and the like, thus being very suitable for carrying out biological detection of grass-roots clinics, bedside diagnosis, field detection and areas with limited medical resources.

Description

technical field [0001] The invention belongs to the technical field of biological analysis and medical inspection, and in particular relates to a modular biological analysis system based on a droplet array chip and its application. Background technique [0002] Bioanalysis and medical testing usually include multiple types of testing content, such as biochemical testing, nucleic acid testing, immune testing, microbial testing, etc. At present, most of these detection contents use independent analysis systems, and the analysis process involves multi-step operations. Therefore, traditional biological analysis and medical testing not only have high requirements for the site and the quality of operators, but also face the problems of cumbersome operation, long analysis time and high testing cost. [0003] The recently developed microfluidic droplet technology (droplet microfluidics) has the advantages of high analytical throughput and low sample consumption, and is a powerful t...

AI Technical Summary

Problems solved by technology

Although microfluidic droplet analysis technology has made important progress, there are still some aspects to be improved in this technology, such as: (1) The balance between functional integration and test throughput: At present, most fully integrated microfluidic The control device can only analyze one sample at a time, while the high-throughput analysis device cannot integrate the entire process of nucleic acid analysis, so the development of an integrated micro-analysis device with higher throughput will better meet the needs of clinical applications; (2 ) requires a simple and flexible solution for liquid transfer: the quantitative and positioning transfer of reagents and samples is an important challenge for microfluidic chips; (3) Solving the chip-test tube docking problem: How to introduce reagents and samples stored in the test tube into the closed chip is another problem that needs to be solved for microfluidic chips to be used in practical medicine; analysis is often Batch sample operation and chip-test tube docking are necessary for automated liquid transfer operations; (4) Reduce chip processing costs: Since most microfluidic chips require professional micro-processing technology, the manufacturing cost remains high, which seriously affects this technology. Promotion

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