Captopril tablet for treating hypertension cardiac failure and application

A technology for heart failure and high blood pressure, applied in the field of medicine, can solve the problems of heart failure without obvious curative effect and unsatisfactory effect, increase safety and patient compliance, reduce the dosage of single use, and significantly reverse the effect Effect

Inactive Publication Date: 2018-02-02
NANJING ZHENGKUAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although many antihypertensive drugs can effectively reduce the blood pressure of patients, they have no obvious effect on heart failure in hypertensive patients. Only a few antihypertensive drugs, such as angiotensin converting enzyme inhibitors, angiotensin Although receptor antagonists can reverse heart failure in patients, the effect is not very satisfactory

Method used

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  • Captopril tablet for treating hypertension cardiac failure and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: Take captopril 125g, forsythin 250g, microcrystalline cellulose 30g, sodium carboxymethyl starch 20g and magnesium stearate 5g, the preparation method comprises the following steps: take the above-mentioned raw materials and filler, disintegrate agent, pulverized, sieved, granulated with 75% ethanol, added magnesium stearate, and compressed into tablets.

Embodiment 2

[0020] Embodiment 2: take captopril 125g, forsythin 375g, starch 30g, croscarmellose sodium 20g and talcum powder 5g, the preparation method comprises the following steps: take the above-mentioned raw materials and filler, disintegrant, Crush, sieve, granulate with 75% ethanol, add magnesium stearate, and compress into tablets.

Embodiment 3

[0021] Embodiment 3: Take captopril 125g, forsythin 312.5g, starch 30g, croscarmellose sodium 20g and talcum powder 5g, the preparation method comprises the following steps: take the above-mentioned raw materials and filler, disintegrant , pulverized, sieved, granulated with 75% ethanol, added magnesium stearate, and compressed into tablets.

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PUM

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Abstract

The invention provides a captopril tablet for treating hypertension cardiac failure. The captopril tablet contains captopril and forsythin, active ingredients are formed by the captopril and forsythin, and a corresponding preparation method is used. The captopril tablet has the efficacy of synergistically treating the hypertension and cardiac failure.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a captopril tablet for treating hypertensive heart failure and its application. Background technique [0002] Hypertension (hypertension) refers to an increase in systemic arterial blood pressure (systolic and / or diastolic) as the main feature (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney, etc. Clinical syndrome of functional or organic damage to organs. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. The blood pressure of a normal person fluctuates within a certain range with changes in the internal and external environment. In the whole population, the blood pressure level gradually increases with age, especially the systolic blood pressure, but the diastolic blood pressure shows a downward trend after the age of...

Claims

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Application Information

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IPC IPC(8): A61K31/401A61K31/7048A61K9/20A61P9/12A61P9/04
CPCA61K9/2059A61K31/401A61K31/7048A61K2300/00
Inventor 李洋
Owner NANJING ZHENGKUAN MEDICAL TECH
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