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Anti-tuberculosis bacillus use of wintersweet plants

A technology of anti-tuberculosis and wintersweet, applied in the field of medicine, can solve the problems that there are no research reports on anti-tuberculosis bacteria of willow-leaf wintersweet, Zhejiang wintersweet and mountain wintersweet

Active Publication Date: 2018-11-02
浙江华润三九众益制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Retrieval of pharmacological research information found no research reports on the anti-tuberculosis bacteria of willow-leaved wintersweet, Zhejiang wintersweet and mountain wintersweet

Method used

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  • Anti-tuberculosis bacillus use of wintersweet plants
  • Anti-tuberculosis bacillus use of wintersweet plants
  • Anti-tuberculosis bacillus use of wintersweet plants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-11

[0102] Water extraction: Take the crushed medicinal materials, put them into a round-bottomed flask, and add water to reflux for extraction twice. Add 10-16 times of water for the first time, filter after 1 hour of extraction, and add 8-12 times of water for the second time, extract for 1 hour, and combine the two filtrates. Concentrate on a rotary evaporator or on a water bath, water bath 75℃, rotation speed 80rpm, concentration to a specific gravity of 1.18-1.22, pour it into a stainless steel pan, set a vacuum drying oven at 65℃, vacuum dry and crush.

[0103] Alcohol extraction: Take the crushed medicinal materials, put them into a round-bottomed flask, and add ethanol twice to reflux extraction. Add 10 times ethanol for the first time, extract for 1 hour and then filter, add 8 times ethanol for the second time, extract for 1 hour, and combine the two filtrates. Concentrate on a rotary evaporator at 65°C in a water bath, at a speed of 80 rpm, and when concentrated to a speci...

Embodiment 12

[0108] Example 12 (Supercritical without entrainer)

[0109] Weigh 6.4kgLY and place it in a 24L extraction kettle. Weigh 3.2 kg of 95% ethanol, place it in the storage tank of the auxiliary pump, turn on the auxiliary pump (R=9.1r / min), and add the entrainer within 60 minutes. The pressures of extraction vessel II, separation vessel I, separation vessel II, and separation vessel III are 20.7MPa, 8.5MPa, 5MPa, and 5MPa, respectively, and temperatures are 45℃, 55℃, 40℃, and 40℃ respectively. The rotation speed of the main pump R= 30.5r / min, the flow rate of carbon dioxide is 220-240L / h. After extraction for 135 minutes, after the post-treatment, 1.3 g of product was collected in the separation tank I, and 200.4 g of the product was collected in the separation tank II, numbered LYLJ-2(2-6), and the total yield was 3.15%.

Embodiment 13

[0110] Example 13 (Supercritical without entrainer)

[0111] Weigh 6.5kgLY and place it in a 24L extraction kettle. After the pressure stabilizes, the extraction begins. The pressures of extraction vessel II, separation vessel I, separation vessel II, and separation vessel III are 20MPa, 8MPa, 5MPa, and 5MPa respectively, and the temperatures are 45℃, 55℃, 40℃, and 40℃ respectively. The rotation speed of the main pump is R=30.5r / min, the flow rate of carbon dioxide is 210-230L / h, and the extraction is 103min. After the post-treatment, 101g of reddish-brown oil is collected, the yield is 2.05%, and the code is LYLW(2-2).

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Abstract

The invention discloses a use of chimonanthus plant anti-mycobacterium tuberculosis, and particularly relates to application of a chimonanthus plant and an extractive thereof for preparing pharmaceutical for anti-mycobacterium tuberculosis and diseases caused by the anti-mycobacterium tuberculosis. The chimonanthus plant comprises willow-pattern calyx canthus, Zhejiang calyx canthus and mountain calyx canthus. The extractive comprises a water extractive, an alcohol extractive, a steam distillation extractive and a supercritical extractive.

Description

Technical field [0001] The present invention specifically relates to the application of the Wintersweet plant and its extracts in the preparation of medicines for preventing / treating related diseases caused by Mycobacterium tuberculosis. The Wintersweet plant includes the Willow-leaved Wintersweet, Zhejiang Wintersweet and Wintersweet, belonging to the technical field of medicine. Background technique: [0002] Chimonanthussalicifolius SYHu, Chimonanthuszhejiangensis MCLiu or Chimonanthus nitens Oliv. are folk medicines of the She nationality. Since the Northern Song Dynasty, their dried leaves have been taken as herbal tea for nearly a thousand years. Used to treat and prevent colds. Modern research has made progress again. Among them, the granular preparations prepared from the extracts of Chimonanthus sibiricum have good efficacy in treating / preventing colds and have been sold in the market; Chimonanthus praecox and Zhejiang chinensis have been included in the "Zhejiang Tradit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P31/06
CPCA61K36/185A61K2236/33A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51
Inventor 王子厚张天宇马领弟陈昌红
Owner 浙江华润三九众益制药有限公司
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