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Application of burdock extract in preparing medicine for protecting elastic fibers and collagen

An elastic fiber and collagen technology, which can be used in drug combinations, plant raw materials, cosmetic preparations, etc., can solve the problems of inability to provide treatment options and high physiological burden of patients, and achieve the effect of avoiding burden and inhibiting inflammation.

Inactive Publication Date: 2018-04-24
贝安股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a burdock extract for the preparation of drugs for protecting elastic fibers and collagen, so as to solve the problem that existing tendonitis treatment methods have a high physiological burden on patients and cannot provide natural and effective treatment options

Method used

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  • Application of burdock extract in preparing medicine for protecting elastic fibers and collagen
  • Application of burdock extract in preparing medicine for protecting elastic fibers and collagen
  • Application of burdock extract in preparing medicine for protecting elastic fibers and collagen

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0038] Please refer to image 3 Shown is a comparison chart of the concentration of burdock extract and cell survival rate (the cell survival rate chart is expressed as survival cells%). The experiment of the present invention uses human tenocytes (Tenocytes), seeded in a culture dish at a concentration of 400,000 cells / slot, and cultured for 1 day until full. After confirming fullness, replace the medium with SFmedium, and process 20 mU of elastase on each culture plate. After the elastase treatment, the solution in which the burdock extract was dissolved was added to each culture plate, the intracellular protein was taken out 24 hours after the treatment, the supernatant was centrifuged, and the supernatant was recovered again to prepare a sample, and The cell survival rate was evaluated by dimethylthiazole cell survival rate analysis (MTT assay). The leftmost side of the horizontal axis in the figure is the control group, which uses the supernatant of the culture plate with...

experiment example 2

[0042] The present invention further studies the effect of the burdock extract on elastic fibers, please refer to Figure 5-1 and Figure 5-2 As shown, the Western blot test was performed on each culture plate to determine the expression level of elastin, and actin (β-Actin) was used as an internal reference. In this experimental example, human tendon cells were also used for culture, the control group was the supernatant after cell culture, and the other culture plates were treated with different concentrations of the burdock extract. by Figure 5-1 It can be seen that the higher the concentration of the burdock extract, the higher the expression level of elastin. Comprehensive experiment example 1 image 3 As a result, it can be seen that the burdock extract not only does not harm tendon cells, but also has the effect of improving the growth efficiency of elastin, and helps tendon cells to form elastic fibers.

experiment example 3

[0044] Following the previous experimental example 2, the present invention further investigates whether the burdock extract can still have a beneficial effect on elastic fibers after adding elastase to tendon cells. Please refer to Figure 6-1 and Figure 6-2 As shown, the expression level of elastin in tendon cells was tested by the Western blot method, supplemented with actin (β-Actin) as an internal reference. In this experimental example, human tendon cells were also used for culturing. Figure 6-1 Among them, the control group is the supernatant after cell culture, and the other culture plates are put into the elastase with a concentration of 20mU, and then the burdock extract with different concentrations is 0, 1, 3, 7 and 15 To process. by Figure 6-1 It can be seen that the higher the concentration of the burdock extract, the higher the expression level of elastin. Based on the results of Experimental Example 2, it can be seen that the burdock extract can increase the ...

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Abstract

The invention discloses an application of a burdock extract in preparing a medicine for protecting elastic fibers and collagen. According to an implementation mode, the peeled burdock extract is applied to an individual having inflammatory symptoms by an effective dose, and an inflammation inhibitory effect is generated on the individual by virtue of the burdock extract, so that elastic fibers andcollagen of the individual are protected from getting injured. Existing inflammation diminishing methods are generally implemented by applying anti-inflammatory drugs, steroid drugs and the like to patients, which can cause relatively high physiological burden to the patients; therefore, the invention provides an alternative solution of using natural burdock as a raw material to inhibit inflammation.

Description

Technical field [0001] The present invention relates to a use of burdock extract for preparing medicines for protecting elastic fibers and collagen, in particular to a use of burdock extract for preparing medicines to inhibit cell damage caused by inflammatory substances such as elastase and collagenase . Background technique [0002] Tendon is a kind of connective tissue, and its main component is composed of more collagen and less elastin. Tendon exists between human muscles and bones. Its main function is to make muscles power energy. Traction bones, and drive bones to move, so tendons are important physiological structures of the human body during activities. Many factors can cause tendinopathy, such as improper force when lifting heavy objects, long-term use of excessive load, impact, compression, etc., which may cause acute or chronic inflammation of the tendon. When the tendon is injured, the inflammatory substances elastase and collagenase will be produced. Reference P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P19/04A61P29/00A61K8/9789A61Q19/00A23L33/105
CPCA23V2002/00A61K8/97A61K36/28A61Q19/00A23V2200/316A23V2250/21
Inventor 吴彦廷鍾佳蓉周一呜蔡怡青黄大芹黄大芪
Owner 贝安股份有限公司
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