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Preparation method of bionic carotid artery blood vessel

A carotid artery and blood vessel technology, which is applied in the direction of blood vessels, devices of human tubular structures, etc., to achieve the effect of ensuring molding accuracy

Inactive Publication Date: 2017-11-21
XI AN JIAOTONG UNIV
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Problems solved by technology

[0003] The combination of manufacturing technology and life science has realized the substantial transformation of biological tissue manufacturing from profiling to biomimetic, and laid the foundation for the preparation of biomimetic carotid vessels. Therefore, the construction of highly bionic carotid arteries is the key to current research

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  • Preparation method of bionic carotid artery blood vessel
  • Preparation method of bionic carotid artery blood vessel

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Embodiment Construction

[0026] The present invention will be described in detail below with reference to the accompanying drawings and embodiments, taking the construction of a gelatin hydrogel bionic carotid vessel as an example.

[0027] refer to figure 1 , a basic structural diagram of a bionic carotid artery. The bionic carotid artery structure is similar to the human carotid artery. It is divided from the common carotid artery to the internal carotid artery and the external carotid artery. Adhesion proliferation.

[0028] refer to figure 2 , a method for preparing a bionic carotid blood vessel, comprising the following steps:

[0029] 1) According to the statistics of the shape and size of the human carotid artery, the carotid artery structure with a circular cross-section is designed by computer-aided software. The circular carotid artery structure is composed of the common carotid artery, the carotid sinus, the internal carotid artery and the external carotid artery. Among them, the diamet...

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Abstract

The invention discloses a preparation method of a bionic carotid artery blood vessel. The preparation method comprises the following steps: firstly, preparing a resin mode and a resin minor of the bionic carotid artery blood vessel, filling the resin model and the resin minor with liquid-state silica gel, and implementing curing and demoulding so as to obtain a silicon rubber model and a silicon rubber minor of the bionic carotid artery blood vessel; assembling the silicon rubber model, pouring de-ionized water into the assembled silicon rubber model, and implementing ultra-low temperature freezing, so that a bionic carotid artery blood vessel ice model is formed; injecting a biological material water solution into the silicon rubber minor of the bionic carotid artery blood vessel, implementing cross-linking treatment to separate semigel and model minor, so as to obtain a semi-hydrogel formed bionic carotid artery semicircular part; assembling the bionic carotid artery ice model and the semi-hydrogel formed bionic carotid artery semicircular part, pouring the biological material water solution, so that the ice model is unfrozen, and implementing cross-linking on the biological material solution to obtain a hydrogel, so that a hydrogel bionic carotid artery blood vessel is obtained; and pouring a cell suspension into the hydrogel bionic carotid artery blood vessel so as to form a cell layer on the inner surface of the hydrogel bionic carotid artery blood vessel, so that the bionic carotid artery blood vessel is formed. The bionic carotid artery blood vessel provided by the invention is profile-modeling and bionic.

Description

technical field [0001] The invention relates to the technical field of bionic blood vessel preparation, in particular to a method for preparing bionic carotid blood vessels. Background technique [0002] Carotid artery disease is the main cause of cerebrovascular disease. The causes of carotid artery lesions include the influence of its structure on blood flow, as well as the dysfunction of cells in blood vessels. Therefore, the study of carotid artery lesions not only requires the construction of a structure similar to the human carotid artery, but also requires it to have certain Carotid artery function. Therefore, manufacturing a functional artificial carotid artery is a hot topic of research at home and abroad. [0003] The combination of manufacturing technology and life science has realized the substantial transformation of biological tissue manufacturing from profiling to biomimetic, and laid the foundation for the preparation of biomimetic carotid vessels. Therefo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06
CPCA61F2/06
Inventor 刘亚雄陈若梦王博林蓉贺健康李涤尘
Owner XI AN JIAOTONG UNIV
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