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Adhesive bandage and preparation and use methods of adhesive bandage

A band-aid and medical technology, applied in the field of nano-biomedicine, can solve problems such as adverse reactions, achieve good therapeutic effect, reduce drug dosage, and high near-infrared light absorption

Inactive Publication Date: 2018-03-06
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although benzalkonium chloride, the active ingredient of Band-Aid, has excellent antibacterial activity, it can cause some adverse reactions, such as allergic rhinitis and drug-induced rhinitis, etc.

Method used

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  • Adhesive bandage and preparation and use methods of adhesive bandage
  • Adhesive bandage and preparation and use methods of adhesive bandage
  • Adhesive bandage and preparation and use methods of adhesive bandage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method for a band-aid, comprising the steps of:

[0023] (1) Preparation of gold nanocluster-graphene composite material Dissolve 40 mg bovine serum albumin BSA in 6 mL water, then add 800 μL 20 mM chloroauric acid and 3 mL water, mix for 5 min, then add 400 μL 1M NaOH, stirred at 37 °C for 12 h to prepare gold nanoclusters. Then 50 μg / mL graphene oxide was reacted with 1 nM gold nanoclusters in phosphate buffer (25 mM, pH 7.0) for 10 min at room temperature to prepare gold nanoclusters-graphene composites.

[0024] (2) Preparation of Band-Aids Install square medical cotton on the negative pressure filtration device, add the gold nanocluster-graphene composite material solution with a concentration of 1.5 mg / mL prepared in the previous step, and let the solution pass through the medical cotton. Repeat the suction filtration process until the solution is completely absorbed by the medical cotton. 400 μL of 10 mg / mL ascorbic acid was added dropwise, and th...

Embodiment 2

[0026] A preparation method for a band-aid, comprising the steps of:

[0027] (1) Preparation of gold nanocluster-graphene composite material Dissolve 30 mg bovine serum albumin BSA in 6 mL water, then add 800 μL 20 mM chloroauric acid and 3 mL water, mix for 5 min, then add 450 μL 1M NaOH, stirred at 37 °C for 12 h to prepare gold nanoclusters. Then 40 μg / mL graphene oxide was reacted with 1 nM gold nanoclusters in phosphate buffer (25 mM, pH 7.0) for 10 min at room temperature to prepare gold nanoclusters-graphene composites.

[0028] (2) Preparation of Band-Aids Install square medical cotton on the negative pressure filtration device, add the gold nanocluster-graphene composite material solution with a concentration of 1.5 mg / mL prepared in the previous step, and let the solution pass through the medical cotton. Repeat the suction filtration process until the solution is completely absorbed by the medical cotton. 300 μL of 10 mg / mL ascorbic acid was added dropwise, and th...

Embodiment 3

[0030] A preparation method for a band-aid, comprising the steps of:

[0031] (1) Preparation of gold nanocluster-graphene composite material Dissolve 50 mg bovine serum albumin BSA in 6 mL water, then add 800 μL 20 mM chloroauric acid and 3 mL water, mix for 5 min, then add 500 μL 1M NaOH, stirred at 37 °C for 12 h to prepare gold nanoclusters. Then 60 μg / mL graphene oxide was reacted with 1 nM gold nanoclusters in phosphate buffer (25 mM, pH 7.0) for 10 min at room temperature to prepare gold nanoclusters-graphene composites.

[0032] (2) Preparation of Band-Aids Install square medical cotton on the negative pressure filtration device, add the gold nanocluster-graphene composite material solution with a concentration of 1.5 mg / mL prepared in the previous step, and let the solution pass through the medical cotton. Repeat the suction filtration process until the solution is completely absorbed by the medical cotton. 500 μL of 10 mg / mL ascorbic acid was added dropwise, and th...

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PUM

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Abstract

The invention provides a novel method for disinfecting a wound through a gold nanocluster-graphene composite (AuNCs-Go) and ascorbic acid (AA) based adhesive bandage. The gold nanocluster-graphene composite is high in near-infrared ray (NIR) absorption and peroxidase activity, and can effectively catalyze a high-antibacterial activity hydroxyl radical produced in the decomposition of hydrogen peroxide produced by the prodrug ascorbic acid, so that the toxicity of the high-concentration hydrogen peroxide is avoided. The adhesive bandage has the chemotherapy / photo-thermal synergic treatment effects, and a designed antibacterial system has a broad spectrum and an efficient antibacterial activity, so that the healing of the wound is accelerated.

Description

technical field [0001] The invention relates to the field of nano-biomedicine, in particular to a band-aid and a method for preparing and using the same. Background technique [0002] At present, infectious diseases caused by bacteria are still one of the biggest health problems in the world, which plagues millions of people every year. Therefore, antibacterial materials are widely used in daily life and effectively protect public health. Traditional antibacterial strategies are mainly based on antibiotics, metal ions, and quaternary ammonium salts, all of which have disadvantages such as ecotoxicity, high cost, and environmental hazards. In addition, hydrogen peroxide (H 2 o 2 ) is also widely used as a disinfection agent, however, the traditional concentration of hydrogen peroxide (volume ratio: 0.5–3%) hinders wound healing during bacterial disinfection and even damages normal tissues. Band-aids are widely used to cover wounds and prevent bacterial infections. Althoug...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/46A61L15/18A61L15/20
CPCA61L15/18A61L15/20A61L15/44A61L15/46A61L2300/102A61L2300/108A61L2300/216A61L2300/404
Inventor 冀海伟王仁亮翟静冯蕾
Owner TAISHAN MEDICAL UNIV
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