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Application of an anthraquinone compound in the preparation of antifungal drugs and antifungal composition

A technology of antifungal drugs and compounds, applied in the field of medicine, can solve problems such as toxic and side effects limiting clinical application, and achieve the effects of saving medical expenses, reducing drug dosage, and reducing toxic and side effects

Active Publication Date: 2019-11-12
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few drugs available for clinical treatment of deep fungal infections, and the toxic and side effects (such as nephrotoxicity of amphotericin, liver toxicity of azoles, etc.) have greatly limited clinical application. In addition, antifungal drugs are widely used The resulting increasingly serious drug resistance has made deep fungal infections a clinically difficult problem

Method used

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  • Application of an anthraquinone compound in the preparation of antifungal drugs and antifungal composition
  • Application of an anthraquinone compound in the preparation of antifungal drugs and antifungal composition
  • Application of an anthraquinone compound in the preparation of antifungal drugs and antifungal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1. Effect of compound 1 on different clinical fungal strains

[0027] Materials and methods

[0028] 1. Test drug:

[0029] Compound 1: from the internal compound database of the laboratory.

[0030] Fluconazole: Sigma Company, lot number 460M4707V.

[0031] Dimethyl sulfoxide: Shanghai Shiyi Biotechnology Co., Ltd.

[0032] All reagents were stored at -20°C. Before the experiment, the drug was taken out and placed in a 35°C incubator to melt, mixed well, and pharmacodynamic tests were carried out respectively.

[0033] 2. Strains:

[0034] Clinical strains: 1) Candida albicans, 2 strains; 2) Candida parapsilosis, 1 strain; 3) Candida glabrata, 1 strain; 4) Cryptococcus neoformans, 1 strain, 5) Aspergillus fumigatus, 1 strain, 6 ) Trichophyton rubrum, 1 strain, 7) Microsporum gypsumoid, 1 strain. The strains were provided by the Fungi Department of Shanghai Changhai Hospital, collected from clinical samples from different departments of Changhai Hospital,...

Embodiment 2

[0068] Example 2. Effects of compound 1 combined with fluconazole on different clinical fungal strains

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Abstract

The invention provides an application of anthraquinone compound in preparing an antifungal drug and an antifungal composition, which belongs to the technical field of medicine. The anthraquinone compound is 9,10-dioxo-N-(5-phenylthiazole-2-groupyl)-9,10-dihydroanthracene-2-sulfonyl; and an in vitro cell experiment proves that the anthraquinone compound has good antifungal effect for various clinical fungi strains, the application dosage of the antifungal drug can be obviously reduced, the inhibition effect for the drug-resistant fungi can be improved, and the effect of the antifungal drug for the drug-resistant fungi can be restored.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of an anthraquinone compound in the preparation of antifungal drugs and an antifungal composition. Background technique [0002] In recent years, due to the wide clinical application of immunosuppressants, broad-spectrum antibiotics, tumor chemotherapy drugs and hormone drugs, the incidence of AIDS and diabetes has been increasing, the number of immunocompromised patients has been increasing, and the rate of deep fungal infection has risen sharply. Deep fungal infection, as a comorbidity, has become the main cause of death in the above-mentioned immunocompromised patients. At present, there are few drugs available for clinical treatment of deep fungal infections, and the side effects (such as nephrotoxicity of amphotericin, hepatotoxicity of azoles, etc.) have greatly limited clinical application. In addition, antifungal drugs are widely used The inc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/426A61K31/4196A61P31/10
CPCA61K31/4196A61K31/426A61K2300/00
Inventor 刘伟
Owner SHAANXI UNIV OF SCI & TECH
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