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Impedance detecting device and method for in-vivo detection of spongioblastoma boundary and application of device

A malignant glioma and detection device technology, which is applied in the field of electrical impedance detection devices for in vivo exploration of malignant glioma boundaries, can solve the problems of inability to distinguish tumor tissue, expensive MRI equipment, and high photosensitizer content, so as to reduce tumor recurrence. rate, improve the quality of surgical treatment, and preserve the effect of neurological function

Pending Publication Date: 2017-10-13
SHANGHAI CHANGHAI HOSPITAL
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

These methods all have their drawbacks: the tumor border can only be roughly judged by the operating microscope; the photosensitizer detected by the intraoperative photodynamic method has a high content in the glioma solid body and a low content in the glioma border area, and intraoperative ultrasound cannot distinguish Tumor tissue with a diameter of less than 3mm requires the cooperation of doctors with rich experience in ultrasonic image recognition; intraoperative MRI equipment is expensive and imaging time is long, making it difficult to popularize
In the prior art, there is no report about the detection device and detection method of the boundary electrical impedance of malignant glioma that can perform direct contact electrical property measurement of glioma under the state of craniotomy.

Method used

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  • Impedance detecting device and method for in-vivo detection of spongioblastoma boundary and application of device
  • Impedance detecting device and method for in-vivo detection of spongioblastoma boundary and application of device
  • Impedance detecting device and method for in-vivo detection of spongioblastoma boundary and application of device

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Effect test

Embodiment 1 4

[0041] Embodiment 1 Four-probe electrical impedance detection device

[0042] Such as Figure 1-2 as shown, figure 1 is the front view of the four-probe electrical impedance detection device, figure 2 Schematic diagram of the structure of the four-probe electrical impedance detection device. An electrical impedance detection device, comprising an electrode orifice 1 and four electrode probes 2, characterized in that the electrode orifice 1 is cylindrical, the diameter of the electrode orifice 1 is 3mm, and the four electrode probes 2 are separated from the center Points 0.98 mm in circumference are evenly arranged in the electrode orifice plate, and the electrode probe 2 is made of 925 silver wire with a diameter of 3 mm. One end of the electrode probe 2 is welded and fixed to the upper surface of the electrode orifice plate 1, and the other end is connected to the electrode orifice plate. The lower surface of the orifice plate 1 is pierced. The electrode probe includes t...

Embodiment 2

[0043] Embodiment 2 Ring electrical impedance detection device

[0044] Such as Figure 6-7 as shown, Figure 6 is the front view of the ring electrical impedance detection device, Figure 7 It is a schematic diagram of the structure of the ring electrical impedance detection device. An electrical impedance detection device, comprising an electrode hole plate 1, four electrode probes 2, and wires 3 respectively connected to the four electrode probes 2, the four electrode probes 2 are concentrically nested in the electrode hole plate 1 The first electrode 4, the second electrode 5, the third electrode 6 on the surface, and the fourth electrode 7 located at the center of the electrode hole plate 1; the first electrode 4, the second electrode 5, and the third electrode 6 are annular , whose radii are 2.4mm, 1.65mm, and 0.9mm in turn. The width of the first electrode 4 , the second electrode 5 and the third electrode 6 is 0.2 mm. The diameter of the fourth electrode 7 is 0.3 ...

Embodiment 3 4

[0045] Embodiment 3 four-probe impedance measurement experiment

[0046] 1 Impedance measurement experiment preparation

[0047] (1) Establishment of impedance measurement platform

[0048] The used in-body impedance measurement platform mainly includes: four-probe measurement electrodes based on the four-electrode method, an electrode hole plate for fixing the probes, and a clamping mechanism. Such as figure 1 and figure 2 As shown, the electrical impedance detection device includes an electrode hole plate and four electrode probes, wherein the material of the measuring electrode probe is 925 silver (or S925), that is, the silver content is not less than 92.5%. Compared with pure silver, S925 adds 7.5% of other metals, which makes it have better hardness, better shaping, and good oxidation resistance and electrical conductivity. The electrode hole plate used to fix the probe is made of PCB substrate material. On the one hand, for the convenience of processing, because th...

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Abstract

The invention relates to the technical field of biological tissue electrical impedance detection, in particular to an electrical impedance detection device, method and application for in vivo detection of malignant glioma boundaries. The invention designs and manufactures a four-probe type and ring-shaped in-body impedance measurement sensor based on the four-electrode method. Using the impedance analyzer to measure the impedance of glioma and brain tissue, the results show that the impedance amplitude of glioma is smaller than that of brain tissue. Furthermore, the inventors proposed the concept of the slope of the rising slope based on the law of impedance changes, and found that the slope value of the glioma is smaller than that of the brain tissue. For the glioma U87, the average value of γ of the brain tissue is 352.57% larger than it. And this difference is as high as 150.23% for glioma C6, which indicates that the rising slope of glioma U87 / C6 in the impedance map is smaller than that of brain tissue. Therefore, the slope of the rising slope in the impedance spectrum can be used as an index parameter to distinguish glioma from brain tissue.

Description

technical field [0001] The invention relates to the technical field of biological tissue electrical impedance detection, in particular to an electrical impedance detection device, method and application for in vivo detection of malignant glioma boundaries. Background technique [0002] Glioma is the most common intracranial tumor, accounting for about 45% of all intracranial tumors, and its incidence rate is 3-6 per 100,000 people in China. Gliomas originate from the neuroectoderm and are neuroepithelial tumors. They appear as "crab foot" or "tree root" in the brain tissue. Due to their infiltrative growth, they may be accompanied by peritumoral edema and unclear tumor boundaries. The border area of ​​glioma is the area adjacent (infiltrated) between glioma and normal brain tissue, and its pathological changes have its own particularity, often accompanied by peritumoral edema, which is considered to be mainly caused by vasogenic edema. Peripheral edema can separate the tumo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/053A61B5/06
CPCA61B5/0536A61B5/06
Inventor 张煜辉沈林勇章亚男徐守培
Owner SHANGHAI CHANGHAI HOSPITAL
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