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Polyvinyl alcohol hydrogel and preparation method thereof

A technology of polyvinyl alcohol and hydrogel, which is applied in the field of biomaterials and artificial articular cartilage replacement materials, and can solve the problems of difficulty in obtaining polyvinyl alcohol hydrogel, time-consuming removal of pore-forming agents, and easy residue of pore-forming agents. Achieve the effects of avoiding chemical residues and biological toxicity, good biocompatibility, and easy control of process quality

Active Publication Date: 2017-09-22
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that it takes time to remove the pore former, and the unwashed pore former tends to remain in the hydrogel
[0004] The polyvinyl alcohol hydrogel can be made into a pore agent with water without worrying about the residual problem, but the polyvinyl alcohol hydrogel prepared by freezing and thawing only a low-concentration polyvinyl alcohol aqueous solution has a porous structure, and the pore size is small (generally only a few Micron), the water in the high-concentration polyvinyl alcohol aqueous solution tends to generate ultra-cold water during the freezing process, and there is no hole formation in the polyvinyl alcohol hydrogel, so it is difficult to obtain polyvinyl alcohol with high strength and pore structure Hydrogels

Method used

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  • Polyvinyl alcohol hydrogel and preparation method thereof
  • Polyvinyl alcohol hydrogel and preparation method thereof
  • Polyvinyl alcohol hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] In the first step, weigh 15 parts by weight of PVA and add it to 81 parts by weight of deionized water, stir and heat at a constant temperature of 95° C. for 2 hours until the PVA is completely melted to form an aqueous solution of polyvinyl alcohol. In the second step, slowly add 4 parts by weight of agarose, keep heating and stirring at a constant temperature of 95°C for 2 hours until the agarose is completely dissolved and uniformly mixed with the PVA aqueous solution to obtain 15 wt% of PVA and 4 wt% of AG mixed solution. The third step is to pour the prepared mixed solution into the mold, put it into a vacuum drying oven for degassing for 2 hours, and then put it into a low-temperature freezer to freeze and shape. Set the freezing temperature to -20°C and the time to 16 hours, take out the sample to thaw, the thawing temperature to 18°C, and the thawing time to 8 hours. Repeat the freezing and thawing process above to prepare a physically cross-linked PVA hydrogel...

Embodiment 2

[0032] Further, in order to enhance the crystallinity of the PVA molecules in the PVA hydrogel, steps such as liquid freezing can also be added to the above-mentioned preparation method of the polyvinyl alcohol hydrogel.

[0033] (1) In the first step, weigh 15 parts by weight of PVA and add it to 81 parts by weight of deionized water, stir and heat at a constant temperature of 95°C for 2 hours until the PVA is completely melted to form an aqueous solution of polyvinyl alcohol. In the second step, slowly add 4 parts by weight of agarose, keep heating and stirring at a constant temperature of 95°C for 2 hours until the agarose is completely dissolved and uniformly mixed with the PVA aqueous solution to obtain 15 wt% of PVA and 4 wt% of AG mixed solution. The third step is to pour the prepared mixed solution into the mold, put it into a vacuum drying oven for degassing for 2 hours, and then put it into a low-temperature freezer to freeze and form. Set the freezing temperature t...

Embodiment 3

[0039] Further, in order to improve the pore structure in the PVA hydrogel, steps such as desugaring can also be added to the above-mentioned preparation method of the polyvinyl alcohol hydrogel.

[0040] (1) In the first step, weigh 15 parts by weight of PVA and add it to 81 parts by weight of deionized water, stir and heat at a constant temperature of 95°C for 2 hours until the PVA is completely melted to form an aqueous solution of polyvinyl alcohol. In the second step, slowly add 4 parts by weight of agarose, keep heating and stirring at a constant temperature of 95°C for 2 hours until the agarose is completely dissolved and uniformly mixed with the PVA aqueous solution to obtain 15 wt% of PVA and 4 wt% of AG mixed solution. The third step is to pour the prepared mixed solution into the mold, put it into a vacuum drying oven for degassing for 2 hours, and then put it into a low-temperature freezer to freeze and shape. Set the freezing temperature to -20°C and the time to ...

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Abstract

The invention discloses polyvinyl alcohol hydrogel and a preparation method thereof and belongs to the field of biological materials. The polyvinyl alcohol hydrogel is prepared by adopting agarose AG as a pore-forming agent, adopting polyvinyl alcohol as a matrix, freezing and thawing. The polyvinyl alcohol hydrogel is prepared from the following components, counted by 100 parts by mass, 15 to 20 parts of the polyvinyl alcohol, 2 to 6 parts of the agarose and the balance of deionized water. The preparation method comprises the following steps: firstly, completely dissolving the polyvinyl alcohol into the deionized water, then adding the agarose and uniformly mixing; carrying out processes such as defoaming, freezing, thawing and eluting on a mixed solution to obtain the polyvinyl alcohol hydrogel with high strength and a porous structure. The preparation method disclosed by the invention is simple; the obtained hydrogel has the advantages of simple formation and stable structure; mechanical properties and the porous structure of the polyvinyl alcohol hydrogel can meet the requirements of natural articular cartilage materials.

Description

technical field [0001] The invention belongs to the field of biomaterials, in particular to the field of artificial articular cartilage substitute materials, and relates to a polyvinyl alcohol hydrogel with high strength and a porous structure and a preparation method thereof. Background technique [0002] Polyvinyl alcohol (PVA) hydrogel has good biocompatibility, lubricity, mechanical properties similar to human cartilage, high water content (60%-80%), sufficient pore structure (planting chondrocytes), and resistance to Abrasive and fatigue-resistant, it is an ideal substitute material for articular cartilage tissue repair. The hydrogel can contain chondrocytes, growth factors, related genes, drugs, and biological matrices, which are implanted into the lesion to induce in situ cell proliferation, differentiation, and cartilage formation. [0003] In order for the replacement material to better integrate with cartilage tissue, the hydrogel material needs to have pores of a...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/56A61L27/26C08J3/075C08J9/26C08J3/24C08L29/04C08L5/12
Inventor 张伟黄金鑫隋静萍吴承伟
Owner DALIAN UNIV OF TECH
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