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Application of apatinib serving as medicine for treating echinococcosis

A technology of apatinib and echinococcosis, which is applied in the application field of apatinib as a drug for treating echinococcosis, and can solve problems such as echinococcosis not seen with apatinib

Inactive Publication Date: 2017-08-11
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug is often used to treat metastatic tumors, but there is no report on the use of apatinib for the treatment of echinococcosis

Method used

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  • Application of apatinib serving as medicine for treating echinococcosis
  • Application of apatinib serving as medicine for treating echinococcosis
  • Application of apatinib serving as medicine for treating echinococcosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of Apatinib tablet of the present invention:

[0022] Get 20 grams of Apatinib, add 180 grams of conventional adjuvants for preparing tablets, mix evenly, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0024] Get 20 grams of Apatinib, add conventional adjuvants for preparing capsules such as 180 grams of starch, mix evenly, and make 1000 capsules.

[0025] The following is a comprehensive experiment on the effect of apatinib on alveolar echinococcosis.

[0026] Experimental materials and methods

[0027] Experimental Materials

[0028] Apatinib, with a purity of >98%, (purchased from Sigma, USA), was dissolved in DMSO solution and stored as a stock solution, then filtered through a 0.22 μm filter, and stored at -20 °C. It can be diluted with sterile water to the required concentration during the experiment.

experiment example 1

[0030] Effect of Apatinib on Echinococcus multilocularis

[0031] Purpose and principle: To observe the survival rate of protoscoleum treated with drugs in vitro by trypan blue staining and scanning electron microscope, so as to observe the effect of drugs on Echinococcus multilocularis. Normal living cells have a complete membrane structure, which can repel trypan blue and prevent it from entering the cell; while cells with inactive or incomplete membranes have increased membrane permeability and can be stained blue by trypan blue color. It is generally considered that the integrity of the cell membrane is lost, that is, it is considered dead. The normal protoscole has complete structures such as apical processes, hooks, and horny cortex; after drug action, the apical hooks of the protoscolic are missing, and the horny cortex falls off.

[0032] Method: The cleaned protoscole of Echinococcus multilocularis was added to the 24-well plate, and the control group and drug-dosed...

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Abstract

The invention discloses an application of apatinib serving as a medicine for treating echinococcosis. The apatinib is used in vitro for killing multilocular hydatid cyst protoscoleces, and the apatinib and an optional pharmaceutically acceptable auxiliary material can be prepared into a medicine composition, or the apatinib and other echinococcosis resistant medicines can be prepared into a medicine composition for treating the echinococcosis. The medicine composition can be prepared into an optional pharmaceutical preparation including a tablet, a granule, a capsule, a pill, oral liquid, injection or lipidosome for treating the echinococcosis. Besides, the invention discloses a novel medicine for treating the echinococcosis, and the apatinib serves as an effective component of the novel medicine for treating the echinococcosis. The application of the apatinib for resisting the echinococcosis is widened, experimental research indicate that the apatinib has a remarkable effect of killing the hydatid cyst protoscoleces, growth of hydatid cysts can be effectively inhibited, and obvious cytotoxicity is avoided within effective concentration.

Description

technical field [0001] The invention relates to a new application of apatinib, in particular to the application of apatinib as a medicine for treating echinococcosis. Background technique [0002] Echinococcosis is a serious zoonotic parasitic disease caused by Echinococcus parasitic in humans or host animals. my country is the world's most serious high-incidence area for both cystic and vesicular echinococcosis. Currently, the most widely used anti-echinococcosis drugs are benzimidazoles, including albendazole and mebendazole. Because of insecticides and other reasons, it can only inhibit the growth of parasites but cannot completely and effectively kill parasites, so that a large number of patients must take this drug in large quantities for a long time, but it still has a high postoperative recurrence rate. At the same time, a large number of studies have found that the drug can cause serious adverse drug reactions in multiple systems. Therefore, it is of great signifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/444A61P33/10
CPCA61K31/444
Inventor 高海军景涛包根书辛奇吕薇宋晓霞许光荣
Owner LANZHOU UNIVERSITY
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