Injectable gel material for spinal repair

A gel material, spine technology, applied in medical science, prosthesis, etc., can solve the problem of inability to assess the safety of degradation and metabolism, and achieve the effect of increasing strength, promoting response, and improving sustainability

Active Publication Date: 2018-01-16
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these studies only used the self-healing function of dynamic gel, and ignored its special shock-absorbing and energy-absorbing effect; and the introduced special functional groups, although they can improve the properties of materials, have no way to really enter the market because Its catabolic safety cannot be assessed

Method used

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  • Injectable gel material for spinal repair

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] An injectable gel material for spinal repair, characterized in that: the preparation method of the gel material follows the steps:

[0026] Step 1, adding single-arm PEG into deionized water, stirring evenly, adding barium sulfate dispersant to prepare PEG aqueous solution;

[0027] Step 2, the HAuCl 4 Add deionized water to prepare gold-containing aqueous solution;

[0028] Step 3: Slowly add the gold-containing aqueous solution into the PEG aqueous solution, and stir well to obtain a dynamic hydrogel solution, which is the gel material.

[0029] The one-arm PEG in the step 1 adopts thiol-terminated 4-arm poly(ethylene glycol).

[0030] The molecular weight of the one-arm PEG in the step 1 is 2000.

[0031] The concentration of PEG in the step 1 is 25%.

[0032] The content of the barium sulfate in the said step 1 is 15%.

[0033] HAuCl of the gold-containing aqueous solution in the step 2 4 The concentration is 0.2M.

[0034] The volume ratio of the PEG aqueous...

Embodiment 2

[0036] An injectable gel material for spinal repair, characterized in that: the preparation method of the gel material follows the steps:

[0037] Step 1, adding single-arm PEG into deionized water, stirring evenly, adding barium sulfate dispersant to prepare PEG aqueous solution;

[0038] Step 2, the HAuCl 4 Add deionized water to prepare gold-containing aqueous solution;

[0039] Step 3: Slowly add the gold-containing aqueous solution into the PEG aqueous solution, and stir well to obtain a dynamic hydrogel solution, which is the gel material.

[0040] The one-arm PEG in the step 1 adopts thiol-terminated 4-arm poly(ethylene glycol).

[0041] The molecular weight of the one-arm PEG in the step 1 is 3000.

[0042] The concentration of PEG in the step 1 is 40%.

[0043] The content of barium sulfate in the described step 1 is 25%.

[0044] HAuCl of the gold-containing aqueous solution in the step 2 4 The concentration is 0.3M.

[0045] The volume ratio of the PEG aqueou...

Embodiment 3

[0047] An injectable gel material for spinal repair, characterized in that: the preparation method of the gel material follows the steps:

[0048] Step 1, adding single-arm PEG into deionized water, stirring evenly, adding barium sulfate dispersant to prepare PEG aqueous solution;

[0049] Step 2, the HAuCl 4 Add deionized water to prepare gold-containing aqueous solution;

[0050] Step 3: Slowly add the gold-containing aqueous solution into the PEG aqueous solution, and stir well to obtain a dynamic hydrogel solution, which is the gel material.

[0051] The one-arm PEG in the step 1 adopts thiol-terminated 4-arm poly(ethylene glycol).

[0052] The molecular weight of the one-arm PEG in the step 1 is 2500.

[0053] The concentration of PEG in the step 1 is 30%.

[0054] The content of barium sulfate in the described step 1 is 20%.

[0055] HAuCl of the gold-containing aqueous solution in the step 2 4 The concentration is 0.25M.

[0056] The volume ratio of the PEG aqueo...

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Abstract

The invention belongs to the field of biological materials, and particularly relates to an injectable gel material for spinal repair. Single-arm PEG is dissolved in deionized water, and barium sulfateis added and dispersed to obtain a PEG aqueous solution; HAuCl4 is added into the deionized water to prepare a gold-containing aqueous solution; finally the PEG aqueous solution and the gold-containing aqueous solution are mixed according to a ratio to obtain dynamic hydrogel. Based on the dynamic covalent chemical reaction method and by utilizing the conventional and safe raw materials, the dynamic gel with acceptable strength and biological compatibility is prepared.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to an injectable gel material for spinal repair, in particular to a PEG hydrogel material prepared by dynamic covalent chemical reaction. Background technique [0002] Lumbar degeneration refers to a joint lesion in which articular cartilage degenerates, followed by proliferative new formation of joint margins and subchondral bone. Labor, exercise or bad living habits lead to an increasing number of patients who need to repair the degenerated position of the lumbar intervertebral disc in the spine. It is conservatively estimated that more than 85% of the population will experience mild back pain, and 40% of these patients show lumbar degenerative disease. Change. Disc repair or reconstruction alone costs more than $200 billion a year in the United States, ranging from steroids to physical therapy to invasive foraminotomy or fusion. Surgical treatment of lumbar degen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/02A61L27/50A61L27/52
Inventor 孟庆怡许杉杉赵亮亮黄健翔
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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