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Preparation method of organic silicon modified collagen membrane

A technology of organosilicon and collagen film, which is applied in the field of collagen film modification and preparation, can solve the problems of large cell toxicity and inability to use edible collagen packaging film, etc., and achieve the goal of improving hydrophobicity, maintaining collagen invariance, and excellent biological properties Effect

Active Publication Date: 2017-12-26
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although glutaraldehyde can improve the hydrophobicity very well, a large number of studies have confirmed that glutaraldehyde has greater cytotoxicity, and the collagen film modified with it cannot be used as an edible collagen packaging film

Method used

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  • Preparation method of organic silicon modified collagen membrane
  • Preparation method of organic silicon modified collagen membrane
  • Preparation method of organic silicon modified collagen membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Stir fish skin collagen with acetic acid solution with a concentration of 0.1mol / L in a water bath at 0°C until completely dissolved, and prepare a 5g / L collagen solution, remove air bubbles, cast into a film, and dry to obtain white transparent collagen Membrane; 1 part of the prepared collagen film was first placed in 20 parts of NaOH solution with a pH of 10.0 at 15°C, and then 5.52% of 3-(2,3-epoxypropoxy)propane was added by weight of the collagen film Trimethoxysilane (KH-560), shaken and reacted for 3 minutes; after the reaction, the collagen film was taken out, the surface was washed with water, and dried to obtain a modified collagen film.

[0034] The surface contact angle of the obtained collagen film was 93.5°, and the water absorption rate of the film was 142.56%.

Embodiment 2

[0036] Stir cowhide collagen with an acetic acid solution with a concentration of 0.3mol / L in a water bath at 2°C until it is completely dissolved, and prepare a 10g / L collagen solution, remove air bubbles, cast it into a film, and dry it to obtain a white transparent collagen film ; Place 2 parts of the prepared collagen film at 10°C in 40 parts of NaOH solution with a pH of 10.5, then add 6.35% 3-(2,3-epoxypropoxy)propyl by weight of the collagen film Methyldiethoxysilane (KH-1873), shaking reaction for 3 minutes; after the reaction, take out the collagen film, rinse the surface with water, and dry to obtain a modified collagen film.

[0037] The surface contact angle of the obtained collagen film was 101.6°, and the water absorption rate of the film was 138.97%.

Embodiment 3

[0039] Stir pigskin collagen with acetic acid solution with a concentration of 0.7mol / L in a water bath at 5°C until it is completely dissolved, and prepare a 7g / L collagen solution, remove air bubbles, cast it into a film, and dry to obtain white transparent collagen Membrane; 3 parts of the prepared collagen membrane were first placed in 60 parts of NaOH solution with a pH of 10.0 at 5°C, and then 5.76% of 2-(3,4-epoxycyclohexyl)ethane was added by weight of the collagen membrane Trimethoxysilane (A-186), shaken and reacted for 4 minutes; after the reaction, the collagen film was taken out, the surface was washed with water, and dried to obtain a modified collagen film.

[0040] The surface contact angle of the obtained collagen film was 97.9°, and the water absorption rate of the film was 145.68%.

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Abstract

The invention discloses a preparation method of an organic silicon modified collagen membrane. The method comprises the steps: firstly, completely dissolving animal collagen by using an acetic acid solutionto be prepared into a collagen solution; after removing bubbles, carrying out flow casting to form a membrane, and drying the membrane to obtain a white transparent collagen membrane; and then, placing the prepared collagen membrane into an inorganic alkaline solution, adding organic silicon, and carrying out a reaction at normal temperature, and after ending the reaction, washing the surface, and drying the collagen membrane to obtain a modified collagen membrane. The method is simple, convenient, very short in time consumption, low in equipment requirement and capable of shortening the preparation period and reducing the production cost; in addition, the hydrophobicity of the collagen membrane is greatly improved, an obstacle that the collagen membrane is applied to the commerce is basically eliminated, and the phenomenon that an exogenous toxic chemical substance enters the collagen membrane to affect the edibility of the collagen membrane is avoided.

Description

technical field [0001] The invention belongs to the technical field of collagen film modification and preparation, and in particular relates to a preparation method of organosilicon modified collagen film. Background technique [0002] Collagen is one of the main components of the extracellular matrix. It mainly exists in skin, bone, cartilage, blood vessels, teeth and tendons in animals, accounting for 25-33% of the total protein content of human or other animals. As a natural biomass resource, collagen has a triple helical structure, which makes collagen have low immunogenicity, biocompatibility, biodegradability and hemostatic repair function, and it is used in food industry, clinical medicine, cosmetics and other fields The importance and economic status of the country has become increasingly prominent. [0003] Collagen extracted with pepsin at low temperature, such as Zhou Wenchang et al. (Zhou Wenchang but Weihua Liao Longli, Lin Hai, Chen Chi, Qu Jianjian, Ye Yichun...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08J7/16C08J5/18C08L89/00
CPCC08J5/18C08J7/12C08J7/16C08J2389/00
Inventor 李国英李进财张元智刘文涛
Owner SICHUAN UNIV
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