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Icodextrin biomaterial and preparation method thereof

A technology of icodextrin and biomaterials, which is applied in the direction of drug combination, medical formula, surgical drugs, etc., can solve the problems of inability to inhibit implantation transfer, difficulty in preventing infection, ineffective antibacterial, and hemostasis, and achieve the promotion of epithelial The growth of cells and vascular endothelial cells, the reduction of skin irritation, and the effect of saving the amount of medication

Inactive Publication Date: 2017-11-03
JIANGSU HAIERZI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Currently, normal saline is traditionally used as the flushing solution used in clinical practice. Conventional normal saline can neither effectively antibacterial, stop bleeding, prevent tissue adhesion, and promote wound healing, nor can it inhibit implantation metastasis due to adhesion of scattered tumor cells during surgery.
For some infectious patients in the perioperative period, such as patients with intestinal perforation, causing abdominal infection, it is difficult to prevent infection by using normal saline during surgery. Clinicians often use icodextrin-iodine drugs for external use, mainly polyvinylpyrrolidone-I solution (PVP-I ), Polyethylene Glycol-I (PEG-I), etc. are diluted with physiological saline and then rinsed the abdominal cavity, which is very inconvenient, and it is easy to cause secondary pollution when preparing
Clinically used polyvinylpyrrolidone-I solution (PVP-I), polyethylene glycol-I (PEG-I) low-concentration solutions are extremely unstable, and available iodine is extremely volatile

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] An icodextrin biological material, the icodextrin biological material is composed of icodextrin complexed iodine solution, 1%; osmotic pressure regulating substance: NaCL, 0.6%; or mannitol, 3%; or glycine , 1%; add water for injection to a sufficient amount;

[0024] The icodextrin complexed iodine solution is composed of the following raw materials and their qualities: in every 100Kg of the icodextrin biological material: iodine, 0.25kg; potassium iodide, 0.1kg; potassium iodate, 0.1kg; glycerol , 1-4kg; boric acid, 0.2kg; icodextrin, 5kg and water for injection to make up the balance;

[0025] The preparation method of described icodextrin complexed iodine solution is carried out as follows:

[0026] Step 1) After dissolving potassium iodide and potassium iodate with water for injection, add iodine and mix in a stirring tank to obtain liquid ①;

[0027] Step 2) Mix boric acid, glycerin, and icodextrin, then add water for injection and stir to obtain liquid ②;

[0...

Embodiment 2

[0036] An icodextrin biological material, the icodextrin biological material is composed of icodextrin complexed iodine solution, 5%; osmotic pressure regulating substance: NaCL, 0.7%; or mannitol, 5%; or glycine , 1.5%; add water for injection to a sufficient amount;

[0037] The icodextrin complexed iodine solution is composed of the following raw materials and their quality: in every 100Kg of the icodextrin biological material: iodine, 0.6kg; potassium iodide, 0.3kg; potassium iodate, 0.2kg; glycerol , 3kg; boric acid, 0.2kg; icodextrin, 10kg and water for injection to make up the balance;

[0038] The preparation method of described icodextrin complexed iodine solution is carried out as follows:

[0039] Step 1) After dissolving potassium iodide and potassium iodate with water for injection, add iodine and mix in a stirring tank to obtain liquid ①;

[0040] Step 2) Mix boric acid, glycerin, and icodextrin, then add water for injection and stir to obtain liquid ②;

[004...

Embodiment 3

[0049] An icodextrin biomaterial, the icodextrin biomaterial is composed of icodextrin complexed iodine solution, 8%; osmotic pressure regulating substance: NaCL, 0.9%; or mannitol, 5%; or glycine , 2%; add water for injection to a sufficient amount;

[0050] The icodextrin complexed iodine solution is composed of the following raw materials and their quality: in every 100Kg of the icodextrin biological material: iodine, 1kg; potassium iodide, 0.5kg; potassium iodate, 0.4kg; glycerin, 4kg; boric acid, 0.2kg; icodextrin, 15kg and water for injection to make up the balance;

[0051] The preparation method of described icodextrin complexed iodine solution is carried out as follows:

[0052] Step 1) After dissolving potassium iodide and potassium iodate with water for injection, add iodine and mix in a stirring tank to obtain liquid ①;

[0053] Step 2) Mix boric acid, glycerin, and icodextrin, then add water for injection and stir to obtain liquid ②;

[0054] Step 3) Put the pr...

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PUM

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Abstract

The invention discloses an icodextrin biomaterial with antibacterial and bactericidal effects in a perioperative period. The icodextrin biomaterial is a macromolecular biomaterial which has antibacterial, bactericidal and anti-adhesive effects when applied to surgery in the perioperative period. In the aspect of tumor surgery, the icodextrin biomaterial further has the effect of preventing the implantation metastasis caused by tumor cells which scatter on an inner membrane of a human body cavity during the tumor operation. According to the icodextrin biomaterial, water for injection is used as a carrier, and water-soluble icodextrin and iodine are used as main raw materials to prepare an icodextrin complex iodine biopolymer material. The icodextrin iodine biomaterial is prepared from icodextrin iodine and NaCl for regulating osmotic pressure substance or mannitol or glycine through using the water for injection. The icodextrin biomaterial does not have toxicity, irritation or sensitization for a human body, and has good biodegradability; and in clinic, the icodextrin biomaterial has good effects in antibiosis or sterilization, anti-adhesion and control of cancer cell implantation metastasis.

Description

technical field [0001] The invention relates to a kind of antibacterial or bactericidal, anti-adhesion, and control cancer cell implantation transfer material suitable for perioperative use, in particular to an icodextrin biological material and a preparation method thereof. Background technique [0002] Currently, normal saline is traditionally used as the flushing solution used in clinical practice. Conventional normal saline can neither effectively antibacterial, stop bleeding, prevent tissue adhesion, and promote wound healing, nor can it inhibit the implantation and metastasis caused by the adhesion of scattered tumor cells during surgery. For some infectious patients in the perioperative period, such as patients with intestinal perforation, causing abdominal infection, it is difficult to prevent infection by using normal saline during surgery. Clinicians often use icodextrin-iodine drugs for external use, mainly polyvinylpyrrolidone-I solution (PVP-I ), Polyethylene Gl...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K33/22A61K47/36A61P41/00A61K31/047
CPCA61K31/047A61K33/18A61K33/22A61K47/36A61K2300/00
Inventor 胡军黄海梅
Owner JIANGSU HAIERZI BIOTECH CO LTD
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