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Oligopeptide wound dressing for promoting healing of diabetic wound and preparation method of oligopeptide wound dressing

A wound healing and oligopeptide technology, applied in medical science, bandages, etc., can solve the problems affecting the safety and effectiveness of dressings, the degradation rate is not easy to control, and the existence of infection, so as to achieve good wound healing activity and solve poor solubility , high safety effect

Active Publication Date: 2018-02-09
河南东肽生物有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dressings made of collagen, the main disadvantages of collagen are poor elasticity, brittle quality, water resistance, easy to be eroded by bacteria and deteriorate in humid environment, the degradation rate is not easy to control, and there is a risk of infection because it is derived from animals
However, chemical residues (such as sterilizing agents, adjuvants, crosslinking agents, excipients, residual monomers, etc.), impurities (such as heavy metals, miscellaneous proteins, etc.), degradation products, and drug release in pharmaceutical dressings etc. If these indicators are not properly controlled, they will affect the safety and effectiveness of the final use of the dressing
[0004] Chinese patent (CN102228715A) discloses a liquid dressing containing chitosan derivatives and its preparation method. Chinese patent (CN104667335A) discloses a recombinant human collagen product with skin barrier function and its preparation method. Although the dressing contains Collagen, but because the molecular weight of collagen is too large, the solubility is small and the stability is poor. This liquid dressing uses chemically synthesized preservatives and antibacterial agents, so the safety is also worthy of consideration
Although the development of biological dressings is very rapid, there is still no dressing that can meet the requirements of ideal dressings, and various types of dressings have their insurmountable shortcomings

Method used

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  • Oligopeptide wound dressing for promoting healing of diabetic wound and preparation method of oligopeptide wound dressing
  • Oligopeptide wound dressing for promoting healing of diabetic wound and preparation method of oligopeptide wound dressing
  • Oligopeptide wound dressing for promoting healing of diabetic wound and preparation method of oligopeptide wound dressing

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Experimental program
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Effect test

Embodiment 1

[0049] A kind of oligopeptide wound dressing that promotes diabetic wound healing, the mass percentage of its each component is as follows:

[0050] Sea cucumber oligopeptide 40%,

[0051] Bovine bone oligopeptide 30%,

[0052] Ginseng Oligopeptide 2%,

[0053] Glycerin 10%,

[0054] Water-soluble Vitamin E 5%,

[0055] borneol 5%,

[0056] The balance is medical purified water.

[0057] Among them, the sea cucumber oligopeptide is a small molecule biologically active peptide obtained by enzymolysis and separation from liao cucumber by biomimetic extraction technology, and its preparation includes the following steps: extraction treatment, enzyme inactivation treatment, clarification treatment, separation treatment and drying treatment. The extraction process uses alkaline protease (2.4AU / g, Novozymes). The extraction conditions were as follows: extraction temperature 50°C, extraction time 4 hours, pH 8, extraction solid-liquid ratio 1:20, enzyme addition amount 1:500 ma...

Embodiment 2

[0071] A kind of oligopeptide wound dressing that promotes diabetic wound healing, the mass percentage of its each component is as follows:

[0072] Sea cucumber oligopeptide 50%,

[0073] Bovine bone oligopeptide 25%,

[0074] Ginseng Oligopeptide 5%,

[0075] Propylene Glycol 10%,

[0076] Citric Acid 8%,

[0077] Menthol 1%,

[0078] The balance is medical purified water.

[0079] Among them, the sea cucumber oligopeptide is a small molecule biologically active peptide obtained by enzymolysis and separation from liao cucumber by biomimetic extraction technology, and its preparation includes the following steps: extraction treatment, enzyme inactivation treatment, clarification treatment, separation treatment and drying treatment. The extraction process uses neutral protease (0.8AU / g, Novozymes, Denmark). The extraction conditions were as follows: extraction temperature 40°C, extraction time 6 hours, pH 7, extraction solid-liquid ratio 1:20, enzyme addition amount 1:20...

Embodiment 3

[0093] A kind of oligopeptide wound dressing that promotes diabetic wound healing, the mass percentage of its each component is as follows:

[0094] Sea cucumber oligopeptide 40%,

[0095] Bovine bone oligopeptide 25%,

[0096] Ginseng Oligopeptide 1%,

[0097] Polyethylene glycol 5%,

[0098] Menthol and Peppermint Oil 5%,

[0099] Borneol 1%,

[0100] The balance is absolute ethanol.

[0101] Among them, the sea cucumber oligopeptide is a small molecule biologically active peptide obtained by enzymolysis and separation from liao cucumber by biomimetic extraction technology, and its preparation includes the following steps: extraction treatment, enzyme inactivation treatment, clarification treatment, separation treatment and drying treatment. The extraction process uses alkaline protease (2.4AU / g, Novozymes, Denmark), neutral protease (0.8AU / g, Novozymes, Denmark), alkaline protease: neutral protease=1:1 (mass ratio) . The extraction conditions were as follows: extract...

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Abstract

The invention belongs to the technical field of medical preparations and particularly relates to an oligopeptide wound dressing for promoting healing of a diabetic wound and a preparation method of the oligopeptide wound dressing. The oligopeptide wound dressing takes holothurian holothurian and bovine bone collagen oligopeptide as the main ingredients and ginseng oligopeptide as the auxiliary material, and is a liquid dressing prepared from the main ingredients, the auxiliary materials, a humectant, a permeation accelerant, a cooling and refreshing ingredient and a dressing solvent. The dressing takes the purely naturally extracted holothurian holothurian, bovine bone collagen oligopeptide and ginseng oligopeptide as the main materials, chemosynthetic preservatives or bacteriostatic agents are not added, and the oligopeptide wound dressing improves the postoperation nutritional condition of a patient and effectively promotes the healing of the wound after being applied to the postoperation of the diabetes patient, and has the effects of inhibiting bacteria, diminishing inflammation and resisting oxidation.

Description

technical field [0001] The invention belongs to the technical field of medical preparations, and in particular relates to a composition of an oligopeptide wound dressing for promoting diabetic wound healing and a preparation method thereof. Background technique [0002] As a chronic disease, complications caused by diabetes are an important cause of death or disability, including diabetic microangiopathy, diabetic nephropathy, and diabetic neuropathy. Among the many complications of diabetes, the impaired wound healing ability of diabetic patients is a very typical complication. If the chronic damage of diabetic patients occurs in the foot, it may lead to diabetic foot, and in the most serious case, it may lead to amputation of the patient. This has become the disease with the highest hospitalization rate of diabetic patients. There are even reports showing One patient had a limb amputated due to diabetes. If the impaired wound healing ability caused by diabetes can be eff...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0028A61L26/0066A61L2300/25A61L2300/404A61L2300/412C08L89/00
Inventor 李勇樊蕊
Owner 河南东肽生物有限公司
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