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Application of galactooligosaccharide in preparation of medicine for treating intestinal diseases

A technology for galacto-oligosaccharides and intestinal diseases, which can be used in drug combinations, antipyretics, pharmaceutical formulations, etc., can solve problems such as poor treatment effect of inflammatory bowel disease, maintain intestinal microecological balance, and promote beneficial effects. The effect of bacterial proliferation

Inactive Publication Date: 2017-09-15
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present disclosure is to provide a new way to treat inflammatory bowel disease for the problem of poor treatment effect of inflammatory bowel disease

Method used

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  • Application of galactooligosaccharide in preparation of medicine for treating intestinal diseases
  • Application of galactooligosaccharide in preparation of medicine for treating intestinal diseases
  • Application of galactooligosaccharide in preparation of medicine for treating intestinal diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This example is used to illustrate the process of constructing an animal model of inflammatory bowel disease and the process of prevention and treatment of galactooligosaccharides.

[0037] Hepatic Helicobacter H.hepaticus (purchased from ATCC, product number 51448) was aseptically streaked onto sheep blood agar, and incubated in GasPak gas generating bag system (BD Diagnstic Systems) at 36°C for 24-48 hours, and colonies were picked Resuspend in peptone soybean broth for shaking culture, collect the bacterial suspension when the optical density is greater than 1.8 (600nm wavelength), and use it as an infection bacterial liquid for later use.

[0038] Prepare Smad3- / - mice (purchased from Jackson, Cat. No. 003451), divide them into control group and experimental group, and carry out the following treatments:

[0039] Preventive treatment: 1) The mice in the experimental group inhaled 75 μL of galacto-oligosaccharide (purchased from Yuanye, S11138, the same below, 100 mg...

Embodiment 2

[0043] This example is used to illustrate the test results of the animal experiments in Example 1.

[0044] CO was used on D0, D3, D7, and D28 respectively 2Mice were killed by suffocation or bloodletting; heart blood, spleen, colon, cecum, mesenteric lymph nodes, and feces were collected; D0, D7, and D28 days were processed in the experimental group (n=15, 5 / d) and the control group (n=15 / d). =15, 5 / d) mouse colon and cecum tissue for histopathological section research; colon and cecum tissue for the results of histopathological section, according to the scoring standards in the literature for inflammation scoring, the results are as follows figure 1 shown. according to figure 1 It can be seen that the inflammation in the control group became more and more serious, and the inflammation in the experimental group appeared after infection, and the inflammation was significantly reduced at 28 days.

[0045] Treat the mesenteric lymph node tissue and spleen tissue in the experi...

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Abstract

The invention provides application of galactooligosaccharide in preparation of a medicine for alleviating symptoms of inflammatory bowel diseases, application of galactooligosaccharide in preparation of a medicine for treating and / or preventing inflammatory bowel diseases, application of galactooligosaccharide in preparation of nutritional products for regulating inflammatory bowel diseases, and application of galactooligosaccharide in preparation of a medicine for treating intestinal diseases, wherein the intestinal diseases are caused by Smad3 gene function decrease or loss and helicobacter hepaticus infection. By adopting the technical scheme, the invention further provides a novel approach for treating inflammatory bowel diseases. Galactooligosaccharide can be used for promoting reproduction of beneficial bacteria, so that the intestinal microecological balance can be maintained, homing, differentiating and reproducing of natural killer cells can be promoted, and the innate immune system of intestinal tracts can be reconstructed.

Description

technical field [0001] The present disclosure relates to the field of biomedicine, in particular, relates to the use of galacto-oligosaccharides in the preparation of drugs for alleviating symptoms of inflammatory bowel disease, drugs for treating and / or preventing inflammatory bowel disease, nutritional products for regulating inflammatory bowel disease and treating intestinal Use in medicines for diseases of the respiratory tract. Background technique [0002] Inflammatory bowel disease, referred to as IBD, is a special chronic intestinal inflammatory disease, mainly including Crohn's disease (CD) and ulcerative colitis (UC). In the past 30 years, the incidence of IBD in my country has been on the rise. According to domestic literature reports, the number of cases in the past five years is eight times that of the same period in the 1990s. IBD has gradually become a common disease in gastroenterology in my country. [0003] Clinically, patients with inflammatory bowel dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A61K31/7016A61K31/715A61P1/00A61P29/00A61P1/04A61P1/14
CPCA61K31/702A61K31/7016A61K31/715
Inventor 方维佳郑怡蒋微琴
Owner ZHEJIANG UNIV
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