Application of deuterium-depleted water in glucose injection and glucose deuterium-depleted water injection
A technology of glucose injection and deuterium-depleted water, applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, drug delivery, etc. Deuterium water application and other problems, to achieve the effect of simple preparation method, accelerated metabolism in vivo, and sufficient metabolism in vivo
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[0025] The following are respectively the preparation methods of 5%, 10%, and 25% glucose deuterium-depleted water injection.
[0026] Weigh anhydrous glucose, dissolve it in deuterium-depleted water for injection of 1 / 3 of the total required amount, then add activated carbon for needles with a solution amount of 0.2% (W / V), boil for 15 minutes, add the remaining Use hydrochloric acid to adjust the pH to 4.5-5.0, stir for 15 minutes, take a sample of the intermediate for inspection, add deuterium-depleted water for injection to the full amount according to the content of the intermediate, stir for 20 minutes, and pass through 0.45 microns and 0.22 microns in turn. Filter through a pore filter, fill, and then sterilize at 115°C for 30 minutes to obtain glucose-deuterium-depleted water injection.
[0027] Preparation of 5% glucose deuterium-depleted water injection: Weigh anhydrous glucose 5g, dissolve it in 30ml deuterium-depleted water for injection, then add activated carbon ...
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