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Quality control method of rhizoma gastrodiae, decoction piece thereof and rhizoma gastrodiae extract

A quality control method and extraction technology, which is applied in the direction of measuring devices, material separation, and analysis materials, etc., can solve the problem of the inability to fully control the quality of Gastrodia elata medicinal materials and their decoction pieces and extracts, and the instability of Gastrodia elata parisonoside components reference substances , high detection sensitivity and other issues, to achieve the effect of low price, quality control of Gastrodia elata, and high detection sensitivity

Inactive Publication Date: 2018-01-30
王信
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has high detection sensitivity and good stability, and can objectively, comprehensively and accurately evaluate the quality of Gastrodia elata medicinal materials and their decoction pieces and extracts, and can solve the factors such as instability and high price of Gastrodia elata barison glycosides, which cannot be fully controlled The problem of the quality of Gastrodia elata medicinal materials and its decoction pieces and extracts is of great significance to control the quality of Gastrodia elata and ensure the curative effect

Method used

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  • Quality control method of rhizoma gastrodiae, decoction piece thereof and rhizoma gastrodiae extract
  • Quality control method of rhizoma gastrodiae, decoction piece thereof and rhizoma gastrodiae extract
  • Quality control method of rhizoma gastrodiae, decoction piece thereof and rhizoma gastrodiae extract

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Embodiment Construction

[0023] The method for quality control of a Gastrodia elata medicinal material and its decoction pieces and extracts of the present invention will be further described below in conjunction with specific examples.

[0024] 1 material

[0025] Agilent 1260 high-performance liquid chromatography (Agilent Co., Ltd.); AB135-S one-hundred-thousandth balance (Swiss Mettler-Toledo Instrument Co., Ltd.); EP214C one-thousandth electronic balance (Swiss Mettler Teller-Toledo Instrument Co., Ltd.); KQ-250 Ultrasonic Cleaner (Kunshan Ultrasonic Instrument Co., Ltd.).

[0026] Gastrodin reference substance (110807-201306) was purchased from China Institute for the Control of Pharmaceutical and Biological Products; barisenoside A, B, C, E (purity>98%) were purchased from Chengdu Master Biotechnology Co., Ltd.; acetonitrile, phosphoric acid It is chromatographically pure, water is purified water, and other reagents are analytically pure.

[0027] Fifteen batches of Gastrodia elata were colle...

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Abstract

The invention relates to a quality control method of rhizoma gastrodiae, a decoction piece thereof and rhizoma gastrodiae extract. Based on high-performance liquid chromatography, by the aid of a one-standard multi-measurement analysis method, the contents of gastrodin components of gastrodin, p-hydroxybenzyl alcohol, parishin A, parishin B, parishin C and parishin E in the rhizoma gastrodiae arecalculated by relative correction factors, the low-cost gastrodin with stable property serves as an internal standard substance, and six effective components in the rhizoma gastrodiae are simultaneously measured. The multi-index quality control method is high in detection sensitivity, rapid in analysis and good in stability, can objectively, comprehensively and accurately evaluate the quality of the rhizoma gastrodiae, the decoction piece thereof and the rhizoma gastrodiae extract, is of great significance for ensuring the curative effect of the rhizoma gastrodiae and can solve the problems that parishin component reference substances are unstable, high in price and the like, and the quality of the rhizoma gastrodiae, the decoction piece thereof and the rhizoma gastrodiae extract cannot becomprehensively controlled.

Description

technical field [0001] The invention relates to a quality control method, in particular to a method for quality control of Gastrodia elata medicinal material and its decoction pieces and extracts. Background technique [0002] Gastrodia elata is the dry tuber of Gastrodia elata BL., a plant in the family Orchidaceae. It has the effects of calming liver yang, dispelling wind and dredging collaterals. At present, it is generally believed that gastrodin is an important active ingredient of Gastrodia elata. Studies in recent years have found that Gastrodia elata also has neuroprotective effects such as increasing intelligence and strengthening the brain, and has certain curative effects on senile dementia. Modern pharmacological studies have shown that components such as barisenoside C and barisenoside B in Gastrodia elata have the effect on scopolamine. The learning and memory impairment caused by vascular dementia and the learning and memory impairment caused by vascular deme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
Inventor 王信李莉刘天易
Owner 王信
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