Application of miRNA-4731-3p as diagnostic marker for primary lung cancer

Abstract

The invention relates to an application of circulating miRNA-4731-3p as a diagnostic marker for primary lung cancer, and method for detecting the miRNA-4731-3p. The miRNA-4731-3p having a high expression level, used as the target marker of experiments, is found through carrying out high-throughput screening on the kind of the circulating miRNA in the blood plasma of a patient diagnosed with the lung cancer and comparing the miRNA with corresponding miRNA in the blood plasma of a healthy control. The expression level of the miRNA-4731-3p is obviously higher than that of the control, and P is less than 0.001. An ROC curve analysis result shows that the usefulness AUC of the miRNA-4731-3p in the identification of normal people and a lung cancer patient is 0.048, the sensitivity is 95.0%, andthe specificity is 57.5%. A survival curve analysis result shows that the life is short if the expression level is high, and the life is long if the expression level is low.

Description

technical field [0001] The invention belongs to the technical field of medical diagnosis, and relates to the use of miRNA-4731-3p as a diagnostic marker for primary lung cancer. Background technique [0002] Worldwide, more than 1 million people die of lung cancer every year, ranking first among all malignant tumor-related deaths, of which 80% belong to non-small cell lung cancer (NSCLC). In China, in 2009, lung cancer ranked first among malignant tumors with an incidence rate of 53.57 / 100,000 and a mortality rate of 45.57 / 100,000. Although lung cancer diagnosis and treatment technology has been continuously improved in recent years, the 5-year survival rate of lung cancer patients has increased from 15% to 16.8%, but it is still one of the tumors with the worst prognosis. Lung cancer patients are also showing a younger trend. A few years ago, most lung cancer patients were over 55 years old, and few under 45 years old. However, in recent years, lung cancer patients under 4...

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