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Thrombolytic effect of akebiasaponin D and application thereof

A kind of Mutong saponin and thrombolytic technology, which is applied in the application field of Mutong saponin D in the preparation of antithrombotic and thrombolytic drugs, and achieves the effect of significant application prospect.

Active Publication Date: 2018-01-16
杨中林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although antithrombotic and thrombolytic drugs have achieved remarkable results in the treatment of thrombosis, there is still a certain distance from ideal antithrombotic and thrombolytic drugs.

Method used

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  • Thrombolytic effect of akebiasaponin D and application thereof
  • Thrombolytic effect of akebiasaponin D and application thereof
  • Thrombolytic effect of akebiasaponin D and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1A

[0015] EXAMPLE 1 Experimental Study on the Anti-pulmonary Thrombosis Effect of ASD Injection in Mice

[0016] 1. Experimental purpose: To explore the anti-pulmonary thrombosis effect of ASD injection in mice.

[0017] 2. Experimental materials

[0018] 2.1 Pharmaceutical materials:

[0019] ASD (self-made, refer to the patent of inventor Yang Zhonglin for the preparation method, the patent number is ZL201210454454.7, and the patent name is a method for enriching and purifying aketoside D, with a purity of 97%), salvianolic acid salt for injection ( Shanghai Green Valley Pharmaceutical Co., Ltd., batch number: 20150247), urokinase for injection (Livzon Pharmaceutical Factory of Livzon Group, batch number:

[0020] 170207), collagen (Sigma, batch number: c7661), epinephrine (Shanghai Hefeng Pharmaceutical Co., Ltd., batch number:

[0021] 10160606), normal saline, distilled water, alcohol cotton, 1ml syringe, etc.

[0022] 2.2 Animals: 156 clean-grade Kunming mice (half male...

Embodiment 2

[0047] 1. Experimental purpose: To study the effect of different dosages of ASD injection on the thrombosis of arteriovenous bypass in rats.

[0048] 2. Experimental materials

[0049] 2.1 Reagents and drugs:

[0050] ASD (self-made, purity 97%), salvianolate for injection (Shanghai Green Valley Pharmaceutical Co., Ltd., batch number: 20150247), aspirin (Shanghai Aladdin Biochemical Technology Co., Ltd., c1720014), chloral hydrate (Sinopharm Group Chemical Co., Ltd. Reagent Co., Ltd., batch number: 20170421), normal saline, distilled water, polyethylene tube, oven, No. 4 surgical silk thread, syringe, etc.

[0051] 2.2 Animals: SD rats (half male and half female, weighing 250-300 grams).

[0052] 3. Experimental method

[0053] 3.1 Preparation of reagents and liquid medicine

[0054]3.1.1 Preparation of normal saline

[0055] Weigh 0.9g of sodium chloride, place it in a 100mL volumetric flask, add pure water to dissolve, and dilute to 100mL to obtain the product.

[0056...

Embodiment 3

[0081] The preparation of embodiment 3 ASD water injection

[0082] According to conventional methods, ASD is prepared into sterile, non-pyrogenic, clear and free of debris, isotonic, pH equal or similar to blood, safe (non-hemolytic, non-sensitizing) and stable water injections of different specifications.

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Abstract

The invention discloses thrombolytic effect of akebiasaponin D and the application thereof. The discovery of the thrombolytic activity of akebiasaponin D has innovativeness. Through anti-mouse pulmonary embolism and anti-rat carotid thrombus formation assay, SAD in vivo thrombolytic activity is researched. The thrombolytic effect has an obvious application prospect in the treatment of thrombotic diseases.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of aketoside D in the preparation of antithrombotic and thrombolytic drugs. Background technique [0002] Thrombotic disease is a group of circulatory system diseases that seriously endanger human health. It is characterized by blocking local blood flow after thrombus formation or falling off into an embolus to block downstream blood flow, resulting in ischemia and necrosis of organ tissues. There are many kinds of thrombotic diseases, including myocardial infarction (AMI), cerebral embolism (CE), pulmonary embolism (PE), deep vein thrombosis (DVT) and peripheral vascular embolism (VIE). There are causes such as damaged blood vessels, blood changes, and blood stasis. It is a disease that seriously endangers human health and life, and its morbidity, disability and mortality are all high. According to the statistics of the World H...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P7/02A61P9/10
Inventor 杨中林
Owner 杨中林
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