Medicinal application of okadaic acid in treating periprosthetical osteolysis

A technology of periprosthetic bone and okadaic acid, which is used in drug combinations, bone diseases, etc.

Pending Publication Date: 2017-08-11
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The relationship between OA and periprosthetic osteolysis after joint replacement has not been studied so far, and the present invention is derived from it

Method used

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  • Medicinal application of okadaic acid in treating periprosthetical osteolysis
  • Medicinal application of okadaic acid in treating periprosthetical osteolysis
  • Medicinal application of okadaic acid in treating periprosthetical osteolysis

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Experimental program
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specific Embodiment approach

[0035] 1. Materials and methods

[0036] 1. Materials

[0037] 1.1 Reagents and experimental equipment

[0038] 1.1.1 Main Drugs and Reagents

[0039]Okadaic acid (OA), purchased from Tocris Bioscience, UK; TRAP staining kit, purchased from Sigma, USA; paraformaldehyde, PBS, DAB chromogen, hematoxylin, eosin, absolute ethanol, distilled water, 10% Chloral hydrate. Titanium particles were purchased from Johnson Matthey chemicals, USA (catalog #00681; Ward Hill, Massachusetts); PP2A antibodies were purchased from Cell Signaling Technology, USA; RANKL and TNF-α antibodies were purchased from Abcam, UK;

[0040] 1.1.2 Main instruments

[0041] Micro-CT (SkyScan 1176, Belgium), paraffin slicer (Leica 2135, Germany), slicer (Leica1120, Germany), paraffin embedding machine (Leica 1150, Germany), Axiovert 40C optical microscope (Zeiss, Germany), A set of surgical instruments, etc.

[0042] 1.2 Experimental animals

[0043] Eighty healthy C57BL / J6 mice, male, weighing 19-22 g, 6...

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Abstract

The invention discloses application of okadaic acid in preparing a drug composition for treating periprosthetical osteolysis. The okadaic acid is of a structure shown as a formula (I). By studying treatment effect of the okadaic acid on periprosthetical osteolysis, a novel path is provided for preventing and treating periprosthetical osteolysis.

Description

technical field [0001] The invention relates to the technical field of new applications of chemical drugs, in particular to the drug use of okadaic acid in treating periprosthetic osteolysis. Background technique [0002] Peri-prosthetic osteolysis (PPO) is an important complication after total joint arthroplasty (TJA), and is often the main cause of failure and revision after arthroplasty. According to reports, about 40,000 patients after joint replacement in the United States need revision surgery every year, and in the next 25 years, the number of hip joint revisions will increase by 1.37 times, and the number of knee joint revisions will increase by 6 times. It also brings great pain and heavy economic loss to patients, and PPO is the main reason for failure and revision after replacement, and its treatment is particularly important. At present, it is believed that the biological reaction caused by long-term wear and tear of the prosthesis, resulting in increased bone r...

Claims

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Application Information

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IPC IPC(8): A61K31/351A61P19/08
CPCA61K31/351
Inventor 耿德春王亮亮史佳伟郭晓斌徐耀增杨惠林
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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