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A kind of preparation method of the antibacterial NCC film of surface grafting sulfonamide drug group

A technology of sulfonamide drugs and films, which is applied in the field of preparation of antibacterial NCC films, can solve problems such as no antibacterial effect, and achieve the effects of achieving antibacterial performance, good antibacterial performance and controllable size.

Active Publication Date: 2020-10-27
SUZHOU HONGJIU AVIATION THERMAL MATERIALS TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the traditional NCC film does not have antibacterial effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A kind of preparation method of the antibacterial NCC film of surface grafting sulfonamide drug group, comprises the following steps:

[0021] (1) Dispersing the negatively charged nanocellulose on the surface in deionized water, ultrasonication for 10nin, and standing still to obtain a NCC dispersion with a concentration of 0.01%;

[0022] (2) adjusting the pH value of the NCC dispersion obtained in step (1) with a 20% NaOH solution, so that the pH value is 7.5-9.0;

[0023] (3) Add sulfamethazine aqueous solution with a concentration of 0.8g / L to the solution obtained in step (2), rapidly raise the temperature to 80°C, react with ultrasonic stirring for 40min, then cool down to 35°C and discharge the material, and control the heating process rate at 2°C / min, keep the pH value in the range of 7.5-9.0;

[0024] (4) The product solution obtained in step (3) was prepared by a filtration method to obtain an antibacterial NCC film grafted with sulfonamide drug groups on t...

Embodiment 2

[0027] A kind of preparation method of the antibacterial NCC film of surface grafting sulfonamide drug group, comprises the following steps:

[0028] (1) Disperse the negatively charged nanocellulose on the surface in deionized water, after ultrasonication for 100min, let stand to obtain a NCC dispersion with a concentration of 0.2%;

[0029] (2) adjusting the pH value of the NCC dispersion obtained in step (1) with a NaOH solution with a concentration of 30%, so that the pH value is 7.5-9.0;

[0030] (3) Add 1.2g / L sulfisoxazole aqueous solution to the solution obtained in step (2), rapidly raise the temperature to 95°C, react with ultrasonic stirring for 60 minutes, then cool down to 50°C and discharge, and control the heating process rate at 4°C / min , keep the pH value in the range of 7.5-9.0;

[0031] (4) The product solution obtained in step (3) was prepared by a filtration method to obtain an antibacterial NCC film grafted with sulfonamide drug groups on the surface.

...

Embodiment 3

[0034] (1) Disperse the negatively charged nanocellulose on the surface in deionized water, after ultrasonication for 50min, let stand to obtain a NCC dispersion with a concentration of 0.1%;

[0035] (2) adjusting the pH value of the NCC dispersion obtained in step (1) with a NaOH solution with a concentration of 25%, so that the pH value is 7.5-9.0;

[0036] (3) Add a sulfamethazine aqueous solution with a concentration of 1.0 g / L to the solution obtained in step (2), rapidly raise the temperature to 90°C, react with ultrasonic stirring for 50 minutes, then cool down to 40°C and discharge, and control the heating process rate at 3°C / min, keep the pH value in the range of 7.5-9.0;

[0037] (4) The product solution obtained in step (3) was prepared by a filtration method to obtain an antibacterial NCC film grafted with sulfonamide drug groups on the surface.

[0038] The raw material for preparing the negatively charged nanocellulose on the surface is selected from cotton li...

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Abstract

The invention discloses a preparation method of an antibacterial NCC (nano-crystalline cellulose) film with sulfonamide medicine groups grafted on the surface. The method comprises the following steps of (1) dispersing NCC with negative electricity on the surface into deionized water to obtain an NCC dispersion liquid; (2) using an NaOH solution for regulating the pH value of the NCC dispersion liquid to be 7.5 to 9.0; (3) adding a sulfonamide medicine solution into the obtained solution; fast raising the temperature to 80 to 95 DEG C; performing ultrasonic agitation reaction; lowering the temperature; performing discharging; (4) preparing the antibacterial NCC film with sulfonamide medicine groups grafted on the surface from the product solution obtained in the step (3) by using a filtering method. Amino groups of sulfonamide medicine are used for being combined with hydroxyls of the NCC; the NCC film with the antibacterial performance is obtained; through the addition of the sulfonamide, the antibacterial performance of the NCC film is improved; the storage conditions are expanded; the application range of the NCC film is expanded; meanwhile, the price of the raw materials is low; the resources are wide; the method is applicable to general production and popularization.

Description

technical field [0001] The invention belongs to the technical field of composite materials, in particular to a method for preparing an antibacterial NCC film whose surface is grafted with sulfonamide drug groups. Background technique [0002] Nanocellulose (NCC) is a fiber aggregate with a diameter of <100 nm and a length of up to microns. It has excellent mechanical properties, large specific surface area, high crystallinity, high hydrophilicity, high transparency, low density, good biodegradability, biocompatibility, and stable chemical properties. Therefore, nanocellulose has shown great application potential in the fields of biopharmaceuticals, food processing, papermaking, energy materials, and functional materials. [0003] NCC films have excellent mechanical properties, optical properties and barrier properties different from ordinary fiber films, which are inseparable from their structure. Macroscopically, NCC films are similar to ordinary plastics. However, it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08L1/02C08K5/435C08K5/47
CPCC08J5/18C08J2301/02C08K5/435C08K5/47C08L1/02
Inventor 陈照峰胡雅张俊雄沈胜叶信立
Owner SUZHOU HONGJIU AVIATION THERMAL MATERIALS TECH CO LTD
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