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Preparation method of high-viscosity material particles of extracts

An extract-based, high-viscosity technology, which is applied in the field of wet granulation preparation, can solve the problems of large particle powder, inconvenient granulation, inconvenient operation, etc., and achieve uniform particle shape, convenient formula deployment, and obvious optimization effect Effect

Inactive Publication Date: 2018-02-09
JIANGSU ALAND NOURISHMENT
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Problems solved by technology

[0002] From a medical point of view, extracts are generally divided into plant extracts (including Chinese medicine extracts or herbal medicine extracts), animal extracts; and in the usual sense, we can generally understand extracts as plant extracts, Chinese medicine extracts, animal extracts, etc. There are three types of extracts; we all know that there are many varieties of plant and herbal raw materials, the market is relatively chaotic, lack of standardized production and quality standards, and the content of functional ingredients and product quality are relatively uncontrollable; According to the needs of the use, through modern equipment and technology, through the process of physical and chemical extraction and separation, one or more active ingredients in animal and plant raw materials are directional obtained and concentrated without changing the structure of the active ingredients; but extraction Most of the products are powders that stick to water, which is inconvenient to granulate to form follow-up products. It is not easy to granulate when using organic solvents. Even if a small amount of water is added to the organic solvent, a large amount of lumps will form when granulating.
In reality, the granulation of the extract still follows the granulation method of old Chinese medicine. After adding water-containing ethanol, a soft material with agglomerates is formed, and then it is forcibly granulated with a swing granulator, or dried with a swing granulator Forced granulation, this method of granulation is not good, and the production capacity is low; there are also dry granulation, but the dry granulation has a lot of granule powder, the particle size and hardness are not good, the disintegration of the tablet compressed by the granules is not good, and the production capacity is low. Not high, in addition, the extract is easy to stick to the roller, which is inconvenient to operate
After searching the relevant information at home and abroad, there is no good wet granulation method to produce extract-like high-viscosity material particles. Therefore, a preparation method is needed, which can not only produce qualified and high-quality particles, but also has high production efficiency. Large production capacity

Method used

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  • Preparation method of high-viscosity material particles of extracts

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preparation example Construction

[0019] A method for preparing extract-like high-viscosity material particles is characterized in that it mainly includes the following steps:

[0020] Step ①: Prepare solid slurry; in step ①, use a non-viscous and less viscous base material and put it into a high-speed wet mixing granulator, add a wetting agent, and wet the base material to form a solid slurry; The base material is one or a combination of at least two of silicon dioxide, glucosamine hydrochloride, glucose, anhydrous calcium hydrogen phosphate powder, microcrystalline cellulose, malic acid, sodium chloride, potassium chloride; The wetting agent is one or a combination of purified water, ethanol, and isopropanol; the amount of the wetting agent is 0.3 to 3 times the amount of the base material;

[0021] Step ②: Stirring and mixing of high-viscosity main ingredients;

[0022] Step ③: Add solid slurry in step ②, and granulate;

[0023] Step ④: drying, dry material granulation;

[0024] Step ⑤: Sieve test; in st...

Embodiment 1

[0028] formula:

[0029] Chrysanthemum extract: 200 parts (high viscosity);

[0030] Radix Seed Extract: 300 parts (very viscous);

[0031] Silica: 50 parts;

[0032] 1. Put 50 parts of silicon dioxide into a high-speed wet mixing granulator, add an appropriate amount of water to disperse and chop, and form a solid slurry to release;

[0033] 2. Put the extract in the formula into the high-speed wet mixing granulator for mixing, put in the solid slurry released earlier, and at the same time quickly close the machine cover, open the granulation system for granulation until satisfactory granules are produced;

[0034] 3. After the prepared granular soft material is fluidized and dried, the dry material is fully granulated;

[0035] 4. Carry out sub-sieving test, test with 20, 40, 60, 80, and 100 mesh sieves respectively, 2.5% for 20 mesh upper sieve, 35.8% for 20~40 mesh, 21.5% for 40~60 mesh, 21.5% for 60~80 mesh 16.6%, 9.2% for 80-100 mesh, 14.4% for 100-mesh sieve, the fi...

Embodiment 2

[0039]

[0040] 1. Put 45.27 parts of anhydrous calcium hydrogen phosphate powder and 12 parts of microcrystalline cellulose into a high-speed wet mixing granulator to stir and mix, and at the same time add an appropriate amount of water to disperse and chop to form a solid slurry;

[0041] 2. Mix the various extracts in the table formula evenly in the mixer first, release 42.73 parts, put them into the solid slurry of anhydrous calcium hydrogen phosphate powder and microcrystalline cellulose, and turn on the granulation system in time for granulation. until satisfactory particles are made;

[0042] 3. After the prepared granular soft material is fluidized and dried, the dry material is fully granulated;

[0043] 4. Carry out sub-sieving test, use 20, 40, 60, 80, and 100 mesh sieves to test respectively, 20 mesh upper sieve is 4.0%, 20~40 mesh is 36.2%, 40~60 mesh is 21.5%, 60~80 mesh It is 14.2%, 80-100 mesh is 8.2%, and 100-mesh sieve is 15.9%. The fineness distribution ...

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Abstract

The invention discloses a preparation method of high-viscosity material particles of extracts. The preparation method mainly comprises following steps: step 1, preparation of solid slurry; step 2, stirring and mixing for a high-viscosity main material; step 3, addition of the solid slurry to the high-viscosity main material and granulation. Specifically, firstly, a base material is wetted by a wetting agent, the base material is a non-viscous material or a material with a little viscosity, the solid slurry is formed and then added to the high-viscosity main material or the high-viscosity mainmaterial is added to the solid slurry, and with the adoption of a high-speed wet mixed granulation mode, solids and liquids after dispersive mixing are contacted to be sticky and are bonded to form particles; the formed particles are uniform in shape, high in granulating ratio, tightly combined, high in production efficiency and high in capacity; tablets prepared from the particles are high in hardness, fast to disintegrate and remarkable in effect.

Description

technical field [0001] The present invention relates to the technical field of biological and new medical material extraction and wet granulation, in particular, it relates to a method of wetting the powder with a wetting agent to form a solid slurry, and then wetting the viscous material in the extract. Preparation method of French granulation. Background technique [0002] From a medical point of view, extracts are generally divided into plant extracts (including Chinese medicine extracts or herbal medicine extracts), animal extracts; and in the usual sense, we can generally understand extracts as plant extracts, Chinese medicine extracts, animal extracts, etc. There are three types of extracts; we all know that there are many varieties of plant and herbal raw materials, the market is relatively chaotic, lack of standardized production and quality standards, and the content of functional ingredients and product quality are relatively uncontrollable; According to the needs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/16
CPCA61K9/1682A61K9/2095
Inventor 倪国成张国栋史解矛夏旭东张勇吴名草陈铖钱文栋
Owner JIANGSU ALAND NOURISHMENT
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