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Preparation method of nano anti-tissue-adhesion fiber membrane having anti-tumor function

A technology of tissue adhesion and fiber membrane, applied in the fields of fiber chemical characteristics, non-woven fabrics, textiles and papermaking, etc., can solve the problems of immune system cancer cell erosion, lower patient resistance, high cancer mortality and other problems

Inactive Publication Date: 2018-01-19
DALIAN JIAOTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Surgical resection, radiotherapy, and chemotherapy have always been the traditional means of cancer treatment, but surgical resection cannot completely cure cancer, and although radiotherapy and chemotherapy drugs are constantly improving, they can still cause great damage to normal cells and body functions , reduce the patient's own resistance, and cause the patient's immune system to be eroded by cancer cells, which leads to high mortality rates of cancer recurrence, and also makes multiple recurrences of cancer in situ a rather difficult task in today's medical recovery process. one of the problems

Method used

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  • Preparation method of nano anti-tissue-adhesion fiber membrane having anti-tumor function
  • Preparation method of nano anti-tissue-adhesion fiber membrane having anti-tumor function

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Experimental program
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Embodiment 1

[0020] Embodiment 1 (gelatin / PEO / NaYF 4 :Er / Yb composite nano anti-adhesion film)

[0021] With gelatin and polyethylene oxide (PEO) as raw materials, formic acid as solvent, gelatin is dissolved in formic acid solvent at room temperature, and the stirred solution is uniform and transparent, wherein the mass fraction of gelatin is 5%, and the mass fraction of PEO is 1 % followed by the addition of upconverting nanoparticles NaYF 4 : Er / Yb, its relative gelatin mass ratio is 5%. The above solution was left standing to remove air bubbles and used as a spinning stock solution, which was injected into a syringe. The solution flow rate is precisely controlled by a syringe pump, and the solution flow rate is 0.6ml / h. Electrospinning was carried out under the conditions of 12KV voltage and a distance of 12cm between the spinneret and the receiver (aluminum film). The collection time is 48 hours. The thickness of the collected fibrous web material is about 2 mm, and vacuum-dried ...

Embodiment 2

[0022] Embodiment 2 (chitosan / Y 2 o 3 :Er / Yb composite anti-adhesion film)

[0023] Using glacial acetic acid or trifluoroethanol as a solvent, prepare a chitosan solution with a mass fraction of 5% to 30%, and prepare the up-converting nanoparticles Y 2 o 3 : Er / Yb is added in this solution, and its mass ratio is 3% relative to chitosan. The spinning voltage can be adjusted between 15KV as required, the collection distance is 5-15cm, and the solution flow rate is 1.0ml / h. The solution flow rate is precisely controlled by a syringe pump. The collection time is 4-72 hours. The thickness of the collected fiber web material is continuously adjustable between hundreds of microns and 3 mm, and then vacuum-dried for 8 hours to obtain chitosan / Y 2 o 3 : Er / Yb nanofibrous web.

Embodiment 3

[0024] Embodiment 3 (PLGA / NaYF 4 :Tm / Yb composite fiber anti-adhesion film)

[0025] Using polylactide (PLGA) as a raw material, DMF as a solvent, and configuring a PLGA solution with a mass fraction of 20%, the upconversion nanoparticles NaYF 4 : Tm / Yb, its relative PLGA mass fraction is 5%. The spinning stock solution was injected into the syringe, the spinning voltage was adjusted between 10-20KV as required, the collection distance was 15cm, and the solution flow rate was 1.0ml / h. The solution flow rate is precisely controlled by a syringe pump. The collection time is 72 hours. The thickness of the collected fibrous web material is about 2 mm, and vacuum-dried for 8 h to obtain PLGA / NaYF 4 : Tm / Yb composite nanofibrous web.

[0026] After tumor lesion tissue is resected, the novel anti-adhesion film with anti-tumor function prepared by the present invention is directly placed on the resected tumor site, and the wound is sutured. For patients with cancer recurrence in...

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Abstract

The invention discloses a preparation method of a nano anti-tissue-adhesion fiber membrane having an anti-tumor function. Soluble nano-fibers, which have hemostasis effect, are prepared through electro-spinning technology in a compounding manner from raw materials including: up-conversion luminescent nano-particles, such as NaYF4:Er / Yb, NaYF4:Tm / Yb, YVO4:Er / Yb, NaYF4:Sm / Nd, which have anti-cancereffects, and a hemostasis medicine, such as Baquting, hemocoagulase and aminomethylbenzoic acid, etc. During a process of excision of cancer lesions, quick hemostasis is achieved, and tissue adhesionis prevented during postoperation. Through the optical-thermal physical therapy function of the up-conversion luminescent nano-particles, in-situ recurrence of cancer tissue is inhibited.

Description

technical field [0001] The invention relates to a preparation method of a nano anti-tissue adhesion fiber membrane with anti-tumor function. Background technique [0002] Adhesions are abnormal structures where fibrous bands of connective tissue join together with adjacent tissues or organs. After surgery, tissue adhesion is prone to occur, which is not only a common clinical phenomenon in the field of surgery, but also a process that patients must go through during the healing process. If adhesions occur in the abdominal cavity, pelvic bone and other operations, it will cause serious complications, such as adhesive ileus, female infertility caused by pelvic tissue adhesions, and adhesions after thyroid surgery can cause damage to the recurrent laryngeal nerve. At present, there are two ways to prevent postoperative tissue adhesion at home and abroad, one is a treatment method based on physiological and pharmacological mechanisms, mainly drugs to reduce inflammatory reactio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/04A61L31/06D04H1/728D01F4/00D01F6/92D01F9/00D01F1/10
Inventor 于洪全唐雁宁盛臣臣王韶旭兰喜杰梁占国庞雅茹王欣欣
Owner DALIAN JIAOTONG UNIVERSITY
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