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Plant cellulose hollow capsule and preparation method thereof

A plant cellulose, hollow capsule technology, applied in the direction of capsule delivery, inorganic inactive ingredients, etc., can solve the problems of shortage of natural production raw materials, low water content of product raw materials, low qualified rate of finished products, etc. The effect of high dissolution rate

Pending Publication Date: 2018-03-13
湖南海洋胶囊有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] With the rapid increase in the consumption of plant capsules, there will be a shortage of single natural raw materials in the future, and the production process of plant-based hollow capsules is prone to low water content in product raw materials, resulting in poor fluidity and poor homogeneity, and then produces hollow capsules. Due to the different materials and wall thicknesses of the capsules, the qualified rate of finished products is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 5 parts of cold water and add it to the insulation barrel with 0.8% sodium alginate. After foaming for 1-3 hours, take another 45 parts of water and put it in the interlayer barrel. Add the recycled material while stirring, and heat it after it is completely dissolved. When the water temperature rises to 60-80°C, add the soaked sodium alginate solution, and when the temperature continues to rise to 80-100°C, take 10 parts of hypromellose (that is, 20% of the total mass of all ingredients), 50-500 rpm Slowly add it to water under stirring at a speed of 1 / min, and continue to stir evenly. When the temperature of the solution drops to 60-80°C, add 0.02% sodium lauryl sulfate and 0.10% polyethylene glycol 400, and continue stirring. When the temperature of the solution drops to 50-70°C, vacuumize for 0-4 hours, stop stirring and stand still for 0-3 hours, filter the glue solution and put it in a heat preservation bucket at 50-70°C for 6-10 hours, hang the prepared solut...

Embodiment 2

[0030]Take 5 parts of cold water and add it to the insulation barrel with 1.2% gellan gum. After soaking the gel for 1-3 hours, take another 40 parts of water and put it in the interlayer barrel. Heat the water temperature to 60-80°C and stir Next, add the return material, add the soaked gellan gum solution after it is completely dissolved, and when the temperature continues to rise to 80-100°C, take 10 parts of hypromellose (ie 22% of the total mass of all ingredients), and turn it at 50-500 Slowly add it into water under stirring at a speed of 1 / min, and keep stirring evenly. When the temperature of the solution drops to 60-80°C, add 0.15% sodium lauryl sulfate, 0.06% polyethylene glycol 400, and Potassium citrate, continue to stir, when the temperature of the solution drops to 50-70°C, vacuumize for 0-4 hours, stop stirring and stand still for 0-3 hours, filter the glue and put it in a heat preservation bucket at 50-70°C for 6- After 10 hours, hang the preparation solution ...

Embodiment 3

[0032] Take 5 parts of cold water and add it to the insulation barrel with 0.15% carrageenan and 0.1% gellan gum. After soaking the glue for 1-3 hours, take another 50 parts of water and put it in the interlayer barrel, and add the return material under stirring , after all dissolved, heat the water temperature to 60-80°C, add soaked carrageenan and gellan gum solution, continue to heat up to 80-100°C, take 10 parts of hypromellose (that is, the total mass of all ingredients 18% of 18%), 50-500 rpm stirring speed slowly added to the water, continue to stir evenly, when the temperature of the solution drops to 60-80 ° C, add 0.02% sodium lauryl sulfate, 0.10% Polyethylene glycol 400, 0.06% potassium citrate, continue to stir, when the temperature of the solution drops to 50-70°C, vacuumize for 0-4 hours, stop stirring for 0-3 hours, filter the glue solution and then set aside at 50-70°C Stand still in the heat preservation barrel at ℃ for 6-10 hours, hang the preparation liquid...

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Abstract

The invention discloses a plant cellulose hollow capsule, which is composed of the following raw materials in percentage by weight: 10 to 40% of hydroxypropyl methyl cellulose, 0.1 to 5% of coagulantaid, 0 to 0.5% of surfactant, 0 to 0.5% of emulsifier, 0 to 0.5% of coloring agent, 0 to 3% of titanium dioxide, and the balance being water. The invention also provides a preparation method of the plant cellulose hollow capsule. The preparation method comprises following steps: (1) mixing; (2) adding raw materials and auxiliary agents; (3) preparing a solution; and (4) moulding. The friability, disintegration performance, and light transmittance of the plant cellulose hollow capsule all meet the standards of pharmaceutical capsules. The raw materials of the plant cellulose hollow capsule areall plants, the performance is stable, the water content is low, and furthermore, the hollow capsule does not participate in human metabolism, is green, environmentally-friendly, and safe, and is suitable for filling various contents.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical excipients, and in particular relates to a plant cellulose hollow capsule and a preparation method thereof. Background technique [0002] The industrial manufacture of traditional hollow capsules is most preferably gelatin, which is derived from collagen in animal skin, tendons, and bone marrow, and is a partially hydrolyzed protein from the collagen of animal connective tissue or epidermal tissue. Due to its characteristics of gelling, film-forming and surface activity, gelatin hollow capsules have certain temperature and humidity requirements for the production, transportation and storage of capsule preparations, and are not suitable for hygroscopic drugs, water-sensitive drugs, base-containing drugs, Production, storage and transportation of capsule preparations for vegetarians, high temperature areas. [0003] With the frequent outbreaks of global animal epidemics in recent years, soft...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38A61K47/02
CPCA61K47/02A61K47/38A61K9/4816
Inventor 王玉明王焕庭宋磊陈贺冯清辉曹丽湘周后新王峰
Owner 湖南海洋胶囊有限公司
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