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Method for treating progeria or Hutchinson-Gilford progeria syndrome

A progeria, therapeutic agent technology, applied in the field of cell therapy, can solve problems such as progeria without treatment

Active Publication Date: 2017-12-01
BOYALIFE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Regrettably, so far there is no clinically effective treatment for progeria

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Example 1: Treatment with placental mesenchymal stem cells, namely GD2+ stromal cells and umbilical cord blood KDR+ hematopoietic stem cells aging mice

[0092] 1. Selection and grouping of animals

[0093] 1. Selection of animals: Model mice are healthy C57BL / 6J mice, female, 8 weeks old, weighing 18-22 g, 60 mice.

[0094] 2. Grouping of animals: Simply randomly divide them into three groups: control group, model group and treatment group, with 20 animals in each group.

[0095] 2. Establishment of mouse aging model

[0096] The model group and the treatment group were subcutaneously injected with 5% D-galactose on the back of the neck every day, the injection volume was 0.25ml / 10g, and the aging animal model was established by continuous administration for 8-16 weeks. The control group was given the same volume of normal saline.

[0097] 3. Infusion

[0098] Two weeks after the aging model was established, the treatment group was injected with GD2+ placental M...

Embodiment 2

[0114] Example 2: Treatment with placental mesenchymal stem cells, namely GD2+ stromal cells and umbilical cord blood KDR+ hematopoietic stem cells aging mice

[0115] In Example 2 and its supplementary tests, if not otherwise stated, glycine and mannitol were added to the mesenchymal stem cell suspension used.

[0116] 1. Selection and grouping of animals

[0117] 1. Selection of animals: Model mice are healthy C57BL / 6J mice, female, 8 weeks old, weighing 18-22 g, 60 mice.

[0118] 2. Grouping of animals: Simply randomly divide them into three groups: control group, model group and treatment group, with 20 animals in each group.

[0119] 2. Establishment of mouse aging model

[0120] The model group and the treatment group were subcutaneously injected with 5% D-galactose on the back of the neck every day, the injection volume was 0.25ml / 10g, and the aging animal model was established by continuous administration for 8-16 weeks. The control group was given the same volu...

Embodiment 3

[0140] Example 3: Mechanism research on MSC+HSC treatment of aging mice

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PUM

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Abstract

The invention belongs to the technical field of cell treating, relates to a method for treating progeria or Hutchinson-Gilford progeria syndrome, in particular to a treating agent for restoring body function aging and delaying recession of organ functions and comprising GD2+ stroma cells and KDR+ hematopoietic stem cells and further relates to application, in preparation of the treating agent for treating progeria or Hutchinson-Gilford progeria syndrome or for restoring body function aging and delaying recession of the organ functions, of the combination of the GD2+ stroma cells and the KDR+ hematopoietic stem cells. It has been found that the treating agent can be effectively used for treating progeria or Hutchinson-Gilford progeria syndrome, especially for restoring body function aging and delaying recession of the organ functions.

Description

technical field [0001] The invention belongs to the technical field of cell therapy, and relates to a method for treating progeria or progeria, in particular to a therapeutic agent for repairing the aging of body functions and delaying the decline of organ functions, in particular to a method comprising GD2+ stromal cells and therapeutic agents for KDR+ hematopoietic stem cells. Further, the present invention relates to the use of the combination of GD2+ stromal cells and KDR+ hematopoietic stem cells in the preparation of therapeutic agents for treating progeria or progeria or for repairing aging of body functions and delaying organ function decline. It has been found that the therapeutic agent of the present invention can be effectively used for the treatment of progeria or progeria, especially for repairing the aging of body functions and delaying the decline of organ functions. Background technique [0002] Aging can be divided into physiological aging and pathological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61K47/18A61K47/26A61P39/06
Inventor 许晓椿肖海蓉刘冰程霞周丹
Owner BOYALIFE
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