A kind of compound with antitussive effect and its preparation and application

A compound, separation and purification technology, applied in the field of natural medicinal chemistry, can solve the problem of unclear antitussive active ingredients, and achieve the effects of good antitussive activity, simple operation and low cost

Active Publication Date: 2020-04-03
ZHONGSHAN FLASHLIGHT POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the antitussive active ingredients of Lily yunnanensis seeds are still unclear

Method used

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  • A kind of compound with antitussive effect and its preparation and application
  • A kind of compound with antitussive effect and its preparation and application
  • A kind of compound with antitussive effect and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of embodiment 1 CGY-1 and CGY-2

[0035] (1) Preparation of extract

[0036] A, pulverizing 100g of Lily yunnanensis seeds, extracting 3 times at room temperature by a KQ-250DE type ultrasonic machine with 50% ethanol solution by volume percentage, using 1000ml of ethanol each time, each time being 2 hours, merging three extracts, Filter and remove the slag to obtain the Lily yunnanensis seed extract;

[0037] B. Concentrate the extract under reduced pressure to a constant weight with an N-1100V-W type rotary evaporator to obtain a yellow slurry, which is 12 g of the total extract of Lily yunnanensis seeds;

[0038]C. Suspend the total extract of Lily yunnanensis seeds with ultrapure water, extract with 100ml of petroleum ether, then extract with 100ml of ethyl acetate, and obtain 1g of extract after decompression distillation to remove ethyl acetate;

[0039] (2) analyze the extract that step (1) obtains

[0040] The extract obtained in step (...

Embodiment 2

[0048] The preparation method of embodiment 2 CGY-1 and CGY-2

[0049] (1) Preparation of extract

[0050] A, pulverizing 100g of Lily yunnanensis seeds, extracting 2 times at room temperature through a KQ-250DE type ultrasonic machine with 95% ethanol solution by volume percentage, using 1000ml of ethanol at a time, each time being 1 hour, merging three extracts, Filter and remove the slag to obtain the Lily yunnanensis seed extract;

[0051] B. Concentrate the extract under reduced pressure to constant weight with an N-1100V-W rotary evaporator to obtain a yellow slurry, which is 11g of the total extract of Lily yunnanensis seeds;

[0052] C, suspend the total extract of Lily yunnanensis seeds with ultrapure water, extract with 100ml of petroleum ether, then extract with 100ml of ethyl acetate, and obtain 0.9g of extract after removing ethyl acetate under reduced pressure;

[0053] (2) HPLC analysis and HPLC preparation were performed on the extract obtained in step (1). T...

Embodiment 3

[0054] The preparation method of embodiment 3 CGY-1 and CGY-2

[0055] (1) Preparation of extract

[0056] A, pulverizing 100g of Lily yunnanensis seeds, extracting 3 times at room temperature through the KQ-250DE type ultrasonic machine with 75% ethanol solution by volume percentage, each time using 1000ml of ethanol, each time being 1.5 hours, merging three extracts, Filter and remove the slag to obtain the Lily yunnanensis seed extract;

[0057] B. Concentrate the extract under reduced pressure to a constant weight with an N-1100V-W rotary evaporator to obtain a yellow slurry, which is 10.5 g of the total extract of Lily yunnanensis seeds;

[0058] C. Suspend the total extract of Lily yunnanensis seeds with ultrapure water, extract with 100ml of petroleum ether, then extract with 100ml of ethyl acetate, and evaporate the ethyl acetate under reduced pressure to obtain 0.95g of the extract;

[0059] (2) HPLC analysis and HPLC preparation were performed on the extract obtain...

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Abstract

The invention discloses a compound with effect of relieving cough shown as the formula (I) and preparation and application thereof. The invention also provides a preparation method and purposes of the compound. The compound is a compound derived from Cardiocrinum giganteum var. yunnanense through extraction, separation and purification. The Cardiocrinum giganteum var. yunnanense is mainly distributed in the Yunnan-Guizhou Plateau in China, and easy to obtain; the extraction is convenient, the operation is simple, the cost is low, and being proved by pharmacodynamic tests, the compound provided by the invention has good cough-relieving activity, and a new medicine selection is provided clinically. The formula (I) is shown in the description.

Description

technical field [0001] The invention belongs to the field of natural medicinal chemistry, and in particular relates to a compound with antitussive effect and a preparation method thereof, as well as its application in preparing medicines for preventing cough or / and antitussive. Background technique [0002] Cough is a protective reflex action of the human body, which can remove pathological secretions in the respiratory tract and foreign objects entering the respiratory tract from the outside. Increased sensitivity or impaired function will cause harm to the human body. Cough can be divided into acute cough (duration less than 3 weeks), subacute cough (duration 3-8 weeks) and chronic cough (duration more than 8 weeks) according to the duration. Common causes of acute cough are the common cold and acute tracheo-bronchitis; common causes of subacute cough are postinfectious cough, upper airway cough syndrome, and cough variant asthma; common causes of chronic cough are cough v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/32C07D311/40A61K31/352A61P11/14
CPCA61K36/8967C07D311/32C07D311/40
Inventor 吴旖江仁望刘敬朱自荣张娜夏雪
Owner ZHONGSHAN FLASHLIGHT POLYTECHNIC
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