CaCO3-(PLO/Fucoidan)<4> self-assembly carriers and preparation method

Abstract

The invention discloses CaCO3-(PLO / Fucoidan)<4> self-assembly carriers and a preparation method. CaCO3 microspheres with good biocompatibility are prepared through a coprecipitation method firstly, and growth of the CaCO3 microspheres is controlled by utilizing carboxymethyl chitosan; and polyelectrolytes of PLO and Fucoidan are assembled on the surfaces of the CaCO3 microspheres layer by layer, wherein the polyelectrolytes have nutrient and pharmacological efficacies and are degradable, and thus LbL microspheres, namely the CaCO3-(PLO / Fucoidan)<4> self-assembly carriers, are prepared. According to the preparation method, the coprecipitation method and an LbL technique are combined, the technology is simple, operation is convenient, a complex instrument and equipment are not needed, and the problems of poor biocompatibility of carriers, initial burst release in drug release and the like are solved. The LbL microspheres are of core-shell type structures, can enhance the adsorbing capacity of a drug, reduces the toxic and side effects caused by pure use of the drug and can obviously slow down the release rate of the drug.

Description

technical field [0001] The present invention relates to a calcium carbonate-(polyornithine / fucoidan) 4 Self-assembling carrier and its preparation method. Background technique [0002] With the in-depth study of drug carrier systems and the continuous development of surface modification technology, surface-modified drug carrier systems have become the focus of research in recent years. In the treatment of diseases, the drug carrier entering the animal body may be unable to exert its effect due to the deposition of the adsorbed protein or the phagocytosis of the immune cells. Therefore, the stability of the drug carrier in the animal body is very important for the drug effect. Using surface modification technology Putting an "invisibility cloak" on the surface of the drug carrier can solve this problem to some extent. Therefore, the use of surface modification technology to protect the drug carrier system to achieve safe drug delivery and sustained release therapy can reduc...

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Problems solved by technology

[0004] Aiming at the problems of strong reaction, complex operation, no biological activity of modifiers and low drug loading of calcium carbonate microspheres faced by many surface modification technologies at present, the object of the present invention is to provide a calcium carbonate-(polybird) that delays the drug release rate. amino acid / fucoidan) 4 (i.e. CaCO 3 -(PLO / Fucoidan) 4 ) self-assembled carrier

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