Preparation method of ethyl 6,8-dichlorocaprylate

Abstract

The invention discloses a preparation method of ethyl 6,8-dichlorocaprylate. The preparation method is characterized in that cyclohexanone and vinyl ether which are cheap in price are mainly taken asbasic raw materials; the basic raw materials are then subjected to free-radical addition, so that 2-(2'-ethoxyethyl)cyclohexanone is obtained; secondly, the 2-(2'-ethoxyethyl)clohexanone is subjectedto oxidation, hydrolysis and acidification reaction, so that 8-ethoxyl-6-hydroxyl-octanoic acid is obtained. The synthetic raw materials adopted by the preparation method are low in whole price, and the synthesis method is simple; the step of chlorination can be effectively omitted at the same time, so that pollution is reduced; furthermore, the overall synthetic route is safe, and major safety accidents are avoided; therefore, the preparation method provided by the invention has the advantages of being economical, reasonable, safe and free from pollution.

Description

technical field [0001] The invention relates to the field of chemical synthesis, in particular to a preparation method of ethyl 6,8-dichlorooctanoate. Background technique [0002] Lipoic acid is a coenzyme found in mitochondria, similar to vitamins, which can eliminate free radicals that lead to accelerated aging and disease. Alpha lipoic acid enters the cells after being absorbed by the intestines in the body, and has both fat-soluble and water-soluble properties. [0003] Lipoic acid belongs to a class of compounds in B vitamins, a growth factor for yeast and some microorganisms, and acts as a coenzyme in a multi-enzyme system, catalyzing the oxidative decarboxylation of pyruvate into acetic acid and the oxidative decarboxylation of α-ketoglutarate into succinic acid Transacyl effect. [0004] As a coenzyme, lipoic acid plays a role in two key oxidative decarboxylation reactions, that is, in the pyruvate dehydrogenase complex and the α-ketoglutarate dehydrogenase comple...

AI Technical Summary

Problems solved by technology

[0005] Ethyl 6,8-dichlorooctanoate is an important intermediate for the preparation of lipoic acid. At present, the method for preparing ethyl 6,8-dichlorooctanoate mainly adopts the method of monoethyl adipate. The raw material of this process is monoethyl adipate The price is more expensive, and at the same time, ethylene with a very low boiling point must be used, which is not safe and difficult to control. In addition, it has to go through multi-step chlorination and the pollution is serious, so it is not an ideal synthetic route.

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