Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of apigenin to preparation of drugs capable of resisting Helicobacter pylori (Hp)

A technology against Helicobacter pylori and Helicobacter pylori, which can be used in antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve problems such as indigestion and the destruction of bacterial flora in the digestive tract

Inactive Publication Date: 2018-03-27
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacterial agents; another serious problem is that proton pump inhibitors can induce indigestion, and a large amount of antibacterial agents can lead to serious destruction of the intestinal flora

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of apigenin to preparation of drugs capable of resisting Helicobacter pylori (Hp)
  • Application of apigenin to preparation of drugs capable of resisting Helicobacter pylori (Hp)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of compound Apigenin tablet involved in the present invention:

[0016] Take 20 grams of compound Apigenin, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0017] Embodiment 2: the preparation of compound Apigenin capsules involved in the present invention:

[0018] Take 20 grams of compound Apigenin, add conventional auxiliary materials such as starch 180 grams for the preparation of capsules, mix well, and make 1000 capsules.

[0019] The following pharmacodynamic experiments will further illustrate its drug activity.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
Login to View More

Abstract

In vitro activity experiments showed that Apigenin has strong anti-Helicobacter pylori (Hp) activity. Apigenin can be used for the treatment of diseases such as acute and chronic gastritis, gastric and duodenal ulcers, and can be used in the preparation of medicines for treating acute and chronic gastritis, gastric and duodenal ulcers. The use of Apigenin involved in the present invention in the preparation of anti-Helicobacter pylori drugs is disclosed for the first time. Since the skeleton type belongs to a new skeleton type, and its inhibitory activity against Helicobacter pylori is unexpectedly strong, there is no inspiration from other compounds It is possible, has outstanding substantive features, and at the same time, it is obviously a significant progress in the prevention and treatment of Helicobacter pylori infection.

Description

technical field [0001] The present invention relates to a new application of the compound Apigenin, in particular to the application of Apigenin in the preparation of anti-helicobacter pylori drugs. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative spiral bacterium. Studies have shown that Helicobacter pylori is the main cause of acute and chronic gastritis and gastric and duodenal ulcers, and may be related to gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma. Recently, the World Health Organization classified Hp as a class I carcinogen, which plays a leading role in the development of gastric cancer. The current popular treatment for Hp infection is the triple therapy of taking proton pump inhibitor (PPI) plus two kinds of antibiotics (clarithromycin, amoxicillin, tetracycline, metronidazole, etc.) at the same time. The most important factor affecting triple therapy is considered to be the resistance of Hp to a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/48A61K9/20A61P31/04
CPCA61K31/352A61K9/2059A61K9/4866
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com