Micro-nano bioactive glass microsphere with surface nanometer pore structure and preparation method thereof

Abstract

The invention discloses a micro-nano bioactive glass microsphere with a surface nanometer pore structure and a preparation method thereof. The method comprises the following steps of (1) mixing water, ethanol and calcium nitrate tetrahydrate into a water phase solution; mixing tetraethoxysilane and cyclohexane into an oil phase solution; (2) mixing the water phase solution and the oil phase solution; then, sequentially adding surfactants, catalysts and triethyl phosphate; performing uniform stirring to obtain a bioactive glass gel solution; (3) performing centrifugal separation on the bioactive glass gel solution; performing cleaning to obtain wet state gel precipitates; then, performing drying to obtain the bioactive glass gel powder; (4) performing heat treatment on the obtained bioactive glass gel powder to obtain the micro-nano bioactive glass microsphere with the surface nanometer pore structure. The micro-nano bioactive glass microsphere has the advantages of good dispersivity and high specific surface area, can be used for loading medicine, bioactive molecules and the like, and belongs to an ideal micro-nano bone restoration carrier microsphere.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a micro-nano bioactive glass microsphere with a surface nano-pore structure and a preparation method thereof. Background technique [0002] Bioactive glass has excellent osteoinductive and bone repair effects, and is an important class of bioactive materials. So far, the bioactive glass used clinically for hard tissue repair is made by high-temperature melting method, but the bioactive glass prepared by high-temperature melting method has many shortcomings: high preparation conditions, high energy consumption; the prepared bioglass is dense particles, The specific surface area is small, and the effect of ion release and in vivo degradation is not good; the composition and particle size of the prepared bioglass are not easy to control and impurities are easily introduced during the preparation process. [0003] The sol-gel method is a commonly used method for the s...

AI Technical Summary

Problems solved by technology

So far, the bioactive glass used clinically for hard tissue repair is made by high-temperature melting method, but the bioactive glass prepared by high-temperature melting method has many shortcomings: high preparation conditions, high energy consumption; the prepared bioglass is dense particles, The specific surface area is small, the effect of ion release and in vivo degradation is not good; the composition and particle size of the prepared bioglass are not easy to control and impurities are easily introduced during the preparation process

In recent years, micro-nano bioactive glass has received extensive attention as a carrier, but the existing micro-nano bioactive glass has a serious agglomeration and poor dispersion, and its surface is relatively smooth and flat, and its adsorption force to drugs and bioactive molecules is small. It affects its performance as a carrier and limits its application

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