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Application of GW3965 for preparation of medicines preventing and treating kidney ischemia reperfusion injuries

A renal ischemia-reperfusion and drug technology, which can be used in drug combinations, medical preparations containing active ingredients, antipyretics, etc. Repair kidney function, improve kidney damage, targeted effects

Active Publication Date: 2017-11-10
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, because there is no clear drug to prevent kidney damage, the incidence of kidney damage cannot be controlled, which further aggravates the harm of kidney damage to human health.

Method used

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  • Application of GW3965 for preparation of medicines preventing and treating kidney ischemia reperfusion injuries
  • Application of GW3965 for preparation of medicines preventing and treating kidney ischemia reperfusion injuries
  • Application of GW3965 for preparation of medicines preventing and treating kidney ischemia reperfusion injuries

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Experimental program
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Embodiment 1

[0026] GW3965 is purchased from Selleckchem company among the embodiment one, what purchased is GW3965HCl, MolecularWeight (MW): 618.51, and structure is as follows:

[0027]

[0028] Example 1: Protective effect of GW3965 on renal ischemia-reperfusion (RI / R) injury in rats.

[0029] Thirty SD rats, weighing 220-280 g, were purchased from the Animal Experiment Center of Fourth Military Medical University. Rats were housed in separate cages (environmental temperature was 24° C., humidity was 60%-70%). Thirty rats were randomly divided into the following groups (n=6): sham operation group, model group, and GW3965 administration group (including high, medium, and low dose groups). They were fasted 6 hours before the operation and had free access to water. Rats in each group were anesthetized by intraperitoneal injection of 10% chloral hydrate, fixed on their backs, and then the GW3965 administration group was intraperitoneally injected with GW3965 aqueous solution. ), the sh...

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Abstract

The invention discloses an application of GW3965 for preparation of medicines preventing and treating kidney ischemia reperfusion injuries. The GW3965 is a selective LXR agonist, and acts on LXR[alpha] and LXR[beta]. Significant medicine effects of the GW3965 allow the GW3965 to have a potential for development into as a medicine preventing and treating kidney injuries, and allow the GW3965 to be a research direction of new medicines preventing and treating kidney injuries.

Description

technical field [0001] The invention belongs to the new application field of compounds, and specifically relates to the application of GW3965 in the preparation of drugs for preventing and treating renal ischemia-reperfusion injury. Background technique [0002] As an important organ of the human body, the kidney is responsible for maintaining the balance of water and salt metabolism in the body and the stability of the internal environment. The related diseases seriously threaten human health. Taking kidney injury disease as an example, the incidence rate of kidney disease in developed countries is 6.5%-10%, while the incidence rate in some parts of China is as high as 8%-12%. Since 2005, there have been about 60,000 uremia patients receiving renal replacement therapy in my country, with an annual growth rate of more than 11%, becoming a common clinical critical disease, and the fatality rate of acute kidney injury is as high as 30%. Therefore, it is of great significance ...

Claims

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Application Information

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IPC IPC(8): A61K31/195A61P13/12A61P29/00
CPCA61K31/195
Inventor 吴玉梅李玉娇孙婷李彦娇杨乐郭艳艳魏新苗招明高
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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