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Korean drug compound extract for preventing and treating diabetic nephropathy and preparation method of Korean drug compound extract

A technology of diabetic nephropathy and extract, which is applied in the field of ethnic medicine, can solve the problems of insufficient extraction of active ingredients, low content of active ingredients, and inconvenient transportation and transportation, and achieve the effects of improving kidney function, increasing extraction rate, and saving traditional Chinese medicine resources

Inactive Publication Date: 2017-08-15
延吉朝耀生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the previous application process of this prescription, the simple preparation and use method of decoction and decoction twice a day did not fully extract and enrich the active ingredients of the drug, making the content of active ingredients relatively low and unstable
At the same time, the decoction also has problems such as poor patient compliance, inconvenience in carrying and transportation, and easy deterioration in long-term storage.

Method used

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  • Korean drug compound extract for preventing and treating diabetic nephropathy and preparation method of Korean drug compound extract
  • Korean drug compound extract for preventing and treating diabetic nephropathy and preparation method of Korean drug compound extract
  • Korean drug compound extract for preventing and treating diabetic nephropathy and preparation method of Korean drug compound extract

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0069] Experimental Example 1 Extraction Technology Research

[0070] In this experiment, two extraction methods, water extraction and alcohol extraction, were designed for extraction, and the content of total flavonoids, total polysaccharides and total saponins was used as the investigation index to optimize the extraction process parameters.

[0071] 1.1 Analysis of API ingredients

[0072] Puerarin, a flavonoid compound in Pueraria root in the crude drug, can significantly reduce the blood sugar content, and can prevent and treat diabetes. Scutellaria baicalensis mainly includes flavonoids, among which baicalin can significantly reduce the content of sorbitol in sugar red blood cells, and can inhibit the aldose reductase that induces various chronic complications of diabetes. The main active ingredient of yam is yam polysaccharide, which has a significant hypoglycemic effect. Schisandra oil in Schisandra chinensis can increase SOD, remove free radicals in the body, reduce...

experiment example 2

[0133] Experimental Example 2 Refining Process Research

[0134] 2.1 Preparation of extract

[0135] Raw materials were weighed in proportion, extracted according to the extraction process parameters described in Experimental Example 1, to obtain an extract.

[0136] 2.2 Research on refining process

[0137] The use of "ZTC 1+1" natural adsorption clarifier can remove invalid components such as tannins, proteins, colloids, etc. in Chinese medicine extracts, and has no effect on active components such as flavonoids, alkaloids, polysaccharides, saponins, terpenes, and vitamins. This method can significantly reduce the impurity content of the extract, which provides convenience for the subsequent process, and has the advantages of safety, non-toxicity, no peculiar smell, no residue, economical and practical, so ZTC1+1 natural adsorption clarifier is selected to refine the medicinal extract .

[0138] 2.2.1 Preparation of clarifying agent

[0139] Component A: Weigh 10g of compo...

experiment example 3

[0158] Experimental Example 3 Study on the separation and purification process parameters of effective components

[0159] MAR is a non-ionic polymer adsorbent with a porous network structure and a large specific surface area. The medicinal material extract is passed through the corresponding type of resin column, and the physical adsorption method can be used to selectively adsorb the active components, remove the ineffective components, and enrich the effective components. There are many types of MAR, which can be divided into three types: non-polar, medium-polar and polar according to different monomer molecular structures and polarities, and each type has a different model. D101 type MAR can take into account the separation and purification of flavonoids, saponins, alkaloids and other active ingredients. Therefore, in this experiment, the D101 type was used to separate and purify the refined solution, and the flavonoids, polysaccharides and saponins were used as the measu...

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Abstract

The invention provides a Korean drug compound extract for preventing and treating diabetic nephropathy as well as a preparation method and application of the Korean drug compound extract. The extract mainly comprises the following active ingredients in parts by weight: 100 parts of total polysaccharides, 5-15 parts of general flavones and 3-12 parts of total saponins. The extract comprises the following raw medicinal materials in parts by weight: 2-4 parts of radix puerariae, 2-4 parts of scutellaria baicalensis, 2-4 parts of Chinese yam, 2-4 parts of ligusticum, 1-2 parts of schisandra chinensis, 1-2 parts of platycodon grandiflorum, 1-2 parts of rattletop, 1-2 parts of radix angelicae and 1-2 parts of tuber of dwarf lilyturf. The preparation method comprises the following steps: extracting the raw medicinal materials by taking 20-40% of ethanol as a solvent; refining the extracting solution by adopting a ZTC 1+1 natural clarifying agent, wherein the usage amount of the component B is 5-9%; eluting the refined solution through macroporous resin by using 10-50% of ethanol and 3-5BV; and concentrating and drying the eluent, thereby obtaining the extract. Experiments prove that the extract disclosed by the invention has pharmacological activity and drug action for preventing and treating diabetic nephropathy.

Description

technical field [0001] The invention belongs to the field of ethnic medicines, and in particular relates to a Korean medicine compound extract for diabetic nephropathy, its preparation method and application. Background technique [0002] The present invention is guided by the theory of Chinese Korean ethnic medicine (abbreviation: Korean medicine), learns from the concept of "composition of traditional Chinese medicine", and adopts a unique medicine extraction and separation technology to prepare an extract for preventing and treating diabetic nephropathy. The extract can be used alone or after adding appropriate auxiliary materials to prepare pharmaceutical preparations. The composition of raw materials and flavors of the extract is mainly based on the theory of "four-element medicine" in Korean medicine, referring to the addition and subtraction of traditional compound prescriptions for clinical prevention and treatment of "Taiyin people" and "Xiaxiao". The extraction an...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P13/12A61P3/10
CPCA61K36/232A61K36/236A61K36/346A61K36/488A61K36/539A61K36/57A61K36/71A61K36/79A61K36/8945A61K36/8968A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 郭建鹏林长青南极星朴明贯
Owner 延吉朝耀生物科技有限公司
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