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Method capable of improving water solubility of curcumin and application

A technology for curcumin and water-solubility, applied in the field of improving the water-solubility of curcumin, can solve problems such as no publication of curcumin, and achieve the effects of rapid solubility improvement, improved solubility, and simple operation

Inactive Publication Date: 2018-04-24
HENAN UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there are no published cases of using plant glycogen as a carrier to load curcumin

Method used

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  • Method capable of improving water solubility of curcumin and application
  • Method capable of improving water solubility of curcumin and application
  • Method capable of improving water solubility of curcumin and application

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Embodiment Construction

[0025] The present invention will be described in detail below in conjunction with specific embodiments. This embodiment provides detailed implementation methods and specific operation processes on the premise of the technical solution of the present invention.

[0026] A method for improving the water solubility of curcumin, said method is to utilize phytoglycogen nanoparticles as a carrier to load curcumin, improve the solubility of curcumin in water, comprising the steps of:

[0027] Step 1. Dissolve phytoglycogen in deionized water to prepare a phytoglycogen aqueous solution with a concentration of 5-20 mg / mL; dissolve curcumin in absolute ethanol to prepare a curcumin with a concentration of 1-4 mg / mL weak;

[0028] Step 2: Add the curcumin ethanol solution prepared in step 1 to the phytoglycogen aqueous solution prepared in step 1, shake and balance in a shaker, centrifuge, discard the insoluble curcumin precipitate, and obtain the supernatant, which is Phytoglycogen-cu...

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Abstract

The invention discloses a method capable of improving water solubility of curcumin and application. The method includes: dissolving curcumin in anhydrous alcohol, adding into plant glycogen water solution dissolved in deionized water, oscillating for balance before centrifuging, collecting supernate, and utilizing plant glycogen nanoparticles as a carrier to load curcumin so as to improve solubility of curcumin in water. The method is simple to operate, mild in condition and high in solubility improving speed; by applying the method, apparent solubility of curcumin can be improved by about 3100 times; the method can be applied in the field of food healthcare products, water-soluble food, dietary nutrient supplements or medicine.

Description

technical field [0001] The invention relates to the fields of functional food and dietary nutritional supplements, in particular to a method and application for improving the water solubility of curcumin. Background technique [0002] Curcumin (CCM), a natural phenolic substance, is composed of β-diketone heptadiene and two adjacent methylated phenols, and has a symmetrical molecular structure. Curcumin is mainly extracted from curcuma longa plants such as turmeric, zedoary, and turmeric. [0003] Curcumin is a multi-effect natural active substance with various pharmacological effects and wide application value. For example, curcumin has anti-tumor, anti-oxidation, anti-inflammatory, anti-human immunodeficiency virus, anti-fibrosis, anti-cancer and anti-cancer, lipid-lowering and liver and kidney protection effects. In addition, curcumin can also be used as a preservative, Cosmetics, stomachic agents, analgesics, diuretics, choleretics, various pharmacological effects such...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/10A61K9/14A61K31/12A61P35/00A61P39/06A61P29/00A61P31/18A61P43/00A61P3/06A61P1/16A61P13/12A61P1/00A61P7/10A61P37/04A61P17/16A61P3/10A61P33/10A23L33/105
CPCA23L33/105A23V2002/00A61K9/145A61K9/146A61K31/12A23V2250/2112
Inventor 樊金玲王攀朱文学韩兴曼杨亚培张月
Owner HENAN UNIV OF SCI & TECH
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