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Method for immobilizing natural antibacterial agent

A technology of natural antibacterial agents and carrier materials, applied in antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as lack of mature application technologies, achieve economical and feasible process paths, wide sources, and solve mildew change effect

Inactive Publication Date: 2018-04-17
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Relevant studies have shown that natural antibacterial agents are expected to play a role in safe animal breeding, but there is no mature application technology at present, especially antibacterial products that can solve both feed storage and use effects (CN 00807423.2; Microbiology Bulletin, 2016 , 43: 1339-1344)

Method used

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  • Method for immobilizing natural antibacterial agent
  • Method for immobilizing natural antibacterial agent
  • Method for immobilizing natural antibacterial agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Use high-speed stirring to prepare a suspension of attapulgite with a mass fraction of 2%, add zinc nitrate with a mass fraction of 10% to the dispersion, stir for 30 minutes, and let stand for 6 hours; then add the mass fraction dropwise to the system under mechanical stirring 2.5% sodium hydroxide solution until the zinc ions in the solution are completely deposited, centrifuged, dried, and calcined to obtain attapulgite-based composite nanostructure carrier materials; with the assistance of 300W ultrasonic waves, disperse 20% of its mass fraction in ethanol aqueous solution The carrier material and its mass fraction of 10% citral, the ratio of alcohol to water is 5:5; then shake in a constant temperature shaking box at 37°C for 24h, the mixture is centrifuged, dried at 60°C, ground, passed through a 200-mesh sieve, and packaged , to obtain attapulgite-based composite nanostructure immobilized natural antibacterial agent.

Embodiment 2

[0023] Embodiment 2: Adopt high-speed stirring to prepare a suspension of attapulgite with a mass fraction of 4%, add zinc chloride with a mass of 15% to the suspension, stir for 50min, and let stand for 3h; then add mass fraction to the system dropwise under mechanical stirring fraction of 5% sodium hydroxide solution until the zinc ions in the solution are completely deposited, centrifuged and dried to obtain the attapulgite-based composite nanostructure carrier material; The carrier material and thymol with a mass fraction of 20%, the ratio of alcohol to water is 6:4; then shake in a constant temperature shaking box at 37°C for 18h, the mixture is centrifuged, dried at 45°C, ground, passed through a 200-mesh sieve, and packaged. Attapulgite-based composite nanostructures were obtained to immobilize natural antibacterial agents.

Embodiment 3

[0024] Example 3: Using high-speed stirring to prepare a suspension of attapulgite with a mass fraction of 6%, adding zinc sulfate with a mass fraction of 20% to the suspension, stirring for 40min, and standing for 5h; then adding the mass fraction dropwise to the system under mechanical stirring 8% sodium hydroxide solution until the zinc ions in the solution are completely deposited, centrifuged and dried to obtain the attapulgite-based composite nanostructure carrier material; disperse the carrier with a mass fraction of 20% in ethanol aqueous solution under the assistance of 450W ultrasonic The material and its carvacrol with a mass fraction of 40%, the ratio of alcohol to water is 7:3; then shake in a constant temperature shaking box at 37°C for 18h, the mixture is centrifuged, dried at 45°C, ground, passed through a 200-mesh sieve, and packaged. Attapulgite-based composite nanostructures were obtained to immobilize natural antibacterial agents.

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PUM

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Abstract

The invention discloses a method for immobilizing a natural antibacterial agent. The method comprises the following steps: firstly preparing an attapulgite-based composite nanostructure carrier material, then sequentially dispersing the carrier material and the natural antibacterial agent into a certain ratio of ethanol aqueous solution under mechanical stirring and ultrasonication conditions, andthen shocking, centrifuging and drying at constant temperature, thus obtaining the attapulgite-based composite nanostructure carrier material. The method disclosed by the invention has the advantagesof cheap and available raw materials and simple operation, and the obtained nano composite antibacterial agent not only has broad-spectrum antibacterial property but also has high thermal stability and antibacterial persistence, is an antibacterial product respectively taking effect during storage and use of feed as a feed additive and can replace antibiotics used in an animal breeding process for a long time.

Description

technical field [0001] The invention relates to a method for immobilizing a natural antibacterial agent, belonging to the field of clay mineral functional materials. Background technique [0002] In recent years, the abuse of antibiotics and antibiotic pollution have become hot topics. [0003] Long-term use of antibiotics will reduce the diversity of intestinal microflora, destroy the dominant flora, cause the decline of animal immune function, increase mortality, and increase the number of drug-resistant bacteria (MBio, 2016, 7: e02039-15). The abuse and resistance of antibiotics in animals has become one of the major problems in the field of public health worldwide, posing a potential threat to human health. [0004] It is imminent to curb antibiotic pollution. Exploring feasible alternatives to antibiotics and providing feasible ways and technical support for antibiotic-free, green and healthy farming have become key common issues that need to be solved urgently in the ...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61K47/02A61K31/11A61K31/05A61K36/53A61P31/04A23K20/20A23K20/28A23K20/111A23K10/30A23K20/105
Inventor 王爱勤惠爱平康玉茹王文波牟斌
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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