A column valve for continuous chromatographic separation and purification apparatus and its application method

Abstract

The invention discloses a column place valve for a continuous spectrum separation and purification instrument and a use method of the column place valve, and belongs to the technical field of chemical and pharmaceutical equipment. The column place valve comprises a valve plate base, a feeding pump, an elution pump and four chromatographic columns, wherein the valve plate base is composed of a long-side valve plate, a short-side valve plate, a top valve plate and a bottom valve plate; the feeding pump, the elution pump and the chromatographic columns are arranged on the outer side of the valve plate base; 26 two-position two-way electromagnetic valves of a same structure are arranged on the top valve plate of the valve plate base; the 26 two-position two-way electromagnetic valves form a front electromagnetic valve group, a middle electromagnetic valve group and a rear electromagnetic valve group; a connection flowing channel of the column place valve is arranged inside the valve plate base. The column place valve is novel and compact in structure and clear in method principle; due to adoption of a four-column system and a valve plate structure, and flowing pipelines inside the valve plates, samples can be fed without interruption, the batch treatment time is shortened, the utilization rate of packing is high, sample outgoing can be effectively avoided, the size of packing is reduced, and the batch treatment time and the production time can be shortened.

Description

technical field [0001] The invention belongs to the technical field of chemical industry and biopharmaceutical equipment, and relates to a chromatographic separation device and its use method, in particular to a column position valve for a continuous chromatographic separation purifier and its use method. Background technique [0002] my country has the largest research team on the chemical components of traditional Chinese medicine and the structure of natural medicines, mainly engaged in the extraction, separation and structural identification of natural products. The large-scale and economical purification of proteins has gradually become an important issue in the biotechnology and pharmaceutical industries. Almost 80 More than 100% of the work is in the separation of natural compounds. This research field seems to be a labor-intensive manual labor. The separation and purification of natural compounds has become a bottleneck in the creation of natural medicines or the disco...

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Problems solved by technology

[0004] The purpose of the present invention is to solve the above-mentioned disadvantages of the existing continuous chromatographic separation and purification equipment with complex structure, high production cost, long separation time for complex compound mixed systems, large packing volume, low utilization efficiency of packing, and ineffective improvement of production efficiency. , a column valve for continuous chromatographic separation and purification apparatus and its use method are proposed. The valve plate structure can effectively prevent the sample from passing through, so that it can improve the packing utilization efficiency, save the packing volume, save batch processing time and Shorter production times are beneficial

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