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Application of red cabbage pigment in preparation of endoscope coloring agent

A dyeing agent and endoscopic technology, applied in the field of dyeing agents, can solve the problems of indigo carmine instability, loss of dyeing function, unclear effect, etc., and achieve good stability, clear texture and lesion boundaries, and strong anti-free radical effect Effect

Active Publication Date: 2017-11-21
BEIJING COMPONT MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these dyes are non-edible chemical preparations, which have unclear effects on the human body, especially the lesion tissue, and even have certain toxic or carcinogenic effects.
In addition, the most commonly used dyeing agent indigo carmine itself is unstable, and the indigo carmine solution will undergo oxidation reaction in the air, and it will gradually deteriorate and lose its dyeing function.

Method used

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  • Application of red cabbage pigment in preparation of endoscope coloring agent
  • Application of red cabbage pigment in preparation of endoscope coloring agent
  • Application of red cabbage pigment in preparation of endoscope coloring agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1, the preparation of the endoscope staining agent that comprises the different concentrations of red cabbage pigment

[0037] The citric acid-sodium citrate buffer used below was prepared according to the conventional citric acid-sodium citrate buffer formula using citric acid, sodium citrate and purified water; the disodium hydrogen phosphate-citrate buffer was also prepared using hydrogen phosphate Disodium, citric acid and purified water were prepared according to the conventional disodium hydrogen phosphate-citric acid buffer formula.

[0038] 1. Preparation of an endoscope staining agent with a red cabbage pigment concentration of 50 ppm:

[0039] 50 mg of red cabbage pigment was dissolved in 1 kg of pH6.2 citric acid-sodium citrate buffer to obtain an endoscope stain solution with a red cabbage pigment concentration of 50 ppm and a pH of 6.2.

[0040] 2. Preparation of an endoscope staining agent with a red cabbage pigment concentration of 0.1%:

[0...

Embodiment 2

[0050] Example 2, the use of endoscopic stains comprising red cabbage pigment

[0051] Put the endoscope stain solution into the flushing tube, send it into the body through the mouth or other natural channels, and spray it directly. After the endoscopic observation is completed, put water into the flushing tube to wash away the endoscope stain.

Embodiment 3

[0052] Embodiment 3, comparative test

[0053] 1. Experimental method

[0054] The colonic mucosa was subjected to common endoscopy, 0.3% indigo carmine dyeing+common endoscopy and 0.3% endoscope staining agent+common endoscopy in Example 1, 0.1% endoscope staining agent+common endoscopy in Example 1, NBI and 0.3% endoscopic staining agent+NBI in Example 1 were carried out directly, and the results are shown in Table 1.

[0055] Table 1 Technical scheme of the present invention and comparative technical scheme effect comparison result

[0056]

[0057] figure 1 It is an ordinary endoscopic photograph of the colonic mucosa without any staining, and the microstructure of the lesion (indicated by the thick white arrow) and surrounding mucosa (indicated by the thin black arrow) is not displayed.

[0058] figure 2 In order to observe the pictures of common endoscopic examination after staining the colonic mucosa with 0.3% indigo carmine, it can be seen that the indigo carmi...

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Abstract

The invention provides application of a red cabbage pigment in preparation of an endoscope coloring agent. When the endoscope coloring agent prepared by the red cabbage pigment is used, the definition of a mucosa in an endoscopy is enhanced, and the microstructure, texture and lesion boundary of the mucosa are all more distinct, so that a doctor can observe more conveniently; the application is especially suitable for the screening of early-stage cancer.

Description

technical field [0001] The invention relates to the field of staining agents, in particular to the application of red cabbage pigment in the preparation of endoscope staining agents. Background technique [0002] An endoscope is a tube equipped with a light that can enter the body through a natural orifice to observe lesions. Ordinary endoscopes use a xenon lamp as illumination light, which is also called "white light". The surface of normal tissue mucosa is smooth, and when there are lesions, such as ulcers, infections, cancers, etc., the surface will change, but some lesions, such as early cancer or flat lesions, are easy to be missed by ordinary endoscopic observation. [0003] Endoscopic narrow-band imaging (NBI) is an emerging endoscopic technology. The NBI system limits light of different wavelengths, leaving only red, green, and blue narrow-band light waves with wavelengths of 605nm, 540nm, and 415nm. The depth of penetration of the narrowband light wave into the gas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K49/006
Inventor 沈伟张建国
Owner BEIJING COMPONT MEDICAL DEVICES
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