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Traditional Chinese medicine composition and application thereof for treating cancer pain

A cancer pain and composition technology, applied in the field of traditional Chinese medicine preparations, can solve the problems of dependence, many adverse reactions, addiction, etc., and achieve the effects of improving the symptoms of patients, significantly analgesic effect, and dilating local blood vessels

Active Publication Date: 2021-01-15
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of cancer pain mostly adopts WHO's three-step standardized treatment, and its curative effect is remarkable. Opioid-based analgesics can relieve ≥95% of pain patients, but there are many adverse reactions after long-term use, such as non-steroidal anti-inflammatory drugs Peptic ulcer bleeding, liver and kidney function damage, opioid nausea, vomiting, lethargy, respiratory depression, addiction, and dependence

Method used

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  • Traditional Chinese medicine composition and application thereof for treating cancer pain
  • Traditional Chinese medicine composition and application thereof for treating cancer pain
  • Traditional Chinese medicine composition and application thereof for treating cancer pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] This embodiment provides a kind of hot pack (such as figure 1 and figure 2 shown), the preparation method comprises the following steps:

[0046] (1) Grind 4 parts of Cyperus cyperi, 4 parts of Sanqi, 4 parts of Chuanxiong, 4 parts of Angelica, 2 parts of blood, 40 parts of clove, 15 parts of Evodia rutaecarpa, and 4 parts of catechin into a 2-4mm coarse powder, and 11 parts of coarse salt are mixed to obtain medicinal powder.

[0047] (2) The drug powder is packed into a 20cm*25cm single-layer pure cotton bag (referred to as the first cloth bag), sealed to obtain a traditional Chinese medicine bag.

[0048] (3) Pack the sealed traditional Chinese medicine into the outer layer constant temperature bag to get ready.

[0049] The preparation method of outer layer constant temperature bag comprises the following steps:

[0050] Make a 22cm*27cm pure cotton bag (denoted as the second cloth bag); a pocket is provided on the second cloth bag and a horizontal zipper is in...

Embodiment 2

[0057] The analgesic effect of embodiment 2 Weijianning to mouse acetic acid writhing

[0058] 1 Materials and methods

[0059] 1.1 Animals 40 NIH mice, weighing 18-20g, half male and half male, provided by Guangdong Provincial Medical Experimental Animal Center, the experimental animal production license number is SCXK (Guangdong) 2013-0002, and the experimental animal quality certificate number is №44007200032418; Animal experiment environment: SPF level animal laboratory of Guangdong Provincial Institute of Traditional Chinese Medicine, the facility use license number is SYXK (Guangdong) 2010-0059.

[0060] 1.2 Drugs and reagents

[0061] The traditional Chinese medicine composition (referred to as Weijianning in the present invention) for the treatment of cancer pain consists of the following components by weight: 4 parts of Rhizoma Cyperi, 4 parts of Panax notoginseng, 4 parts of Rhizoma Chuanxiong, 4 parts of Angelica sinensis, and 2 parts of blood jellyfish , 40 parts...

Embodiment 3

[0069] Example 3 Analgesic effect of Weijianning on mice with liver cancer

[0070] 1 Experimental method

[0071] Diethylnitrosamine-induced liver cancer model: mice (№44007200025543) were randomly divided into 4 groups (blank control group, model control group, and 2 administration groups). The mice were fed daily drinking water containing 30 μg·mL -1 DEN solution, mice in the blank control group were fed with sterile distilled water, and after 23 weeks of continuous modeling, they were used for analgesic experiments.

[0072] Remove hair from the belly of the model animal by 1*1cm 2 , placed in a hot plate apparatus at (55±0.5)°C, licking the hind paw as an index of pain response, recording the time required from putting the mouse in the hot plate apparatus to licking the hind paw, and measuring it again on the second day. The average value of 2 consecutive days was used as the basic pain threshold before administration, and the predicted mouse 5s

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Abstract

The present invention relates to a traditional Chinese medicine composition for treating cancer pain, and applications thereof, wherein the active components of the traditional Chinese medicine composition comprise, by weight, 2-15 parts of cyperus rotundus l, 2-15 parts of panax notoginseng, 2-15 parts of ligusticum chuanxiong hort, 2-15 parts of angelica sinensis, 1-5 parts of daemonorops draco bl, 30-45 parts of clove bud, 10-25 parts of tetradium ruticarpum, and 2-8 parts of catechu. According to the present invention, the traditional Chinese medicine composition has effects of spleen and stomach warming and nourishing, detoxifying, stasis removing, anticancer and pain stopping, can be used for treating patients with gastric precancerous lesion caused by intermingled deficiency and excess and intermingled cold and heat, can improve the symptoms (such as gastric distention, stomach pain and dyspeptic retention) of patients, can resist the tumor-induced nerve pain of nude mice bearing ASG gastric cancer transplanted tumors, and can provide significant analgesic effect for painful mice.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating cancer pain and its application. Background technique [0002] Cancer pain is one of the common symptoms of cancer patients. About 40% to 70% of cancer patients experience different degrees of cancer pain. The incidence of pain in patients with advanced cancer is as high as 90%, and nearly 40% of them are severe pain. Cancer pain not only affects patients' daily life, interpersonal communication and quality of life, but also leads to depression, anxiety, despair and many other adverse psychological states of patients, and even leads to interruption of treatment and suicide in severe cases. Accurate assessment of the degree of pain in cancer patients and timely and effective pain control have become one of the primary concerns of clinical care. [0003] At present, the treatment of cancer pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8905A61K36/896A61P35/00A61P29/00A61M37/00A61K33/14
CPCA61K9/0004A61K9/0014A61K33/14A61K36/232A61K36/236A61K36/258A61K36/48A61K36/61A61K36/754A61K36/889A61K36/8905A61K36/896A61M37/00A61K2300/00
Inventor 潘华峰赵自明史亚飞李思怡曾晓会严艳刘友章蔡甜甜陈晓东林钟宇赵金媛
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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