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Method for increasing remodeling efficiency of microflora of host intestinal tract

A technology of intestinal microorganisms and hosts, applied in the field of microorganisms, can solve the problems of low microbial colonization efficiency, reduce the application effect of fecal bacteria transplantation, etc., and achieve the effect of efficient change and improvement of transplantation efficiency

Inactive Publication Date: 2017-08-29
CHINA AGRI UNIV
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AI Technical Summary

Problems solved by technology

[0006] However, in the above-mentioned technical solutions, the method of fecal bacteria transplantation is directly used to improve the host intestinal microorganisms. However, due to the robustness of the host intestinal microbial community, the microbial colonization efficiency of fecal bacteria transplantation is very low, which also greatly reduces the quality of fecal bacteria. The application effect of bacterial transplantation

Method used

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  • Method for increasing remodeling efficiency of microflora of host intestinal tract
  • Method for increasing remodeling efficiency of microflora of host intestinal tract
  • Method for increasing remodeling efficiency of microflora of host intestinal tract

Examples

Experimental program
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Embodiment 1

[0032] 1. Experimental animals and feeding conditions

[0033] 8-week-old female mice (ICR) without specific-pathogen-free (SPF) were purchased from Beijing Huafukang Biotechnology Co., Ltd., and were raised in the mouse room of the Feed Industry Center of China Agricultural University at a constant temperature of 20°C. A 12-hour light / dark cycle was used, and mice were fed with a basic diet (18% protein, 4% fat, 5% fiber), and sterile drinking water was ad libitum. Feed and drinking water are changed once a day to ensure fresh feed and drinking water supply. Mice in each treatment group were housed in separate cages.

[0034] 2. Test treatment

[0035] The experimental mice were randomly divided into 3 groups, 10 in each group, which were the control group, the colon cleansing liquid pretreatment group and the combined antibiotic pretreatment group. The control group had free access to sterile clean drinking water. The colon cleansing liquid pretreatment group and the anti...

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Abstract

The invention relates to the technical field of microbes and particularly discloses a method for increasing remodeling efficiency of microflora of a host intestinal tract. The method specifically comprises the steps of pretreating the host intestinal tract by using combined antibiotics, and carrying out intestinal tract caprophyl transplantation on a host. The method disclosed by the invention can be applied to a wide variety of fields such as microbial technologies, zoological medicine and nutriology. According to the method, through pretreating the host intestinal tract by using the combined antibiotics, the transplantation efficiency of caprophyl transplanting can be remarkably increased, the microflora of intestinal tracts of individuals can be efficiently changed, and the aims of disease control can be achieved if necessary.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a method for improving the efficiency of remodeling host intestinal microbial communities. Background technique [0002] A healthy and stable intestinal microbial community has a very close relationship with the health of the host and the homeostasis of the intestinal environment. The structural composition of the host's intestinal symbiotic flora is in a state of interdependence and mutual restriction with the host's health status and the host's living environment. Therefore, when the intestinal flora structure is normal, the host itself has the ability to resist foreign pathogenic bacteria, and the normal flora in the intestinal tract will not pose a hazard to the health of the host. According to current research, intestinal microbial flora imbalance is associated with enteritis, diarrhea, constipation, obesity, depression, diabetes, and autoimmune diseases. The state o...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K31/7036A61K38/14A61K35/744A61P1/00
CPCA61K31/43A61K31/7036A61K35/744A61K38/14A61K2300/00
Inventor 李胜利严慧纪守坤郭春燕刘晶晶蒋涛王雅晶曹志军
Owner CHINA AGRI UNIV
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