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Activation device with nanowire fiber array applied to nerve cell local ion channel

A nanofiber array and nerve cell technology, which is applied in the field of activation devices for local ion channels of nerve cells, can solve the problems of cumbersome operation steps and the inability to operate multiple cells at the same time, and achieve the effect of improving activity

Inactive Publication Date: 2017-12-26
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even if a nanofiber transmission laser with a relatively small optical area is used to locally irradiate the cell body or axon, since it needs to use a micro-manipulation table or a micro-manipulation instrument to move the light source at a fixed point, it can only irradiate a single cell, not only the operation steps It is cumbersome and cannot operate on multiple cells at the same time

Method used

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  • Activation device with nanowire fiber array applied to nerve cell local ion channel
  • Activation device with nanowire fiber array applied to nerve cell local ion channel
  • Activation device with nanowire fiber array applied to nerve cell local ion channel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The nerve cells are cultured on the surface of the nanofiber array 2, and the nerve cells are randomly spread on the nanofiber array.

[0033] The contact interface between cells and nanofibers will have the following three situations:

[0034]In the first type, only the cell body 10 falls on the nanofiber array 2, and the axon 20 does not fall on the nanofiber array 2;

[0035] Second, only the axons 20 land on the nanofiber array 2,

[0036] The cell body 10 does not land on the nanofiber array 2;

[0037] In the third type, the axon 20 and the cell body 10 fall on the nanofiber array 2 at the same time.

Embodiment 2

[0039] Examine nerve cell illumination using a light source illuminated from the bottom of the nanofiber array substrate:

[0040] For the first case of the first embodiment above, the light only falls on the cell body 10 and does not shine on the axon 20;

[0041] For the second case of the above-mentioned embodiment 1, the light only falls on the axon and does not irradiate the cell body;

[0042] For the third case of the first embodiment above, the light falls on the axon and the cell body at the same time.

Embodiment 3

[0044] Examining the irradiation of ion channels on the cell bodies and axons of nerve cells,

[0045] For the first case of the first embodiment above, the ion channel on the cell body 10 is directly irradiated by light, while the ion channel on the axon 20 is not directly irradiated by light;

[0046] For the second case of the first embodiment above, the ion channel on the axon 20 is directly irradiated by light, while the ion channel on the cell body 10 is not directly irradiated by light;

[0047] For the third case of the first embodiment above, the ion channels on the cell body 10 and the axon 20 are directly irradiated by light.

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Abstract

The invention belongs to the technical field of nerve cell activation products, and particularly discloses an activation device with a nanowire fiber array applied to a nerve cell local ion channel, which comprises a nano fiber array substrate, a nano fiber array placed on the nano fiber substrate and an illumination light source illuminating the back surface of the nano fiber substrate. Due to the activation device, illumination on cell bodies or axons of the nerve cells can be realized locally, activation or structure change is carried out on the ion channel on the surface of the cell bodies or the axons of the nerve cells, the activation of the ion channel can be adjusted significantly, abnormal mental activities are improved effectively, and mental illnesses are treated.

Description

technical field [0001] The invention belongs to the technical field of nerve cell activation, and in particular relates to an activation device for applying a nanowire fiber array to local ion channels of nerve cells. Background technique [0002] In the field of biomedical research, it is of great research and application significance to apply spatially regional or time-resolved external stimuli (such as light, electricity, magnetism, etc.) to biological cells. For example, drawing on the analog bioelectric phenomenon, using electricity to stimulate neurons to promote the repair of their peripheral nervous system. [0003] As we all know, the bioelectricity of the human body plays a vital role in various biological functions such as maintaining signal transmission in the nervous system, controlling muscle contraction, and accelerating wound healing. Applying electrical stimulation has the advantage of being relatively easy to implement ex vivo in two or three dimensions, a...

Claims

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Application Information

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IPC IPC(8): A61N5/06
CPCA61N5/0601A61N5/0622A61N2005/0612A61N2005/063
Inventor 谢曦杭天陈惠琄何根柳成林潘烁琳杨成端张爱华
Owner SUN YAT SEN UNIV
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